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Nammalwar, B., Bourne, C.R., Wakeham, N., Bourne, P.C., Barrow, E.W., Muddala, N.P, Bunce, R.A., Berlin, K.D., Barrow, W.W. (2015) Modified 2,4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracis. Bioorg. Med. Chem. 23:203-11. PMCID: PMC4278362
Kobayashi, M., Tomohiro, K., Koseki, Y., Bourne, C.R., Barrow, W., Aoki, S. (2014) Identification of novel potential antibiotics against Staphylococcus using structure-based drug screening targeting dihydrofolate reductase. J. of Chemical Information and Modelling, 28:1242-53.
Nammalwar, B., Muddala, N.P., Bourne, C.R., Henry, M., Bourne, P.C., Bunce, R.A., Barrow, E.W., Berlin, K.D., Barrow, W.W. (2014) Synthesis and biological evaluation of 2,4-diaminopyrimidine-based antifolate drugs against Bacillus anthracis. Macromolecules 19:3231. PMCID: PMC4016962
Bourne, C.R., Wakeham, N., Webb, N. Nammalwar, B., Bunce, R.A., Berlin, K.D., Barrow, W.W. (2014) Structure and competitive substrate inhibition of dihydrofolate reductase from Enterococcus faecalis reveals restrictions to co-factor docking. Biochemistry 53:1228-1238. PMCID: PMC3985486
Bourne, C.R. (2014) Utility of the biosynthetic folate pathway for targets in antimicrobial discovery. Antibiotics 3(1): 1-28.
Bourne, C.R., Wakeham, N., Nammalwar, B., Tseitin, V., Bourne, P.C., Barrow, E.W., Ramnarayan, K., Bunce, R.A., Berlin, K.D., Barrow, W.W. (2013) Structure-activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase. Biochimica et Biophysica Acta – Proteins and Proteomics epub Sept. 20, 2012. 1834:46-52. PMCID: PMC3530638
Nammalwar, B., Bunce, R. A., Berlin, K. D., Bourne, C. R., Bourne, P. C., Barrow, E. W., Barrow, W. W. (2013) Comparative Study of the Frech Catalyst with Two Conventional Catalysts in the Heck Synthesis of 2,4-Diaminopyrimidine-based Antibiotics. Organic Preparations and Procedures International. 45(1):66-71. PMC3683996
Nammalwar, B., Bourne, C.R., Bunce, R.A., Wakeham, N., Bourne, P.C., Ramnarayan, K., Mylvaganam, S., Berlin, K.D., Barrow, E.W., Barrow, W.W. (2012) Inhibition of bacterial dihydrofolate reductase by 6-Alkyl-2,4-diaminopyrimidines. ChemMedChem epub Aug. 28. 7:1974-82. PMCID: PMC3570588 *Featured on inside cover figure
Nammalwar, B., Bunce, R.A., Berlin, K.D., Bourne, C.R., Bourne, P.C., Barrow, E.W., Barrow, W.W. (2012) Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis. European Journal of Medicinal Chemistry 54:387-96. PMCID: PMC3408765
Nammalwar, B., Bunce, R. A., Berlin, K. D., Bourne, C. R., Bourne, P. C., Barrow, E. W., Barrow, W. W. (2012) Microwave-assisted Heck synthesis of substituted 2,4-diaminopyrimidine-based antibiotics. Organic Preparations and Procedures International. 44(3):281-87. PMC3691060
Nammalwar, B., Bunce, R.A., Berlin, K.D., Bourne, C.R., Bourne, P.C., Barrow, E.W., Barrow, W.W. (2012) Approaches to iodinated derivatives of vanillin and isovanillin. Organic Preparations and Procedures International. 44(2):146-152. PMC3691065
Bourne, C.R., Barrow, E.W., Bunce, R.A., Bourne, P.C., Berlin, K.D., Barrow, W.W. (2010) Inhibition of antibiotic resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. Antimicrobial Agents and Chemotherapy 54(9): 3825-33. PMCID: PMC2934973
Bourne, C. R., Bunce, R. A., Bourne, P. C., Berlin, K. D., Barrow, E. W., Barrow, W. W. (2009) Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity. Antimicrobial Agents and Chemotherapy 53(7): 3065-73. PMCID: PMC2704665
Barrow, E.W., Clinkenbeard, P.A., Duncan-Decocq, R.A., Perteet, R.F., Hill, K.D., Bourne, P.C., Valderas, M.W., Bourne, C.R., Clarkson, N.L., Clinkenbeard, K.D., Barrow, W.W. (2012) High-throughput screening of a diversity collection using biodefense category A and B Priority pathogens. Journal of Biomolecular Screening 17(7):946-56. PMCID: PMC3700734
Bourne, C.R., Wakeham, N., Bunce, R.A., Nammalwar, B., Berlin, K.D., Barrow, W.W. (2012) Classifying compound mechanism of action for linking whole cell phenotypes to molecular targets. Journal of Molecular Recognition 25:216-23. PMCID: PMC3703735
Bourne, C. R., Katen, S. P., Fulz, M. R., Packianathan, C., Zlotnick, A. (2009) A mutant Hepatitis B virus core protein mimics inhibitors of icosahedral capsid self-assembly. Biochemistry, 48(8): 1736-42. PMCID: PMC2880625
Bourne, C., Lee, S., Venkataiah, B. Lee, A., Korba, B., Finn, M.G., Zlotnick, A. (2008) Small-molecule effectors of Hepatitis B virus capsid assembly give insight into virus lifecycle. Journal of Virology 82(20): 10262-70. PMCID: PMC2566253
Zlotnick, A., Lee, A., Bourne, C. R., Johnson, J. M., Domanico, P. L., Stray, S. J. (2007) In vitro screening for molecules that affect virus capsid assembly and other protein association reactions. Nature Protocols 2(3): 490-98. PMCID: PMC2099249 *Cover figure from this manuscript
Bourne, C. R., Finn, M. G., Zlotnick, A. (2006) Global structural changes in hepatitis B capsids induced by the assembly effector HAP1. Journal of Virology 80(22): 11055-61. PMCID: PMC1642186
Stray, S. J., Bourne, C. R., Punna, S., Lewis, W. G., Finn, M. G., Zlotnick, A. (2005). A heteroaryldihydropyrimidine activates and can misdirect Hepatitis B virus capsid assembly. Proceedings of the National Academies of Science USA, 102(23): 8138-40. PMCID: PMC1149411