ASHBY, MICHAEL T. - University of Oklahoma - Department of Chemistry and Biochemistry

个人简介

BS, 1982, University of Arizona PhD, 1986, University of Arizona Postdoc, 1986-1987, University of Wurzburg, Germany; 1987-1989, University of Chicago

研究领域

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A central scientific objective of our research is to provide an understanding of chemistry that may be diagnostic of related processes in biology. Since the chemistry is often complex and novel, studies of analogous problems in vivo are generally problematic. Therefore, our approach has often been from the bottom up, beginning with simple molecular models. Later, analogous chemistry in proteins is often investigated, thereby setting the stage for biomedical studies. In addition to the scientific objectives of our research, a key educational goal of the work has been to provide scaffolding for the training of graduate students in the study of the mechanisms of biological reactive intermediates using the kinetic method. From the perspective of graduate student research, there are currently two specific aims: SA1: To exploit a newly-developed library of colorimetric thiol derivatives to train kineticists while resolving long-standing mechanistic problems. SA2: To investigate challenging chemical mechanisms that involve inorganic and organic biological reactive sulfur intermediates. For SA2, the chosen problems fall within two general themes: Theme 1 - Redox cascades that begin with the oxidation of (pseudo-)halides (with an emphasis on thiocyanate). Theme 2 - The chemistry of potential biomarkers for oxidative stress by hypohalites. The two themes are related in that potential biomarkers are simply members of the redox cascades that are diagnostic of the parent oxidants and are sufficiently stable to be isolated.