Petros, Rob - University of North Texas

个人简介

2008-present Assistant Professor, Department of Chemistry, University of North Texas, Denton, TX 2006-2008 Postdoctoral Research Fellow, Carolina-Center of Cancer Nanotechnology Excellence, University of North Carolina, Chapel Hill, NC (Prof. Joseph M. DeSimone) 2006 PhD in Chemistry, Columbia University, New York, NY (Prof. Jack R. Norton) 2000/2001 B.Sc./M.Sc. in Chemistry, University of North Texas, Denton, TX (Prof. Ruthanne D. Thomas)

研究领域

Organic

The Petros' research group is geared toward understanding the impact of nano-topography and surface chemistry at the biotic/abiotic interface. The primary goal is translational research that leads to the design of new materials/carriers for targeted drug delivery and new tools to dictate events occurring at the surface of circulating/implantable biomaterials.

近期论文

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Cavazos, R. J.; Morrison, C. S.; Lampe, J. B.; Nguyen, D.; Harris, A. N.; McFarlin, B. K.; Petros, R. A.* “In Vitro Evaluation of Macropinocytic Uptake and Toxicity of Cobalt Crosslinked Albumin Nanoparticles in Gastric Carcinoma Cells,” submitted. Marpu, S.; Upadhyay, P.; Wang, O.; Oswald, I.; Aravapally, R.; Nguyen, D.; Petros, R. A.*; Hu, Z.; Omary, M. A.* “Self-Assembly of Linear Polymers into Phosphorescent Nanoparticles: Optimization toward Non-Cytotoxic Bioimaging and Photonic Devices,” submitted. Faure, L.; Cavazos, R. J.; Khan, B. R.; Petros, R. A.*; Koulen, P.; Blancaflor, E. B.; Chapman, K. D.* “Effects of Synthetic Alkamides on Arabidopsis Fatty Acid Amide Hydrolase Activity and Plant Growth,” Phytochemistry, in press. Kolodziejczyk, T. K.; Morrison, C. S.; Petros, R. A.* “Rapid, Quantitative, Solvent-Free Synthesis of Medium-Ring Diaza Heterocycles from Diketene-Acetone Adduct and Diamines,” Tetrahedron Letters, 2014, 55, 6547-6549. Petros, R. A. “Synthesis and use of prodrug complexes of cobalt in polymer therapeutics,” Provisional Patent Application 61982667, filed April 22, 2014. Nguyen, D.; Cavazos, R. J.; Harris, A. N.; Petros, R. A.* “Werner Complexes Viewed Anew: Utilizing Cobalt Coordination Chemistry for “Traceless” Stimuli-Responsive Bioconjugation Involving Therapeutic Nanoparticles, Protein PEGylation, and Drug-(Bio)Polymer Conjugates,” Comment Inorg. Chem., 2014, 34, 59-77. Shah, J.*; Chaturvedi, R.; Chowdhury, Z.; Venables, B.; Petros, R. A. “Signaling by small metabolites in systemic acquired resistance,” Plant J., 2014, 79, 645-658. Petros, R. A.*; Shah, J. “Evaluation of the efficiency of Pd/H2-catalyzed benzylic H/D exchange of dehydroabietinal with D2O and synthesis of a tritium-labeled analogue,” J. Labelled Compd. Rad., 2014, 57, 53-56. DOI: 10.1002/jlcr.3117 Chaturvedi, R.; Venables, B.; Petros, R. A.; Nalam, V.; Li, M.; Wang, X.; Takemoto, L. J.; Shah, J. "Dehydroabietinal signaling in systemic acquired resistance," Plant J. 2012, 71, 161-172. DOI: 10.1111/j.1365-313X.2012.04981.x Bussy, C.; Alexiou, C.; Petros, R. A.; Nyström, A.; Kostarelos, K. “Therapeutic applications of Engineered Nanomaterials.” In Adverse Effects of Engineered Nanomaterials: a Disease-Oriented Approach, Fadeel, B.; Pietroiusti, A.; Shvedova, A., Eds. Elsevier, 2012. ISBN: 978-0-12-386940-1 Petros, R. A. “Synthesis and Use of Metal Ion-Containing Polymeric Particles” U.S. Patent Appl. 61/370,682, 2012. (link) Harris, A. N.; Hinojosa, B. R.; Chavious, M. D.; Petros, R. A. "Beyond Platinum: Synthesis, Characterization, and In Vitro Toxicity of Cu(II)-Releasing Polymer Nanoparticles for Potential Use as a Drug Delivery Vector," Nanoscale Res. Lett. 2011, 6, 445. DOI:10.1186/1556-276X-6-445 (designated as ‘highly accessed’ by BioMed Central, an open access publisher of 220 journals) Camara, J. M.; Petros, R. A.; Norton, J. R. “Zirconium-Catalyzed Carboalumination of alpha-Olefins and Chain Growth of Aluminum Alkyls: Kinetics and Mechanism” J. Am. Chem. Soc., 2011, 133, 5263-5273. DOI: 10.1021/ja104032w Galloway, A. L.; Murphy, A.; Rolland, J. P.; Herlihy, K. P.; Petros, R. A.; DeSimone, J. M. “Micromolding for the Fabrication of Biological Microarrays.” In Biological Microarrays, Suh, K.-Y.; Zourob, M.; Khademhosseini, A., Eds. Humana Press: 2011, 671, 249-260. DOI: 10.1007/978-1-59745-551-0_15 Wang, J.; Tian, S.; Petros, R. A.; Napier, M. E.; DeSimone, J. M. “The Complex Role of Multivalency in Nanoparticles Targeting the Transferrin Receptor for Cancer Therapies” J. Am. Chem. Soc., 2010, 132, 11306-11313. DOI: 10.1021/ja1043177 Petros, R. A.; DeSimone, J. M. “Strategies in the design of nanoparticles for therapeutic applications” Nature Reviews – Drug Discovery, 2010, 9, 615-627. DOI: 10.1038/nrd2591 Brown, J. M.; Hoffmann, W. D.; Alvey, C. M.; Wood, A. R.; Verbeck, G. F.; Petros, R. A., “OBOC Peptide Library Sequencing via High-Pressure Ammonia Cleavage Coupled with Nanomanipulation/Nanoelectrospray Mass Spectrometry,” Anal. Biochem., 2010, 398, 7-14. DOI:10.1016/j.ab.2009.10.044 DeSimone, J. M.; Petros, R. A., “Challenges to Developing New Nanomarterials.” In Cancer Nanotechnolgy Plan (CaNano Plan), Grodzinski, P.; Farrell, D.; Hinkal, G.; Hook, S. S.; Panaro, N.; Ptak, K., Eds. Office of Cancer Nanotechnology Research, Center for Strategic Scientific Initiatives, NCI/NIH: 2010, 5-8. (link) Petros, R. A. “Direct utilization of plasma proteins for the in vivo assembly of protein-drug/imaging agent conjugates, nanocarriers and coatings for biomaterials,” Prov. U.S. Patent Appl. 61/141,536, 2010. (link) DeSimone, J. M.; Tian, S.; Wang, J.; Napier, M.; Petros, R. A. “Transferrin Receptor-Targeted Particles and Uses Thereof,” Prov. U.S. Patent Appl. 61/287,090, 2009.