庄红芹 - 南京大学 - 生命科学学院

个人简介

南京大学生命科学院副教授，博士生导师，主要从事死亡受体通路的“多维”研究，一方面阐述其在肿瘤治疗中的应用，发现多个调控凋亡敏感性的分子靶点、多个具有特色的调控肿瘤细胞凋亡敏感性的中药小分子化合物以及药物联合治疗方法，为肿瘤的治疗提供了新的药物靶点及治疗策略；另一方面致力于死亡受体通路中经典凋亡蛋白的非凋亡功能研究，发现凋亡接头蛋白FADD在糖脂代谢中的调控作用及其对“肥胖症”发生、发展的干预作用。共发表SCI收录的论文23篇，包括EMBO Molecular Medicine，Molecular Cancer，Molecular & Cellular Proteomics 等杂志，其中第一作者及共同通讯作者17篇。主持科研项目11项，包括3项国家自然科学基金项目，1项973计划和1项863计划项目子课题，1项国防科技创新特区项目以及2项江苏省基金项目。获得中国发明专利和美国发明专利授权各一项。作为主要完成人获得2017年江苏省科学技术一等奖和第四届“江苏医药科技进步奖”二等奖。教学上指导本科生获得国际遗传工程机器竞赛亚洲区银奖和江苏省优秀毕业设计团队奖；担任中学生英才计划导师，指导学生参加2016年“英才论坛”获得优秀证书。

研究领域

1、经典凋亡蛋白FADD的非凋亡功能研究；2、脂代谢、能量代谢与肥胖干预 3、肿瘤基因治疗

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. FADD is a key regulator of lipid metabolism. Zhuang H , Wang X, Zha D, Gan Z, Cai F, Du P, Yang Y, Yang B, Zhang X, Yao C, Zhou Y, Jiang C, Guan S, Zhang X, Zhang J, Jiang W, Hu Q, Hua ZC. EMBO Mol Med. 2016 Aug 1;8(8):895-918. (第一作者，IF=10.293) 2. Herbal compound triptolide synergistically enhanced antitumor activity of amino-terminal fragment of urokinase. Lin Y, Peng N, Li J, Zhuang H* , Hua ZC*. Mol Cancer. 2013 Jun 8;12:54. (通讯作者，IF=7.776) 3. Role of Fas-associated death domain-containing protein (FADD) phosphorylation in regulating glucose homeostasis: from proteomic discovery to physiological validation. Yao C#, Zhuang H# , Du P, Cheng W, Yang B, Guan S, Hu Y, Zhu D, Christine M, Shi L, Hua ZC. Mol Cell Proteomics. 2013 Oct;12(10):2689-700. (共同一作，IF=6.759) 4. Weiwei Jiang, Guanghui Jin, Fangfang Cai, Xiao Chen, Nini Cao, Xiangyu Zhang, Jia Liu, Fei Chen, Feng Wang, Wei Dong, Hongqin Zhuang* , Zi-Chun Hua*. Extracellular signal-regulated kinase 5 increases radioresistance of lung cancer cells by enhancing the DNA damage response. Experimental & Molecular Medicine. Accepted. (通讯作者，IF=5.584) 5. Curcumol potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer. Cai F, Chen M, Zha D, Zhang P, Zhang X, Cao N, Wang J, He Y, Fan X, Zhang W, Fu Z, Lai Y, Hua ZC*, Zhuang H* . Oncotarget. 2017 Dec 14;8(70):115526-115545. （通讯作者，IF=5.312） 6. Astragalin-induced cell death is caspase-dependent and enhances the susceptibility of lung cancer cells to tumor necrosis factor by inhibiting the NF-кB pathway. Chen M, Cai F, Zha D, Wang X, Zhang W, He Y, Huang Q, Zhuang H* , Hua ZC*. Oncotarget. 2017 Apr 18;8(16):26941-26958 (通讯作者，IF=5.312). 7. Suppression of HSP70 expression sensitizes NSCLC cell lines to TRAIL-induced apoptosis by upregulating DR4 and DR5 and downregulating c-FLIP-L expressions. Zhuang H , Jiang W, Zhang X, Qiu F, Gan Z, Cheng W, Zhang J, Guan S, Tang B, Huang Q, Wu X, Huang X, Jiang W, Hu Q, Lu M, Hua ZC. J Mol Med (Berl). 2013 Feb;91(2):219-35. (第一作者，IF=4.963) 8. Proteomic screening of anaerobically regulated promoters from Salmonella and its antitumor applications. Chen J#, Wei D#, Zhuang H# , Qiao Y, Tang B, Zhang X, Wei J, Fang S, Chen G, Du P, Huang X, Jiang W, Hu Q, Hua ZC. Mol Cell Proteomics. 2011 Jun;10(6):M111.009399. (共同一作，IF=6.759) 9. Apigenin potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependent manner. Chen M, Wang X, Zha D, Cai F, Zhang W, He Y, Huang Q, Zhuang H* , Hua ZC*. Sci Rep. 2016 Oct 18;6:35468. (通讯作者，IF=4.122) 10. FADD phosphorylation impaired islet morphology and function. Yao C#, Zhuang H #, Cheng W, Lin Y, Du P, Yang B, Huang X, Chen S, Hu Q, Hua ZC. J Cell Physiol. 2015 Jul;230(7):1448-56. (共同一作，IF=4.08) 11. Heat shock proteins HSP70 and MRJ cooperatively regulate cell adhesion and migration through urokinase receptor. Lin Y#, Peng N#, Zhuang H #, Zhang D, Wang Y, Hua ZC. BMC Cancer. 2014 Aug 30;14:639. (共同一作，IF=3.288) 12. Expression, purification and biological characterization of human vasostatin120-180 in Pichia pastoris. Lin Y, Yang X, Lu M, Zhuang H *, Hua ZC*. Protein Expr Purif. 2013 Dec;92(2):141-7. (通讯作者，IF=1.351) 13. Herbal compound triptolide synergistically enhanced antitumor activity of vasostatin120-180. Lin Y, Yang X, Lu M, Zheng W, Zhang J, Zhuang H *, Hua ZC*. Anticancer Drugs. 2013 Oct;24(9):945-57. (通讯作者，IF=2.32) 14. Expression, purification, and biological characterization of the amino-terminal fragment of urokinase in Pichia pastoris. Li J, Lin Y, Zhuang H* , Hua ZC*. J Microbiol Biotechnol. 2013 Sep 28;23(9):1197-205. (通讯作者，IF=1.75) 15. Comparative proteomics analysis reveals roles for FADD in the regulation of energy metabolism and proteolysis pathway in mouse embryonic fibroblast. Zhuang H , Gan Z, Jiang W, Zhang X, Hua ZC. Proteomics. 2013 Aug;13(16):2398-413. (第一作者，IF=4.041) 16. Functional specific roles of FADD: comparative proteomic analyses from knockout cell lines. Zhuang H , Gan Z, Jiang W, Zhang X, Hua ZC. Mol Biosyst. 2013 Aug;9(8):2063-78. (第一作者，IF=2.823) 17. Down-regulation of HSP27 sensitizes TRAIL-resistant tumor cell to TRAIL-induced apoptosis. Zhuang H , Jiang W, Cheng W, Qian K, Dong W, Cao L, Huang Q, Li S, Dou F, Chiu JF, Fang XX, Lu M, Hua ZC. Lung Cancer. 2010 Apr;68(1):27-38. (第一作者，IF=4.294) 18. Cheng W, Zhang R, Yao C, He L, Jia K, Yang B, Du P, Zhuang H, Chen J, Liu Z, Ding X, Hua Z (*). A Critical Role of FADD (Fas-Associated Protein with Death Domain) Phosphorylation in Intracellular Reactive Oxygen Species (ROS) Homeostasis and Aging. Antioxid Redox Signal. 2014 Jul 1;21(1):33-45. (IF5年平均= 8.499) 19. Cheng W, Wang L, Zhang R, Du P, Yang B, Zhuang H, Tang B, Yao C, Yu M, Wang Y, Zhang J, Yin W, Li J, Zheng W, Lu M, Hua Z (*). Regulation of protein kinase C inactivation by Fas-associated protein with death domain. J Biol Chem. 2012 Jul 27; 287(31):26126-35. (IF5年平均= 4.863) 20. Qiu F, Hu M, Tang B, Liu X, Zhuang H, Yang J, Hua ZC (*). Annexin V-TRAIL fusion protein is a more sensitive and potent apoptotic inducer for cancer therapy. Sci Rep. 2013 Dec 20;3:3565. (IF5年平均= 5.078)