徐强 - 南京大学 - 生命科学学院

研究领域

主要从事免疫药理学、分子药理学等领域的研究。以药理学为桥梁，研究触角向基础医学、临床医学和化学生物学自然交叉延伸，实现从新的角度阐释疾病的发生发展机理、寻找新的药物作用靶点或生物分子事件、进而研制新型药物的目标。主要研究方向包括：免疫应答与炎症的分子基础及其选择性调控；炎-癌转化的分子机制研究；基于小分子化合物作用特点的化学生物学研究等。

近期论文

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1. Wenjie Guo,Yang Sun,Wen Liu,Xingxin Wu,Lele Guo,Peifen Cai, Xuefeng Wu,Xudong Wu,Yan Shen,Yongqian Shu,Yanhong Gu,Qiang Xu*. Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer. Autophagy 2014; 10(6):972–985. 2.Li Zhang, Yang Sun, Mingjian Fei, Cheng Tan, Jing Wu, Jie Zheng, Jiqing Tang, Wei Sun, Zhaoliang Lv, Jiandong Bao, Qiang Xu* and Huixin Yu. Disruption of chaperone-mediated autophagy dependent degradation of MEF2A by oxidative stress-induced lysosome destabilization. Autophagy 2014; 10(6):1015-35. 3.Li W, Ouyang Z, Zhang Q, Wang L, Shen Y, Wu X, Gu Y, Shu Y, Yu B, Wu X, Sun Y, Xu Q*. SBF-1 exerts strong anticervical cancer effect through inducing endoplasmic reticulum stress-associated cell death via targeting sarco/endoplasmic reticulum Ca(2+)-ATPase 2. Cell Death Dis 2014; 5: e1581. 4.Wang X, Zhang A, Gao J, Chen W, Wang S, Wu X, Shen Y, Ke Y, Hua Z, Tan R, Sun Y, Xu Q*. Trichomide A, a natural cyclodepsipeptide, exerts immunosuppressive activity against activated T lymphocytes by upregulating SHP2 activation to overcome contact dermatitis. J Invest Dermatol 2014; 134(11): 2737-46. 5‍‍.‍‍‍‍‍‍‍‍Luo Q, Sun Y, Gong FY, Liu W, Zheng W, Shen Y, Hua ZC, Feng GS, Xu Q*. ‍‍Blocking initial infiltration of pioneer CD8+ T cells into the CNS via inhibition of SHP-2 ameliorates experimental autoimmune encephalomyelitis in mice. ‍‍‍‍‍‍‍‍Br J Pharmacol 2014; 171: 1706-21. 6. WJ Guo, YM Zhang, L Zhang, B Huang, FF Tao, W Chen, ZJ Guo*, Q Xu*, Y Sun*. Novel monofunctional platinum (II) complex Mono-Pt induces apoptosis-independent autophagic cell death in human ovarian carcinoma cells distinct from cisplatin. Autophagy 2013; 9: 996-1008. 7. Q Luo, Y Sun*, W Liu, C Qian, B Jin, F Tao, Y Gu, X Wu, Y Shen, Q Xu*. A novel disease-modifying antirheumatic drug, iguratimod, ameliorates murine arthritis by blocking IL-17 signaling, distinct from methotrexate and leflunomide.J Immunol2013; 191: 4969-4978. 8. T Zhang, W Guo, Y Yang, W Liu, L Guo, Y Gu, Y Shu, L Wang, X Wu, Z Hua, Y Ke, Y Sun, Y Shen, Q Xu*. Loss of SHP-2 activity in CD4+ T cells promotes melanoma progression and metastasis. Sci Rep 2013; 3: 2845. 9. X Wu, W Guo, L Wu, Y Gu, L Gu, S Xu, X Wu, Y Shen, Y Ke, R Tan, Y Sun, Q Xu*. Selective sequestration of STAT1 in the cytoplasm via phosphorylated SHP-2 ameliorates murine experimental colitis. J Immunol 2012, 189: 3497-3507. 10. L Wang, L Wang, Y Gu, Y Shu, Y Shen,Q Xu*. Integrin a6high cell population functions as an initiator in tumorigenesis and relapse of human liposarcoma. Mol Cancer Ther 2011; 10: 2276-2286. 11. L Wang, L Wang, R Song, Y Shen, Y Sun, Y Gu, Y Shu, Q Xu*. Targeting sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2 by curcumin induces ER stress-associated apoptosis for treating human liposarcoma. Mol Cancer Ther 2011; 10: 461-471. 12. W Zhao, Y Gu, R Song, B Qu, Q Xu*. Sorafenib inhibits activation of human peripheral blood T cells by targeting LCK phosphorylation. Leukemia 2008; 22(6): 1226-33. 13. J Guo, Q Xu*,T Chen. Identification of a new metabolite of astilbin, 3'-O-methylastilbin, and its immunosuppressive activity against contact dermatitis. Clin Chem 2007; 53: 465-471. 14. M Fei, X Wu, Q Xu*. Astilbin inhibits contact hypersensitivity via negative cytokine regulation distinct from cyclosporin A. J Allergy Clin Immunol 2005; 116(6): 1350-1356. 15. X Wu,H Zeng, X Zhang,Y Zhao,H Sha, X Ge, M Zhang, X Gao, Q Xu*. Phosphatase of Regenerating Liver-3 Promotes Motility and Metastasis of Mouse Melanoma Cells. Am J Pathol 2004; 164(6): 2039-2054.