吴兴新 - 南京大学 - 生命科学学院

个人简介

2010-2013年在耶鲁大学医学院从事免疫病理领域的博士后研究工作，2017获得国家优秀青年基金，2018年经绿色通道获聘南京大学教授。致力于发现免疫相关疾病的新治疗策略的研究，研究方向为选择性免疫抑制；重构细胞稳态；化学生物学。主持国家级自然科学基金4项，研究在Nat Commun，PNAS，J Invest Dermatol，J Immunol，Biochem Pharmacol等杂志上发表，被包括Lancet, Nature Medicine, Immunity等顶级杂志他引。

研究领域

药理学，免疫学，化学生物学 1、选择性免疫抑制研究(IMMUNOSUPPRESSION) 炎症性肠病、银屑病及风湿性关节炎等自身免疫性疾病的共性及特性研究；选择性免疫抑制策略及相关药物研发。 2、基于稳态重构的药理学研究(HOMEOSTASIS) 对肝损伤-肝纤维化-肝硬化-肝癌进程的临界点研究；基于恢复细胞稳态治疗肝纤维化的策略及药物研发。 3、膜受体命运的化学生物学研究(RECEPTOR FATE) 小分子化合物调控受体命运的作用机制研究；细胞膜受体动态集群的分子机制研究。

近期论文

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1.Tan, Y. Xingxin Wu*, Jin Sun, Wenjie Guo, Fangyuan Gong, Fenli Shao, Tao Tan, Yi Cao, Bingfeng Zheng, Yanhong Gu, Yang Sun, and Qiang Xu*. A fumigaclavine C isostere alleviates Th1-mediated experimental colitis via competing with IFN-gamma for binding to IFN-gamma receptor 1. Biochemical pharmacology 2017 123, 63-72.（* Co-Corresponding Author） 2.Wu, X. Xudong Wu, Yuxiang Ma, Fenli Shao, Yang Tan, Tao Tan, Liyun Gu, Yang Zhou, Beicheng Sun, Yang Sun, Xuefeng Wu, and Qiang Xu. CUG-binding protein 1 regulates HSC activation and liver fibrogenesis. Nature Communications 2016 7, 13498. 3.Wang, X.1 Chunhui Hu1, Xingxin Wu1, Shiyu Wang, Aihua Zhang, Wei Chen, Yan Shen, Renxiang Tan, Xuefeng Wu, Yang Sun, and Qiang Xu. Roseotoxin B Improves Allergic Contact Dermatitis through a Unique Anti-Inflammatory Mechanism Involving Excessive Activation of Autophagy in Activated T Lymphocytes. Journal of investigative dermatology 2016 136 (8), 1636-46.（1 Co-First Author） 4.Shao, F. Tao Tan, Yang Tan, Yang Sun, Xingxin Wu*, and Qiang Xu*. Andrographolide alleviates imiquimod-induced psoriasis in mice via inducing autophagic proteolysis of MyD88. Biochemical pharmacology 2016 115, 94-103.（* Co-Corresponding Author） 5.Wu, X. Amit Lahiri, Ritu Sarin, and Clara Abraham. T cell-extrinsic CD18 attenuates antigen-dependent CD4+ T cell activation in vivo. Journal of immunology 2015 194 (9), 4122-9. 6.Wu, X. Fenli Shao, Yuanyuan Yang, Liyun Gu, Wei Zheng, Xuefeng Wu, Yanhong Gu, Yongqian Shu, Yang Sun, and Qiang Xu. Epigallocatechin-3-gallate sensitizes IFN-gamma-stimulated CD4+ T cells to apoptosis via alternative activation of STAT1. International immunopharmacology 2014 23 (2), 434-41. 7.Wu, X. Amit Lahiri, G. Kenneth Haines, 3rd, Richard A. Flavell, and Clara Abraham. NOD2 regulates CXCR3-dependent CD8+ T cell accumulation in intestinal tissues with acute injury. Journal of immunology 2014 192 (7), 3409-18. 8.Wu, X. Yang Sun, Wenjie Guo, Yanhong Gu, Xuefeng Wu, Renxiang Tan, and Qiang Xu. Rebuilding the balance of STAT1 and STAT3 signalings by fusaruside, a cerebroside compound, for the treatment of T-cell-mediated fulminant hepatitis in mice. Biochemical pharmacology 2012 84 (9), 1164-73. 9.Wu, X. Wenjie Guo, Limei Wu, Yanhong Gu, Liyun Gu, Suhai Xu, Xuefeng Wu, Yan Shen, Yuehai Ke, Renxiang Tan, Yang Sun, and Qiang Xu. Selective sequestration of STAT1 in the cytoplasm via phosphorylated SHP-2 ameliorates murine experimental colitis. Journal of immunology 2012 189 (7), 3497-507. 10.Sarin R, Wu X, Abraham C. Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses. Proc Natl Acad Sci U S A 2011;108:9560-5.