沈萍萍 - 南京大学 - 生命科学学院

个人简介

生命科学学院教授、博士生导师医药生物技术国家重点实验室——鼓楼医院研究中心，课题组长南京大学模式动物研究中心，课题组长入选教育部2006年度新世纪优秀人才计划作为课题负责人主持自然科学基金委面上及重大研究计划、江苏省自然科学基金重点项目等多项研究课题；同时为自然科学基金委创新研究团队及国家重点研发计划主要学术骨干

研究领域

主要进行炎症相关免疫微环境调控的研究，以巨噬细胞功能重编程为切入点，研究组织微环境的炎性调控及相关信号转导机制，同时研发细胞免疫治疗相关新技术

近期论文

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Niu Z.Y., Shi Q., Zhang W.L., Chen B., Wang Q.S., Zhao X.Y., Chen J.J., Shu Y.X., Cheng N., Feng X.J., Ji J.G., Shen P.P.*, Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs. Nature Communications, 2017, 8(1): 766, Su Y.Y., Hu M., Fan C.H., He Y., Li Q.N., Li W.X., Wang L.H., Shen P.P.*, Huang Q.*, The cytotoxicity of CdTe quantum dots and the relative contributions from released cadmium ions and nanoparticle properties. Biomaterials , 2010, 31: p. 4829-4834. Su Y.Y., He Y., Lu H.T., Sai L., Li Q.N., Li W.X., Wang L.H., Shen P.P.*, Huang Q., Fan C.H. *,The cytotoxicity of cadmium based, aqueous phase Synthesized, quantum dots and its modulation by surface coatin. Biomaterials, 2009, 30: p. 19-25. Liu P., Li C., Zhang R.X., Tang Q., Wei J., Lu Y., Shen P.P. *, An ultrasensitive electrochemical immunosensor for procalcitonin detection based on the gold nanoparticles-enhanced tyramide signal amplification strategy. Biosensors and Bioelectronics, 2019,126: p.543-550. Lin X.Z., Zheng W., Liu J., Zhang Y., Qin H.H., Wu H.C., Xue B., Lu Y., Shen P.P. *, Oxidative stress in malignant melanoma enhances TNF-α secretion of tumor-associated macrophages that promote cancer cell invasion. Antioxidants & Redox Signaling, 2013, 19(12): p.1337-1355. Lu Y., Zhang Y., Li L., Feng X.J., Ding S., Zheng W., Li J.X., Shen P.P.*, TAB1: a target of triptolide in macrophages. Chemistry & Biology, 2014, 21(2): p.246-256. Xu H.W., Wei Y.N., Zhang Y., Xu Y.C., Li F., Liu J., Zhang W., Han X.D., Tan R.X., Shen P.P.*, Oestrogen attenuates tumor malignancy in hepatocellular carcinoma progression. Journal of Pathology , 2012, 228: p.216–229 . Feng X.J., Weng D., Zhou F.F., Young D. Owen, Qin H.H., Zhao J.F., Yu W., Huang Y.H., Chen J.J., Fu H.J., Yang N.F., Chen D.H., Li J.X., Tan R.X., Shen P.P.* , Activation of PPARγ by a natural flavonoid modulator, apigenin ameliorates obesity-related inflammation via regulation of macrophage polarization. EbioMedicine, 2016, 9: p.61–76. Dai H.R. , Zhang W.Y., Li X.L., Han Q.W., Guo Y.L., Zhang Y.J., Wang Y., Wang C.M., Shi F.X., Zhang Y., Chen M.X., Feng K.C., Wang Q.S., Zhu H.L., Fu X.B., Li S.X., Han W.D.*, Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia. Oncoimmunology, 2015, 4(11):e1027469. Sun T.Z., Li X.D., Shen P.P.*, Modeling amplified p53 responses under DNA-PK inhibition in DNA damage response. Oncotarget, 2017, 8(10): p.17105-17114. Shu Y.X., Lu Y., Pang X.J., Zheng W., Huang Y.H., Li J.H., Ji J.G., Zhang C., Shen P.P.*, Phosphorylation of PPARγ at Ser84 promotes glycolysis and cell proliferation in hepatocellular carcinoma by targeting PFKFB4. Oncotarget, 2016, 7(47): p.76984-76994. Feng X.J., Yu W., Li X.D., Zhou F.F., Zhang W.L., Shen Q., Li J.X., Zhang C., Shen P.P.*, Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. Biochemical Pharmacology, 2017, 136: p. 136-149. Ding S., Qian Steven Y., Zhang Y., Wu W.L., Lu G.S., Lu Y., Feng X.J., Li L., Shen P.P.* Establishment of immunoassay for detecting HPV16 E6 and E7 RNA. Scientific Reports, 2015, 5: p. 13686. Feng X.J., Sun T.Z., Bei Y.C., Zheng W., Lu Y., Shen P.P.*, S-nitrosylation of ERK inhibits ERK phosphorylation and induces apoptosis. Scientific Reports, 2013, 3: p. 1814. Niu Z.Y., Tang J.J., Zhang W.L., Chen Y.J., Huang Y.H., Chen B., Li J.H., Shen P.P.*, Caspase-1 promotes monocyte/macrophage differentiation by repressing PPARγ. FEBS Journal, 2017, 284: p. 568–585. Pang X.J., Wei Y.N., Zhang Y., Zhang M.Y., Lu Y.*, Shen P.P.*, PPARγ activation inhibits hepatocellular carcinoma cell invasion by up-regulating PAI-1. Cancer Science, 2013, 104(6): p. 672-680. Yao Y.F., Shi Q., Chen B., Wang Q.S., Li X.D., Li L., Huang Y.H., Ji J.G., Shen P.P.*, Identification of Caspase-6 as a New Regulator of Alternatively Activated Macrophages. Journal of Biological Chemistry, 2016, 291(33): p. 17450-17466. Yang W.W., Lu Y., Xu Y.C., Xu L.Z., Zheng W., Wu Y.Y., Li L., Shen P.P.*, Estrogen represses Hepatocellular Carcinoma (HCC) growth via inhibiting alternative activation of tumor-associated macrophages. Journal of Biological Chemistry, 2012, 287(48): p. 40140-40149. Dai H.R., Zhou Y., Tong C., Guo Y.L., Shi F.X., Wang Y., Shen P.P.*, Restoration of CD3+CD56+cell level improves skin lesions in severe psoriasis: A pilot clinical study of adoptive immunotherapy for patients with psoriasis using autologous cytokine-induced killer cells. Cytotherapy, 2018, 20: p. 1155-1163.