景键 - 南京大学 - 生命科学学院

个人简介

Jian Jing is a professor at the School of Life Sciences of Nanjing University in China. He is a leading expert in systems neuroscience, with extensive experience in circuitry studies in invertebrate model systems at the University of Illinois and Mount Sinai School of Medicine at New York. He graduated from Peking University with B.Sc. in 1987, and had studied hypoxia/ischemia in rat hippocampal slices at Beijing Neurosurgical Institute and Duke University. He obtained his Ph.D. from University of Illinois in 1998. He has published extensively in journals such as Curr Biol, J Neurosci, Anal Chem, ACS Chem Biol, ACS Chem Neurosci, JBC, J Neurophysiol, PLOS ONE, and has edited a book titled “Network Functions and Plasticity: Perspectives from Studying Neuronal Electrical Coupling in Microcircuits” published by Academic Press/Elsevier in 2017. He currently directs a research program that examines neural circuits underlying motivated behaviors and neuromodulation at Nanjing University.

研究领域

行为/系统和细胞神经科学（Behavioral/Systems and Cellular Neuroscience） – 利用动物模型系统研究行为的神经机理（Studying neural basis of behavior using model systems）: 感觉运动整合（sensorimotor integration）, 运动协调（movement coordination）, 神经调节（neuromodulation）, 行为和环路可塑性（behavioral and circuit plasticity）; 动机 (motivation), 觉醒 (arousal), 决策(decision making) 等的神经机制

近期论文

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Checco J.W., Zhang G., Yuan W-D., Le Z-W., Jing J. *, Sweedler J.V.* , Aplysia allatotropin-related peptide and its newly identified d-amino acid–containing epimer both activate a receptor and a neuronal target, J. Biol. Chem. , 293 , 16862−16873, (2018). Checco J.W., Zhang G., Yuan W-D., Yu K., Yin S-Y., Roberts-Galbraith R.H., Yau P.M., Romanova E.V., Jing J. * , Sweedler J.V. * , Molecular and physiological characterization of a receptor for D‑amino acid-containing neuropeptides, ACS Chem. Biol. , 13 , 1343-1352, (2018). Zhang G., Yuan W-D., Vilim F.S., Romanova E.V., Yu K., Yin S-Y., Le Z-W., Xue Y-Y., Chen T-T., Chen G-K., Chen S-A., Cropper E.C., Sweedler J.V., Weiss K.R., Jing J. * , Newly identified Aplysia SPTR-Gene Family-Derived Peptides: localization and function, Aplysia, ACS Chem. Neurosci. , 9 , 2041-2053, (2018). Zhang G., Vilim F.S., Liu D-D, Romanova E.V., Yu K., Yuan W-D., Xiao H., Chen T-T., Alexeeva V.Y., Yin S-Y., Chen S-A., Cropper E.C., Sweedler J.V., Weiss K.R., Jing J. * , Discovery of leucokinin-like neuropeptides that modulate a specific parameter of feeding motor programs in the molluscan model, Aplysia, J. Biol. Chem. , 292 , 18775−18789, (2017). Livnat I., Tai H-C., Jansson E. T., Bai L., Romanova E.V., Chen T-T., Yu K., Chen S-A., Zhang Y., Wang Z-Y., Liu D-D., Weiss K.R., Jing J. * , Sweedler J.V. * , A D-amino acid-containing neuropeptide discovery funnel, Anal. Chem. , 88 , 11868−11876, (2016). Siniscalchi M.J., Cropper E.C., Jing J., Weiss K.R., Repetition priming of motor activity mediated by a central pattern generator: the importance of extrinsic vs. intrinsic program initiators, J. Neuro physiol. ,116 , 1821–1830, (2016). Yang C-Y., Yu K., Wang Y., Chen S-A., Liu D-D., Wang Z-Y., Su Y-N., Yang S-Z., Chen T-T., Livnat I., Vilim F.S., Cropper E.C., Weiss K.R., Sweedler J.V., Jing J. * , Aplysia locomotion: network and behavioral actions of GdFFD, a D-amino acid-containing neuropeptide, PloS One , 11 , e0147335, (2016). Jing J. * , Alexeeva V.Y., Chen S-A., Yu K., Due M.R., Tan L-N., Chen T-T., Liu D-D., Cropper E.C., Vilim F.S., Weiss K.R., Functional characterization of a vesicular glutamate transporter in an interneuron that makes excitatory and inhibitory synaptic connections in a molluscan neural circuit, J. Neurosci., 35 , 9137–9149, (2015). Wu J-S., Wang N, Siniscalchi M.J., Perkins M.H., Zheng Y-T., Yu W., Chen S-A., Jia R-N., Gu J-W., Qian Y-Q., Ye Y., Vilim F.S., Cropper E.C., Weiss K.R., Jing J. * , Complementary interactions between command-like interneurons that function to activate and specify motor programs, J. Neurosci., 34, 6510–6521, (2014). (Featured in THIS WEEK IN THE JOURNAL ) Bai L., Livnat I., Romanova E.V.,Alexeeva V.Y., Yau P.M., Vilim F.S., Weiss K.R., Jing J. * , Sweedler J.V. *, Characterization of GdFFD, a D-amino acid-containing neuropeptide that functions as an extrinsic modulator of the Aplysia feeding circuit, J. Biol. Chem. , 288 , 32837–32851, (2013). Sasaki K., Cropper E.C., Weiss K.R., Jing J. * , Functional differentiation of a population of electrically coupled heterogeneous elements in a microcircuit, J. Neurosci., 33, 93-105, (2013). (Featured in THIS WEEK IN THE JOURNAL ) Jing J. * , Sweedler J.V., Cropper E.C., Alexeeva V., Park J.H., Romanova E., Xie F., Dembrow N.C., Ludwar B.C., Weiss K.R., Vilim F.S., Feedforward compensation mediated by the central and peripheral actions of a single neuropeptide discovered using representational differences analysis, J. Neurosci., 30, 16545-16558, (2010). On the COVER of Dec 8 issue of J Neurosci. Sasaki K., Brezina V., Weiss K.R., Jing J.* , Distinct inhibitory neurons exert temporally specific control over activity of a motoneuron receiving concurrent excitation and inhibition, J. Neurosci., 29, 11732-11744, (2009). (Featured in THIS WEEK IN THE JOURNAL and FACULTY OF 1000 BIOLOGY ) Jing J. * , Vilim F.S., Cropper E.C., Weiss K.R., Neural analog of arousal: persistent conditional activation of a feeding modulator by serotonergic initiators of locomotion, J. Neurosci., 28, 12349-12361, (2008). Jing J. * , Vilim F.S., Horn C., Alexeeva V.Y., Hatcher N.G., Sasaki K., Yashina I., Zhurov Y., Kupfermann I., Sweedler J.V., Weiss K.R., From hunger to satiety: reconfiguration of a feeding network by Aplysia neuropeptide Y, J. Neurosci., 27, 3490–3502, (2007). (Recommended by FACULTY OF 1000 BIOLOGY ) Jing J. * , Weiss K.R., Generation of variants of a motor act in a modular and hierarchical motor network, Curr. Biol., 15, 1712–1721, (2005). (Featured in BBC NEWS and Eurek Alert!) Jing J. * , Cropper E.C., Hurwitz I., Weiss K.R., The construction of movement with behavior-specific and behavior-independent modules, J. Neurosci., 24, 6315-6325, (2004). Jing J. * , Gillette R., Directional avoidance turns encoded by single interneurons and sustained by multifunctional serotonergic cells, J. Neurosci., 23, 3039-3051, (2003).