闵乾昊 - 南京大学 - 化学化工学院

个人简介

1986年生，教授，博士生导师，国家优秀青年基金获得者。2007年获南京大学理学学士学位，2012年获南京大学理学博士学位，2012年4月留校担任助理研究员。2013-2014年赴斯坦福大学化学系从事访问学者研究（合作导师：Richard N. Zare）。2015年任副教授，2022年任教授。2016年获国家自然科学基金优秀青年科学基金项目资助。主要研究方向为纳米生物分析与质谱分析，包括基于新型纳米材料的生物分离分析、生物质谱分析以及药物可控递送研究。在Nat. Commun.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、ACS Nano、Chem. Sci.、Anal. Chem.等期刊发表论文40多篇。主持国家自然科学基金面上项目2项，重大研究计划培育项目1项。欢迎对纳米生物技术、质谱分析感兴趣的同学报考我的硕士、博士研究生，同时欢迎本科同学加入我们的研究团队。工作经历 2003. 9–2007. 6，南京大学，化学，学士学位 2007. 9–2012. 3，南京大学，化学，博士学位 2012. 4–2015. 3，南京大学，化学系，助理研究员 2013. 12–2015. 1，斯坦福大学，化学系，访问学者 2015. 4–2015. 7，南京大学，化学系，副研究员 2015. 8至今，南京大学，化学系，副教授

研究领域

主要研究方向为纳米生物分析与质谱分析，包括基于新型纳米材料的生物分离分析、生物质谱分析以及药物可控递送研究。多年来我们致力于通过纳米探针的合理设计与功能调控，发展生物质谱分析新方法与肿瘤诊疗新策略。开发纳米探针分离介质与信号编码载体，发展了细胞内蛋白酶、激酶、核酸等多元目标物同步质谱监测新方法，以及组织水平药物分子、代谢产物、蛋白酶质谱成像新策略；设计响应性层级结构纳米界面，构筑肿瘤细胞及微环境特征因子刺激-响应性纳米药物载体，提出了靶标特异性的多元药物递送与肿瘤微环境重构新范式。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Hu, X.; Chi, H.; Fu, X.; Chen, J.; Dong, L.; Jiang, S.; Li, Y.; Chen, J.; Cheng, M.; Min, Q.*; Tian, Y.*; Zhang, P.*, Tunable Multivalent Aptamer-Based DNA Nanostructures to Regulate Multi-Hetero Receptor-Mediated Tumor Recognition. J. Am. Chem. Soc. 2023, in press. Zhang, X.; Dong, Y.; Wang, Y.; Zhang, Z.; Zhang, X.; Zhu, J.-J.; Tian, Y.; Min, Q.*, Quality Control of Mass-Encoded Nanodevices by Compartmented DNA Origami Frames for Precision Information Coding and Logic Mapping. Angew. Chem. Int. Ed. 2023, e202313446. Xu, Z.; Dong, Y.; Ma, N.; Zhu, X.; Zhang, X.; Yin, H.; Chen, S.; Zhu, J.-J.*; Tian, Y.*; Min, Q.*, Confinement in Dual-Chain-Locked DNA Origami Nanocages Programs Marker-Responsive Delivery of CRISPR/Cas9 Ribonucleoproteins. J. Am. Chem. Soc. 2023, 145 (49), 26557-26568. Zhang, Q.; Wang, Y.; Wang, W.; Min, Q.*; Zhang, J.-R.*; Zhu, J.-J.*, A Telomerase-Assisted Strategy for Regeneration of DNA Nanomachines in Living Cells. Angew. Chem. Int. Ed. 2023, 62 (6), e202213884. Zhang, Z.; Xu, H.; Fan, Y.; Zhang, X.; Wang, W.; Zhu, J.-J.; Min, Q.*, Mass Nanotags Mediate Parallel Amplifications on Nanointerfaces for Multiplexed Profiling of RNAs. Nano Lett. 2023, 23 (5), 1820-1829. Huang, S.; Song, Y.; Chen, X.*; Min, Q.*; Zhang, J.-R.*; Zhu, J.-J.*, Synergistic Oxidative Damage with Gene Therapy Potentiates Targeted Sterilization of Broad-Spectrum Microorganisms. Adv. Funct. Mater. 2023, 33 (32), 2300145. Gao, D.; Tang, Z.; Chen, X.; Wu, R.; Tian, Y.; Min, Q.; Zhang, J.-R.; Chen, Z.*; Zhu, J.-J.*, Reversible Regulation of Long-Distance Charge Transport in DNA Nanowires by Dynamically Controlling Steric Conformation. Nano Lett. 2023, 23 (10), 4201-4208. Yin, H.; Chu, Y.; Wang, W.; Zhang, Z.; Meng, Z.; Min, Q.*, Mass tag-encoded nanointerfaces for multiplexed mass spectrometric analysis and imaging of biomolecules. Nanoscale 2023, 15 (6), 2529-2540. Du, H.; Liu, L.-X.; Li, P.; Min, Q.*; Guo, S.*; Zhu, W.*, Enriching Reaction Intermediates in Multishell Structured Copper Catalysts for Boosted Propanol Electrosynthesis from Carbon Monoxide. ACS Nano 2023, 17 (9), 8663-8670. Dai, L.; Hu, X.; Ji, M.; Ma, N.; Xing, H.; Zhu, J.-J.; Min, Q.; Tian, Y.*, Programming the morphology of DNA origami crystals by magnesium ion strength. Proc. Natl. Acad. Sci. U. S. A. 2023, 120 (28), e2302142120. Zhang, X.; Lu, W.; Ma, C.; Wang, T.; Zhu, J.-J.; Zare, R. N.; Min, Q.*, Insights into electrochemiluminescence dynamics by synchronizing real-time electrical, luminescence, and mass spectrometric measurements. Chem. Sci. 2022, 13 (21), 6244-6253. Xu, Z.; Huang, Y.; Yin, H.; Zhu, X.; Tian, Y.; Min, Q.*, DNA Origami-Based Protein Manipulation Systems: From Function Regulation to Biological Application. ChemBioChem 2022, 23 (9), e202100597. Xu, H.; Zhang, Z.; Wang, Y.; Zhang, X.; Zhu, J.-J.*; Min, Q.*, Sense and Validate: Fluorophore/Mass Dual-Encoded Nanoprobes for Fluorescence Imaging and MS Quantification of Intracellular Multiple MicroRNAs. Anal. Chem. 2022, 94 (16), 6329-6337. Li, K.; Cai, Y.; Yang, X.; Wang, S.; Teng, C.; Tian, Y.; Min, Q.; Zhu, W.*, H2S Involved Photocatalytic System: A Novel Syngas Production Strategy by Boosting the Photoreduction of CO2 While Recovering Hydrogen from the Environmental Toxicant. Adv. Funct. Mater. 2022, 32 (20), 2113002. Jin, Z.; Liu, M.; Huang, X.; Zhang, X.; Qu, Z.*; Zhu, J.-J.*; Min, Q.*, Top-Down Rational Engineering of Heteroatom-Doped Graphene Quantum Dots for Laser Desorption/Ionization Mass Spectrometry Detection and Imaging of Small Biomolecules. Anal. Chem. 2022, 94 (21), 7609-7618. Jiang, Y.-W.; Tang, W.-J.; Gao, G.; Geng, Y.-Q.; Wu, F.-G.; Min, Q.*; Zhu, J.-J.*, Lipid droplet-hitchhiking probe creates Trojan foam cells for fluorescence/photoacoustic imaging of atherosclerotic plaques. Biosens. Bioelectron. 2022, 216, 114613. Huang, S.; Song, Y.; Yao, H.; Min, Q.; Zhang, J.-R.*; Zhu, J.-J.*, Multistage Photoactivatable Zinc-Responsive Nanodevices for Monitoring and Regulating Dysfunctional Islet β-Cells. Anal. Chem. 2022,94 (17), 6607-6614. Gao, D.; Ma, N.; Yan, X.; Ji, M.; Zhu, J.-J.*; Min, Q.*; Tian, Y.*, Low-entropy lattices engineered through bridged DNA origami frames. Chem. Sci. 2022, 13 (1), 283-289. Du, H.; Liu, L.-X.; Cai, Y.; Wang, Y.; Zhang, J.-R.; Min, Q.; Zhu, W.*, In situ formed N-containing copper nanoparticles: a high-performance catalyst toward carbon monoxide electroreduction to multicarbon products with high faradaic efficiency and current density. Nanoscale 2022, 14 (19), 7262-7268. Dong, Y.; Liu, J.; Lu, X.; Duan, J.; Zhou, L.; Dai, L.; Ji, M.; Ma, N.; Wang, Y.; Wang, P.; Zhu, J.-J.; Min, Q.; Gang, O.; Tian, Y.*, Two-Stage Assembly of Nanoparticle Superlattices with Multiscale Organization. Nano Lett. 2022,22 (9), 3809-3817. Dong, Y.; Jin, Z.; Zhang, X.; Tang, Y.; Tian, Y.*; Zhu, J.-J.*; Min, Q.*, A six-plex switchable DNA origami cipher disk for tandem-in-time cryptography. Chem. Commun. 2022, 58 (41), 6124-6127. Zheng, F.; Meng, T.; Jiang, D.; Sun, J.; Yao, H.; Zhu, J.-J.; Min, Q.*, Nanomediator-Effector Cascade Systems for Amplified Protein Kinase Activity Imaging and Phosphorylation-Induced Drug Release In Vivo. Angew. Chem. Int. Ed. 2021, 60 (39), 21565-21574. Zhang, X.; Wang, W.; Zare, R. N.*; Min, Q.*, Peptide and protein assays using customizable bio-affinity arrays combined with ambient ionization mass spectrometry. Chem. Sci.2021,12 (32), 10810-10816. Xu, H.; Zhang, Z.; Wang, Y.; Lu, W.; Min, Q.*, Engineering of nanomaterials for mass spectrometry analysis of biomolecules. Analyst 2021, 146, 5779-5799. Liang, T.; Zhang, B.; Xing, Z.; Dong, Y.; Xu, H.; Chen, X.; Jiang, L.; Zhu, J.-J.; Min, Q.*, Adapting and Remolding: Orchestrating Tumor Microenvironment Normalization with Photodynamic Therapy by Size Transformable Nanoframeworks. Angew. Chem. Int. Ed. 2021, 60 (20), 11464-11473. Cai, Y.; Fu, J.; Zhou, Y.; Chang, Y.-C.; Min, Q.*; Zhu, J.-J.; Lin, Y.*; Zhu, W.*, Insights on forming N,O-coordinated Cu single-atom catalysts for electrochemical reduction CO2 to methane. Nat. Commun. 2021, 12 (1), 586. Zhang, K.; Lu, F.; Cai, Z.; Song, S.; Jiang, L.; Min, Q.*; Wu, X.*; Zhu, J.-J.*, Plasmonic Modulation of the Upconversion Luminescence Based on Gold Nanorods for Designing a New Strategy of Sensing MicroRNAs. Anal. Chem. 2020, 92 (17), 11795-11801. Xu, H.; Huang, X.; Zhang, Z.; Zhang, X.; Min, Q.*; Zhu, J.-J., Protease-responsive mass barcoded nanotranslators for simultaneously quantifying the intracellular activity of cascaded caspases in apoptosis pathways. Chem. Sci. 2020, 11 (20), 5280-5288. Zheng, F.; Wang, C.; Meng, T.; Zhang, Y.; Zhang, P.; Shen, Q.; Zhang, Y.; Zhang, J.; Li, J.; Min, Q.*; Chen, J.*; Zhu, J.-J.*, Outer-Frame-Degradable Nanovehicles Featuring Near-Infrared Dual Luminescence for in Vivo Tracking of Protein Delivery in Cancer Therapy. ACS Nano 2019, 13 (11), 12577-12590. Yao, Z.; Zhang, B.; Liang, T.; Ding, J.; Min, Q.*; Zhu, J.-J., Promoting Oxidative Stress in Cancer Starvation Therapy by Site-Specific Startup of Hyaluronic Acid-Enveloped Dual-Catalytic Nanoreactors. ACS Appl. Mater. Interfaces 2019, 11 (21), 18995-19005. Xu, H.; Liu, M.; Huang, X.; Min, Q.*; Zhu, J.-J., Multiplexed Quantitative MALDI MS Approach for Assessing Activity and Inhibition of Protein Kinases Based on Postenrichment Dephosphorylation of Phosphopeptides by Metal-Organic Framework-Templated Porous CeO2. Anal. Chem. 2018, 90 (16), 9859-9867. Liang, T.; Yao, Z.; Ding, J.; Min, Q.*; Jiang, L.*; Zhu, J.-J., Cascaded Aptamers-Governed Multistage Drug-Delivery System Based on Biodegradable Envelope-Type Nanovehicle for Targeted Therapy of HER2-Overexpressing Breast Cancer. ACS Appl. Mater. Interfaces 2018, 10 (40), 34050-34059. Ding, J.; Liang, T.; Min, Q.*; Jiang, L.*; Zhu, J.-J. “Stealth and Fully-Laden” Drug Carriers: Self-Assembled Nanogels Encapsulated with Epigallocatechin Gallate and siRNA for Drug-Resistant Breast Cancer Therapy. ACS Appl. Mater. Interfaces 2018, 10 (12), 9938-9948. Zheng, F.; Zhang, P.; Xi, Y.; Huang, K.; Min, Q.*; Zhu, J.-J.* Peptide-mediated core/satellite/shell multifunctional nanovehicles for precise imaging of cathepsin B activity and dual-enzyme controlled drug release. NPG Asia Mater. 2017, 9, e366. Ding, J.; Liang, T.; Zhou, Y.; He, Z.; Min, Q.*; Jiang, L. *; Zhu, J.-J. *, Hyaluronidase-triggered anticancer drug and siRNA delivery from cascaded targeting nanoparticles for drug-resistant breast cancer therapy. Nano Res. 2017, 10 (2), 690-703. Zhang, P.; Wang, C.; Zhao, J.; Xiao, A.; Shen, Q.; Li, L.; Li, J.; Zhang, J.; Min, Q.*; Chen, J.*; Chen, H.-Y.; Zhu, J.-J.*, Near Infrared-Guided Smart Nanocarriers for MicroRNA-Controlled Release of Doxorubicin/siRNA with Intracellular ATP as Fuel. ACS Nano 2016, 10 (3), 3637-3647. Zhang, P.; He, Z.; Wang, C.; Chen, J.; Zhao, J.; Zhu, X.; Li, C.-Z.; Min, Q.*; Zhu, J.-J.*, In Situ Amplification of Intracellular MicroRNA with MNAzyme Nanodevices for Multiplexed Imaging, Logic Operation, and Controlled Drug Release. ACS Nano 2015,9 (1), 789-798. Chen, Z.; Li, J.; Chen, X.; Cao, J.; Zhang, J.; Min, Q.*; Zhu, J.-J.*, Single Gold@Silver Nanoprobes for Real-Time Tracing the Entire Autophagy Process at Single-Cell Level. J. Am. Chem. Soc. 2015, 137 (5), 1903-1908. Chen, X.; Li, S.; Zhang, X.; Min, Q.*; Zhu, J.-J., Weaving a two-dimensional fishing net from titanoniobate nanosheets embedded with Fe3O4 nanocrystals for highly efficient capture and isotope labeling of phosphopeptides. Nanoscale 2015, 7 (13), 5815-5825. Zhang, P.; Cheng, F.; Zhou, R.; Cao, J.; Li, J.; Burda, C.; Min, Q.*; Zhu, J.-J.*, DNA-Hybrid-Gated Multifunctional Mesoporous Silica Nanocarriers for Dual-Targeted and MicroRNA-Responsive Controlled Drug Delivery. Angew. Chem. Int. Ed. 2014, 53 (9), 2371-2375. Li, J.; Wang, W.; Sun, D.; Chen, J.; Zhang, P.-H.; Zhang, J.-R.; Min, Q.*; Zhu, J.-J.*, Aptamer-functionalized silver nanoclusters-mediated cell type-specific siRNA delivery and tracking. Chem. Sci. 2013, 4 (9), 3514-3521.