Zheng, Fang - University of Kentucky

研究领域

Artificial Intelligence; QM calculation and MD simulation; kinetic modeling and systems biology Model-guided design and analysis of experiments Small-molecule drug design and discovery Biotherapeutic drug design, discovery and development; biopharmaceutics Drug candidate evaluation using chemical, biochemical, pharmacological and behavioral approaches

近期论文

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Chen X, Zheng X, Ding K, Zhou Z, Zhan C-G, Zheng F. (2017). A quantitative LC-MS/MS method for simultaneous determination of cocaine and its metabolites in whole blood. J. Pharm. Biomed. Anal., 134, 243-251. Wang G, Zhang T, Huang H, Hou S, Chen X, Zheng F, Zhan C-G. (2016). Plant expression of cocaine hydrolase-Fc fusion protein for treatment of cocaine abuse. BMC Biotechnology, 16, 72. doi: 10.1186/s12896-016-0302-9. Chen X, Zheng X, Zhan M, Zhou Z-Y, Zhan C-G, Zheng F. (2016). Metabolic enzymes of cocaine metabolite benzoylecgonine. ACS Chem. Biol., 11, 2186-2194. Zhang Y, Huang X, Han K, Zheng F, Zhan C-G. (2016). Free energy profiles of cocaine esterase-cocaine binding process by molecular dynamics and potential of mean force simulations. Chem. Biol. Interact., 259, 142-147. Chen X, Zheng X, Zhan C-G, Zheng F. (2016). Effects of a cocaine hydrolase engineered from human butyrylcholinesterase on metabolic profile of cocaine in rats. Chem. Biol. Interact., 259, 104-109. Zheng X, Chen X, Zheng F, Zhan C-G. (2016). Potential anti-obesity effects of a long-acting cocaine hydrolase. Chem. Biol. Interact., 259, 99-103. Chen X, Xue L, Hou S, Jin Z, Zhang T, Zheng F, Zhan C-G. (2016). Long-acting cocaine hydrolase for addiction therapy. Proc. Natl. Acad. Sci. USA, 113, 422-427. Yao J, Yuan Y, Zheng F, Zhan C-G. (2016). Unexpected reaction pathway for butyrylcholinesterase-catalyzed inactivation of "hunger hormone" ghrelin. Sci. Rep., 6, 22322. doi: 10.1038/srep22322. Zheng F, Zhan C-G. (2016). Cocaine Hydrolases Designed from Butyrylcholinesterase, In "Biologics to Treat Substance Use Disorders: Vaccines, Monoclonal Antibodies, and Enzymes"; Ivan D. Montoya, Ed. Springer, p 187-225. Chen X, Huang X, Geng L, Xue L, Hou S, Zheng X, Brimijoin S, Zheng F, Zhan C-G. (2015). Kinetic Characterization of a Cocaine Hydrolase Engineered from Mouse Butyrylcholinesterase. Biochemical Journal, 466, 243-251.