Tsodikov, Oleg - University of Kentucky

个人简介

By combining structural biology, biophysical chemistry and computation, Dr. Tsodikov’s group is working on understanding biological mechanisms involved in bacterial infection and cancer. The specific areas of interest are DNA replication, bacterial persistence and drug resistance in Mycobacterium tuberculosis and other bacterial pathogens, and mechanisms of oncogenic transcription factors. The basic scientific inquiry is fueling a target-based drug discovery effort in finding, characterizing and developing novel inhibitors of these processes. Oleg Tsodikov graduated summa cum laude from Moscow Institute of Physics and Technology with a M. S. in 1994 and joined the Ph.D. program in biophysics at the University of Wisconsin-Madison. His work in Professor Tom Record’s laboratory was focused on using biophysical chemistry and computational methods to study fundamental protein-DNA interactions involved in prokaryotic transcription initiation. From Wisconsin, Dr. Tsodikov moved to Harvard Medical School, where he was a postdoctoral fellow in Professor Tom Ellenberger’s group. At Harvard, he carried out structural and biochemical studies of human nucleotide excision repair proteins. Before joining the University of Kentucky, Dr. Tsodikov was an Assistant Professor at the Department of Medicinal Chemistry at the University of Michigan.

研究领域

DNA replication, repair and transcription Drug discovery Enzymology Structural biology Thermodynamics and kinetics of biological processes

近期论文

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Garzan A#, Willby MJ#, Ngo HX, Gajadeera C, Green KD, Holbrook SYL, Hou C, Posey JE*, Tsodikov OV* and Garneau-Tsodikova S. (2017) Combating Eis-mediated kanamycin resistance of M. tuberculosis by novel pyrrolo[1,5-a]pyrazine-based Eis inhibitors. ACS Infect. Dis. In press. (# first co-authors, * co-corresponding authors) Pang AH, Garneau-Tsodikova S and Tsodikov OV. (2017) In vitro assays to identify antibiotics targeting DNA metabolism. Methods Mol. Biol., 1520, 175-200. Garzan A, Willby MJ, Green KD, Gajadeera CS, Hou C, Tsodikov OV*, Posey JE* and Garneau-Tsodikova S*. (2016) Sulfonamide-based inhibitors of aminoglycoside acetyltransferase Eis abolish resistance to kanamycin in Mycobacterium tuberculosis. J. Med. Chem., 59, 10619-10628. (* co-corresponding authors) Garzan A, Willby MJ, Green KD, Tsodikov OV, Posey JE* and Garneau-Tsodikova S*. (2016) Discovery and optimization of two Eis inhibitor families as kanamycin adjuvants against drug-resistant M. tuberculosis. ACS Med. Chem. Lett., 7, 1219-1221. (* co-corresponding authors) Pang AH#, Garzan A#, Larsen MJ, McQuade TJ, Garneau-Tsodikova S* and Tsodikov OV*. (2016) Discovery of allosteric and selective inhibitors of inorganic pyrophosphatase from Mycobacterium tuberculosis. ACS Chem. Biol., 11, 3084-3092. (# first co-authors, * co-corresponding authors) Hou C, Weidenbach S, Cano KE, Wang Z, Mitra P, Ivanov DN*, Rohr J* and Tsodikov OV*. (2016) Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1. Nucleic Acids Res., 44, 8990-9004. (* co-corresponding authors) Willby MJ, Green KD, Gajadeera CS, Hou C, Tsodikov OV*, Posey JE* and Garneau-Tsodikova S*. (2016) Potent inhibitors of acetyltransferase Eis overcome kanamycin resistance in Mycobacterium tuberculosis. ACS Chem. Biol., 11, 1639-1646. (* co-corresponding authors) Meyer P, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau DB, Rajashankar K, Anderson KS, Baxter R, Blacklow S, Boggon T, Bonvin A, Borek D, Brett T, Caflisch A, Chang C-I, Chazin W, Corbett KD, Cosgrove M, Crosson S, Dhe-Paganon S, Di Cera E, Drennan C, Eck M, Eichman B, Fan Q, Ferre-D'Amare A, Fraser JS, Fromme JC, Garcia K, Gaudet R, Gong P, Harrison S, Heldwein E, Jia Z, Keenan R, Kruse A, Kvansakul M, McLellan J, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJB, Petosa C, Raman CS, Rapoport T, Roll-Mecak A, Rosen M, Rudenko G, Schlessinger J, Schwartz T, Shamoo Y, Sondermann H, Tao Y, Tolia N, Tsodikov OV, Westover KD, Wu H, Foster I, Maia F, Gonen T, Kirchhausen T, Diederichs K, Crosas M and Sliz P. (2016) Data publication with the structural biology data grid supports live analysis. Nat. Commun., 7, 10882. Weidenbach S, Hou C, Chen J-M, Tsodikov OV* and Rohr J*. (2016) Dimerization and DNA recognition rules of mithramycin and its analogues. J. Inorg. Biochem., 156, 40-47. (* co-corresponding authors) Hou C and Tsodikov OV. (2015) Structural basis for dimerization and DNA binding of transcription factor FLI1. Biochemistry, 54, 7365-7374.