Pauly, James - University of Kentucky

研究领域

Dr. Pauly's research interests are primarily focused on the neurobiological actions of nicotine. The CNS nicotinic cholinergic system is studied using techniques that include quantitative receptor autoradiography, quantitative in situ hybridization histochemistry, ion flux assays and behavioral analyses. Dr. Pauly's lab is currently studying 1) the effects of prenatal nicotine exposure on brain development 2) the actions of steroid hormones (adrenal and ovarian) on the number and functional status of brain nicotinic receptor subtypes 3) the role of alpha 7 nicotinic receptors in regulating responsiveness to nicotine and 4) the brain nicotinic system in neurodegenerative conditions such as Alzheimer's and Parkinson's Disease. Dr. Pauly is also interested in the use of novel radioligands for the histochemical localization of receptor subtypes in the CNS as well as peripheral tissues such as the lung and heart.

近期论文

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Schober M E, Requena D F, Abdullah O M, Casper T C, Beachy J, Malleske D, Pauly James R. (2016). Dietary Docosahexaenoic Acid Improves Cognitive Function, Tissue Sparing, and Magnetic Resonance Imaging Indices of Edema and White Matter Injury in the Immature Rat after Traumatic Brain Injury. Journal of neurotrauma, 33(4), 390-402. Huber K B, Uteshev V V, Pauly James R. (2016). Targeting the Cholinergic System for Neuroprotection and/or Enhancement of Functional Recovery Following Neurotrauma. Current pharmaceutical design, 22(14), 2072-82. Berry J N, Saunders M A, Sharrett-Field Lynda, Reynolds A R, Bardo Michael, Pauly James R, Prendergast Mark. (2016). Corticosterone enhances N-methyl-D-aspartate receptor signaling to promote isolated ventral tegmental area activity in a reconstituted mesolimbic dopamine pathway. Brain research bulletin, 120, 159-65. Kang Nayon, Pauly James R, Feola David J. (2015). Effects of in utero nicotine exposure on immune responses. Proceedings of the 44th Autumn Immunology Conference, Mohajeri M H, Eckert G P, Pauly James R, Butt C M. (2015). Pharmacology: The Pharmacodynamics of Nutrients and Nutrient Interactions in Biological Functions. BioMed research international, 2015, 974572. Pandya J D, Readnower R D, Patel Samirkumar Pravinbhai, Yonutas H M, Pauly James R, Goldstein G A, Rabchevsky Alexander G, Sullivan Patrick Giles. (2014). N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI. Experimental neurology, 257, 106-13. Pandya J D, Readnower R D, Patel Samirkumar Pravinbhai, Yonutas H M, Pauly James R, Goldstein G A, Rabchevsky Alexander G, Sullivan Patrick Giles. (2014). N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI. Experimental neurology, 257, 106-13. Butler T R, Berry J N, Sharrett-Field Lynda, Pauly James R, Prendergast Mark. (2013). Long-term ethanol and corticosterone co-exposure sensitize the hippocampal ca1 region pyramidal cells to insult during ethanol withdrawal in an NMDA GluN2B subunit-dependent manner. Alcoholism, clinical and experimental research, 37(12), 2066-73. Butler T R, Berry J N, Sharrett-Field Lynda, Pauly James R, Prendergast Mark. (2013). Long-term ethanol and corticosterone co-exposure sensitize the hippocampal ca1 region pyramidal cells to insult during ethanol withdrawal in an NMDA GluN2B subunit-dependent manner. Alcoholism, clinical and experimental research, 37(12), 2066-73. Rowe R K, Harrison J L, Thomas T C, Pauly James R, Adelson P D, Lifshitz Jonathan. (2013). Using anesthetics and analgesics in experimental traumatic brain injury. Lab animal, 42(8), 286-91.