Marsac, Patrick - University of Kentucky

个人简介

Having received a B.S. in Chemical Engineering (2001) and a M.S. in Pharmaceutical Engineering (2002) from the University of Michigan, Patrick Marsac then graduated from Purdue University with a Ph.D. in Industrial and Physical Pharmacy (2007). He worked at Merck and Co. for 8 years and then joined UKY College of Pharmacy in September of 2015.

研究领域

Advanced analytics of materials and associated implications in drug discovery and development. Application of engineering principles to biological systems. Thermodynamics and kinetics of phase changes of solid state pharmaceutical products.

近期论文

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Nie H, Xu W, Taylor L S, Marsac Patrick Jules, Byrn S R. (2016). Crystalline solid dispersion-a strategy to slowdown salt disproportionation in solid state formulations during storage and wet granulation. International journal of pharmaceutics, Nie H, Su Y, Zhang M, Song Y, Leone A, Taylor L S, Marsac Patrick Jules, Li T, Byrn S R. (2016). Solid-State Spectroscopic Investigation of Molecular Interactions between Clofazimine and Hypromellose Phthalate in Amorphous Solid Dispersions. Molecular pharmaceutics, 13(11), 3964-3975. Nie H, Xu W, Ren J, Taylor L S, Marsac Patrick Jules, John C T, Byrn S R. (2016). Impact of Metallic Stearates on Disproportionation of Hydrochloride Salts of Weak Bases in Solid-State Formulations. Molecular pharmaceutics, 13(10), 3541-3552. Mitra A, Li L, Marsac Patrick Jules, Marks B, Liu Z, Brown C. (2016). Impact of polymer type on bioperformance and physical stability of hot melt extruded formulations of a poorly water soluble drug. International journal of pharmaceutics, 505(1-2), 107-14. Nie H, Liu Z, Marks B C, Taylor L S, Byrn S R, Marsac Patrick Jules. (2016). Analytical approaches to investigate salt disproportionation in tablet matrices by Raman spectroscopy and Raman mapping. Journal of pharmaceutical and biomedical analysis, 118, 328-37. Yildiz H M, McKelvey C A, Marsac Patrick Jules, Carrier R L. (2015). Size selectivity of intestinal mucus to diffusing particulates is dependent on surface chemistry and exposure to lipids. Journal of drug targeting, 23(7-8), 768-74. Boersen Nathan, Brown Chad, DiNunzio James, Johnson David, Marsac Patrick Jules, McKelvey Craig, Meyer Robert. (2014). Hot-Melt Extrusion: The Process-Product-Performance Interplay. Springer Scientific, Brown Chad, DiNunzio James, Eglesia Mike, Forster Seth, Lamm Matthew, Lowinger Michael, Marsac Patrick Jules, McKelvey Craig, Meyer Robert, Schenck Luke, Terife Graciela, Troup Gregory, Smith-Goettler Brandy, Starbuck Cindy. (2014). HME for Solid Dispersions: Composition and Design Considerations. Springer Scientific, Brown Chad, DiNunzio James, Eglesia Mike, Forster Seth, Lamm Matthew, Lowinger Michael, Marsac Patrick Jules, McKelvey Craig, Meyer Robert, Schenck Luke, Terife Graciela, Troup Gregory, Smith-Goettler Brandy, Starbuck Cindy. (2014). HME for Solid Dispersions: Scale-Up and Late-Stage Development. Springer Scientific, Ilevbare Grace, Marsac Patrick Jules, Mitra Amitava. (2014). Performance and Characterization of Solid Dispersions: An Overview. Springer Scientific,