DeMali, Kris - University of Iowa - Department of Biochemistry

个人简介

Education BA, Chemistry, The College of Wooster PhD, Pharmacology, University of Colorado Health Sciences Center Post Doctoral Fellow, Molecular & Cell Biology, University of North Carolina

研究领域

Cell-cell interactions affect many aspects of cell behavior, including growth, differentiation and the establishment of normal tissue architecture. Loss of expression or function of components present in cell-cell interactions has been found in carcinomas and correlates with poor prognostic outcome in cancer patients. Cells have several mechanisms for linking to their neighbors. These so-called "cell junctions" consist of proteins that assemble into different structures such as gap junctions, tight junctions, adherens junctions, desmosomes and hemidesmosomes, each with specialized functions. Cell-cell junctions of the zonula adherens are prominent in epithelia and are rich in transmembrane adhesive receptors known as cadherins. The cytoplasmic tail of cadherins binds numerous proteins that serve as molecular couplers, linking cell surface adhesion and recognition to both the actin cytoskeleton and cell signaling pathways. A major focus of the work in my lab is to understand cellular mechanisms involved in assembly and maintenance of cell-cell adhesions by examining the function and regulation of proteins recruited to the cytoplasmic face of cadherins.

近期论文

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Jannie, K. M., Ellerbroek, S. M., Zhou, D. W., Chen, S., Crompton, D. J., García, A. J. & DeMali, K. A. (2015). Vinculin-dependent actin bundling regulates cell migration and traction forces.. The Biochemical journal, 465(3), 383-93. DOI: 10.1042/BJ20140872. Bays, J. L., Peng, X., Tolbert, C. E., Guilluy, C., Angell, A. E., Pan, Y., Superfine, R., Burridge, K. & DeMali, K. A. (2014). Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions. (Vols. 205). (2), pp. 251-63. J Cell Biol. DOI: 10.1083/jcb.201309092. DeMali, K. A., Sun, X. & Bui, G. A. (2014). Force transmission at cell-cell and cell-matrix adhesions. Biochemistry, 53(49), 7706-17. DOI: 10.1021/bi501181p. Mahauad-Fernandez, W. D., DeMali, K. A., Olivier, A. K. & Okeoma, C. M. (2014). Bone marrow stromal antigen 2 expressed in cancer cells promotes mammary tumor growth and metastasis. Breast Cancer Res, 16(6), 493. Biggs, L. C., Naridze, R. L., DeMali, K. A., Lusche, D. F., Kulh, S., Soll, D. R., Schutte, B. C. & Dunnwald, M. (2014). Interferon regulatory factor 6 regulates keratinocyte migration. J Cell Sci, 127(13), 2840-8. DOI: 10.1242/jcs.139246. Maiers, J. L., Peng, X., Fanning, A. S. & DeMali, K. A. (2013). ZO-1 recruitment to a-catenin: a novel mechanism for coupling the assembly of tight junctions to adherens junctions. Journal of cell science, Epub ahead of print. Johnston, J. J., Wen, K. K., Keppler-Noreuil, K., McKane, M., Maiers, J. L., Greiner, A., Sapp, J. C., DeMali, K., Rubenstein, P. & Biesecker, L. (2013). Functional Analysis of a De Novo ACTB Mutation in a Patient with Atypical Baraitser-Winter Syndrome. Human mutation, 34(9), 1242-1249. Peng, X., Maiers, J. L., Choudhury, D., Craig, S. W. & DeMali, K. A. (2012). a-Catenin uses a novel mechanism to activate vinculin. The Journal of biological chemistry, 287(10), 7728-37. Sloan, C. M., Quinn, C. V., Peters, J. P., Farley, J., Goetzinger, C., Wernli, M., DeMali, K. A. & Ellerbroek, S. M. (2012). Divergence of Rho residue 43 impacts GEF activity. Small GTPases, 3(1), 15-22.