Mallapragada, Surya - IOWA State University - Chemical and Biological Engineering

个人简介

Honors and Awards Fellow, National Academy of Inventors, 2016 WiSE Champion, Program for Women in Science and Engineering, 2016 Clare Booth Luce Scholarship Award, Higher Education Resource Services, 2016 David Boylan Eminent Faculty Award for Research, Iowa State University, 2014 Young Alumni Achievement Award, IIT Bombay, 2011 Distinguished Service Award, Food, Pharmaceutical and Bioengineering Division, AIChE Stanley Chair in Interdisciplinary Engineering, 2009 - 2015 Fellow, American Association for Advancement of Science, 2008 Member, NIH Study Section, Biomaterials & Biointerfaces, 2006-2010 Mid-Career Excellence in Research Award, ISU Foundation, 2007 Big 12 Rising Star Award, 2007 Invited participant, National Academy of Engineering, Frontiers in Engineering Conference, 2006 Fellow, AIMBE, 2006 Global Indus Technovator Award, 2003 Named by MIT's Technology Review Magazine as one of the World's Top 100 Young Innovators, 2002 3M Non-tenured Faculty Award, 2001 Early Achievement in Research Award, ISU Foundation, 2001 NSF Faculty Early CAREER Award, 2000 Andrews Graduate Fellowship, Purdue University, 1993-1995

研究领域

Our research program is focused on designing polymeric biomaterials and bioinspired materials. Our current focus areas are: Smart Polymers for Delivery of Genetic Material: We have designed and synthesized novel smart bioinspired multi-block copolymers that exhibit pH and temperature sensitivity. These polymers are cationic and undergo thermoreversible gelation at body temperatures These cationic polymers exhibit complexation with nucleic acids and serve as excellent injectable sustained delivery vectors of combiantions of miRNA or siRNA with chemotherapeutic agents for pancreatic cancer therapies. These copolymers also exhibit selective transfection in cancer cells. Polymers for Vaccine Delivery: This project focuses on developing sustained vaccine delivery devices for single-dose sub-unit vaccines. We have designed virus-mimicking block copolymer-based nanovaccines for influenza that act as effective adjuvants to stimulate the immune system and confer protection. Bioinspired Nanocomposites: This multi-investigator project focuses on the synthesis as well as the hierarchical self-assembly of nanoparticles into 2D and 3D structures using a combination of stimuli-responsive synthetic block copolymers and biomolecules. Combating Neurodegeneration: Our approach involves utilizing a combination of physical, chemical, biological and electrical cues on polymer substrates to facilitate peripheral nerve regeneration, and control adult stem cell differentiation to combat neurodegeneration. Our recent work has showed that physical cues in the form of micropatterned substrates, in synergy with other cues such as electrical, can control differentiation of adult stem cells. We are also developing strategies to deliver therapeutics across the blood-brain barrier to combat neurodegeneration.

近期论文

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Zhang, H., Wang, W., Mallapragada, S.K., Travesset, A., and Vaknin, D., “Macroscopic and Tunable Nanoparticle Superlattices”, Nanoscale. http://pubs.rsc.org/en/content/articlehtml/2017/nr/c6nr07136h Uz, M., Sharma, A., Adhikari, P., Sakaguchi, D., and Mallapragada, S.K., “Development of Multifunctional Films for Peripheral Nerve Regeneration Conduits, Acta Biomat. http://dx.doi.org/10.1016/j.actbio.2016.09.039 Zhang, H., Wang, W., Hagen, N., Kuzmenko, I., Akinc, M., Travesset, A., Mallapragada, S.K., and Vaknin, D., “Self-assembly of DNA-functionalized Gold Nanoparticles at the Air-Water Interface”, Advanced Materials Interfac., 3, 1600180 (2016). http://onlinelibrary.wiley.com/doi/10.1002/admi.201600180/full Wang, W., Zhang, H., Kuzmenko, I., Mallapragada, S., and Vaknin, D., “Assembling Bare Au Nanoparticles at Positively Charged Templates”, Rep, 6, 26462 (2016). http://www.nature.com/articles/srep26462 Ross, K., Adams, J.,Loyd, H., Ahmed, S., Sambol, A., Broderick, S., Rajan, K., Kohut, M., Bronich, T., Carpenter, S., Wannemuehler, M., Narasimhan, B., and Mallapragada, S.K., “Combination Nanovaccine Demonstrates Synergistic Enhancement in Efficacy Against Influenza”, ACS Biomaterials Sci. Eng., 2, 368-374 (2016). http://pubs.acs.org/doi/pdfplus/10.1021/acsbiomaterials.5b00477 Renukaradhya, G., Narasimhan, B., and Mallapragada, S.K., “Respiratory Nanoparticle-Based Vaccines and Challenges Associated with Animal Models and Translation”, J. Controlled Rel. (Americas special edition), 219, 622-631 (2015). http://www.sciencedirect.com/science/article/pii/S0168365915301474 Mallapragada, S.K., Brenza, T., McMillan, J., Narasimhan, B., Sakaguchi, D., Sharma, A., Zbarska, S., and Gendelman, H., “Enabling Nanomaterial, Nanofabrication and Cellular Technologies for Nanoneuromedicine”, Nanomedicine: Nanotechnology, Biology and Medicine, 11, 715-725 (2015).http://www.sciencedirect.com/science/article/pii/S1549963415000192 Gendelman, H., Anantaram, V., Brenza, T., Bronich, T., Ghaisas, S., Jin, H., Kanthasamy, A., Liu, X., McMillan, J., Mosley, R.L., Narasimhan, B., and Mallapragada, S.K. “Nanoneuromedicines for Degenerative, Inflammatory and Infectious Disorders of the Nervous System”, Nanomedicine: Nanotechnology, Biology and Medicine, 11, 751-767 (2015). http://www.nanomedjournal.com/article/S1549-9634(15)00020-9/fulltext Adams, J., Haughney, S., and Mallapragada, S.K., “Effective Polymer Adjuvants for Sustained Delivery of Protein Subunit Vaccines”, Acta Biomat., 14, 104-114 (2015). http://www.sciencedirect.com/science/article/pii/S1742706114005534