个人简介
1999年硕士研究生毕业后任职于上海医科大学药学院（2001年改为复旦大学药学院）至今。2008获复旦大学生物化学与分子生物学博士学位。2009年11月至2011年1月于纽约州立大学下州医学中心研修访问。历任助教、讲师、高级实验师等职务。除理论与实验教学外，主要从事脂类代谢与药物开发研究。参加国家自然科学基金14项，主持上海市自然科学基金1项，论文主要发表于JLR，ATVB，JBC，JMC，EJMC等国际主流权威杂志。参与SMS与LPCAT3活性药物的研发，其中SMS抑制剂已成功转让给某医药企业，合同总价1.5亿元。
近期论文
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胡傢椿, 董继斌, 楼滨, 李英霞, 蒋宪成, 丁庭波#《溶血血小板活化因子乙酰基转移酶（LPAFAT）活性检测方法的比较》复旦学报医学版， 2020， 47（3），411-418.
Du Xinming, Hu Jiachun, Zhang Qing, Liu Qi, Xiang Xinin, Dong Jibin, Lou Bin, He Shuhua, Gu Xiang, Cao Yu, Li Yingxia, Ding Tingbo#.A novel assay for measuring recombinant human lysophosphatidylcholine acyltransferase 3 activity.FEBS Open Bio. 2019 Oct;9(10):1734-1743.
Yali Li, Taomin Huang, Bin Lou, Deyong Ye, Xiangyu Qi, Xiaoxia Li, Shuang Hu, Tingbo Ding, Chen Yan, Yang Cao, Mingguang Mo, Dong Jibin, Min Wei, Yong Chu, Huiti Li, Jiang Xian-Cheng, Nengneng Cheng, Lu Zhou. Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor. Eur J Med Chem. 2019, 163, 864-882.
Bin Lou, Qi Liu, Jiahui Hou, Inamul Kabir, Peipei Liu, Tingbo Ding, Jibin Dong, Mingguang Mo, Ye Deyong, Yang Chen, Hai H. Bui, Kenneth Roth, Yu Cao, Xian-Cheng Jiang.2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity. J Biol Chem. 2018, 293(47), 18328-18336.
Chunyan Feng, Bin Lou, Jibin Dong, Zhiqiang Li, Yunqin Chen, Yue Li, Xuemei Zhang, Xian-Cheng Jiang, Tingbo Ding#. Lysophosphatidylcholine acyltransferase 3 deficiency impairs 3T3L1 cell adipogenesis through activating Wnt/β-catenin pathway. BBA - Molecular and Cell Biology of Lipids 1863 (8) 834–843.
Zhiqiang Li, Hui Jiang, Tingbo Ding , Caixia Lou, Bui HH, Ming-Shang Kuo, Xian-Cheng Jiang. Deficiency in Lysophosphatidylcholine Acyltransferase 3 Reduces Plasma Levels of Lipids by Reducing Lipid Absorption in Mice.Gastroenterology. 2015 Nov;149(6):1519-29.
Yali Li , Xiangyu Qi, Hui Jiang,Xiaodong Deng,Dong Yanping, Tingbo Ding, Lu Zhou , Peng Men, Yong Chu, Renxiao Wang, Xian-Cheng Jiang, Deyong Ye. Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors. Bioorg Med Chem. 2015 Sep 15;23(18):6173-84.
Tingbo Ding *, Inamul Kabir I *, Yue Li *, Caixia Lou, Amirfarbod Yazdanyar, Jiachen Xu, Jibin Dong, Hongwen Zhou, Taesik Park, Mohamed Boutjdir, Zhiqiang Li, Xian-Cheng Jiang. All members in Sphingomyelin Synthase Gene Family Have Ceramide Phosphoethanolamine Synthase Activity.J Lipid Res. 2015 Mar;56(3):537-45.
Tingbo Ding#, Jibin Dong, Bin Lou, Xian-Cheng Jiang. Sphingomyelin synthase activity measurement by the fluorescent product in cell culture medium or animal plasma. J. Chin. Pharm. Sci. 2014,23(4),256-261
Xiaodong Deng,Fu lin, Ya Zhang,Yan Li, Lu Zhou, Bin Lou, Yue Li, Jibin Dong, Tingbo Ding,Xiancheng Jiang, Renxiao Wang, Deyong Ye. Identification of small molecule sphingomyelin synthase inhibitors. Eur J Med Chem. 2014 Feb 12;73:1-7.
Yue Li*,Jibin Dong*,Tingbo Ding*, Ming-Shang Kuo, Guoqing Cao,Xian-Cheng Jiang, Zhiqiang Li.Sphingomyelin synthase 2 activity and liver steatosis: an effect of ceramide-mediated peroxisome proliferator-activated receptor γ2 suppression.Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1513-20.
Zhiqiang Li*, Tingbo Ding*, Xiaoyue Pan*, Yan Li, Ruohan Li, Philip E. Sanders, Ming-Shang Kuo, M. Mahmood Hussain, Guoqing Cao, and Xian-Cheng Jiang. Lysophosphatidylcholine acyltransferase 3 knockdown-mediated liver lysophosphatidylcholine accumulation promotes very low density lipoprotein production by enhancing microsomal triglyceride transfer protein expression.J Biol Chem. 2012 Jun 8;287(24):20122-31.
Calvin Yeang, Tingbo Ding, William J Chirico, and Xian-Cheng Jiang.Subcellular Targeting Domains of Sphingomyelin Synthase 1 and 2. Nutr Metab (Lond). 2011 Dec 14;8:89.
Tinbo Ding, Zhiqiang Li, Tiruneh Hailemariam, Sushmita Mukherjee, Frederick R. Maxfield, Man-Ping Wu, and Xian-Cheng Jiang. SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism,and cell apoptosis. J Lipid Res. 2008 Feb;49(2):376-85.
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