史训龙 - 复旦大学

个人简介

教育经历 1998.09 – 2002.07 复旦大学药学院（原上海医科大学药学院）学士 2002.09 – 2008.07 复旦大学药学院硕博连读 2007.1– 2008.01 美国University of the Pacific 访问学者工作经历 2008.7-2014.12 复旦大学药学院，讲师 2014.12-至今复旦大学药学院，副教授

研究领域

基因工程技术药物研发及应用：重组生物大分子如治疗酶，疫苗等在病毒性疾病中的应用药物抗病毒机制的研究：天然药物小分子或重组生物大分子对宿主炎症通路或免疫应激调控

近期论文

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Hai Huang, Wei Zhou, Haiyan Zhu, Pei Zhou and Xunlong Shi, Baicalin benefits the anti-HBV therapy via inhibiting HBV viral RNAs, Toxicol Appl Pharmacol., 2017, 323: 36-43 Xunlong Shi, Wei Zhou, Hai Huang, Hongguang Zhu, Pei Zhou, Haiyan Zhu, Dianwen Ju. Inhibition of the inflammatory cytokine TNF-alpha with etanercept provides protection against lethal H1N1 influenza infection in mice. Crit Care 2013, 17: R301 Xunlong Shi, Zhihui Shi, Hai Huang, Hongguang Zhu, Pei Zhou, Haiyan Zhu, Dianwen Ju. Ability of recombinant human catalase to suppress inflammation of the murine lung induced by influenza A. Inflammation 2013, 37(3): 809-17 Xunlong Shi, Zhihui Shi, Hai Huang, Hongguang Zhu, Haiyan Zhu, Dianwen Ju, Pei Zhou. PEGylated human catalase elicits potent therapeutic effects on H1N1 influenza-induced pneumonia in mice. Appl Microbiol Biotechnol. 2013, 97: 10025-33, DOI: 10.1007/s00253-013-4775-3 Xun-Long Shi1, Zhi-Hui Shi1, Mei-Qing Feng, Li Ye, Hai-Yan Zhu, Ji-Yang Li, Dian-Wen Ju, Pei Zhou. High expression of recombinant human catalase and its immunomodulatory effects on H1N1 influenza virus infection. Process Biochem 2013, 48: 588- 92 6. Z Wang, X Shi1, Y Li, J Fan, X Zeng, Y Sun, S Wang, P Song, S Zhao, H Hu and D Ju，Blocking autophagy enhanced cytotoxicity induced by recombinant human arginase in triple-negative breast cancer cells。Cell Death Dis 2014, 5, e; doi:10.1038/cddis.2014.503 Xunlong Shi1, Jianjun Yang1, Haiyan Zhu, Li Ye, Meiqing Feng, Jiyang Li, Hai Huang, Qun Tao, Dan Ye, Lee-Hwei K Sun, Bill NC Sun, Cecily RY Sun, Guizhen Han, Yuanyuan Liu, Minghui Yao, Pei Zhou, Dianwen Ju. Pharmacokinetics and pharmacodynamics of recombinant human EPO-Fc fusion protein in vivo. Plos One 2013, DOI: 10.1371/journal.pone.0072673 Ziyu Wang1, Xunlong Shi1, Yubin Li, Xian Zeng, Jiajun Fan, Yun Sun, Zongshu Xian, Guoping Zhang, Shaofei Wang, Haifeng Hu, Dianwen Ju. Involvement of autophagy in recombinant human arginase-induced cell apoptosis and growth inhibition of malignant melanoma cells. Appl Microbiol Biotechnol. 2013, 98: 2485-2494 Wei Zhou, Xiaohui Liu, Pei Zhang, Pei Zhou and Xunlong Shi*, Effect Analysis of Mineral Salt Concentrations on Nosiheptide Production by Streptomyces actuosus Z-10 Using Response Surface Methodology. Molecules 2014, 19: 15507-15520 Wei Zhou, Xiaohui Liu, Li Ye, Meiqing Feng, Pei Zhou, Xunlong Shi*, The biotransformation of astragalosides by a novel acetyl esterase from Absidia corymbifera AS2. Process Biochemistry, 2014, 49: 1464-71 Weina Wang1, Xunlong Shi1, Yuan Yuan, Haiyan Zhu, Wei Zhou, Hai Huang, and Meiqing Feng. The inhibitory effect of apolipoprotein A-I on matrix metalloproteinase-2 expression in vivo and in vitro. Acta Biochim Biophys Sin 2013, 45: 194-202