Czarnik, Anthony W. - University of Nevada-Reno

个人简介

Sloan Fellow (1989); Camille and Henry Dreyfus Teacher-Scholar (1990) NIH Postdoctoral Fellow (1981–1983) Columbia University (R. Breslow) M.S. (1980); Ph.D. (1981), University of Illinois at Urbana/Champaign (N. Leonard) B.S. (1977), University of Wisconsin at Madison

研究领域

Current research interests include combinatorial chemistry as a tool for drug discovery, nucleic acids as targets for small molecule intervention, and fluorescent chemosensors of ion and molecule recognition. Dr. Czarnik is the founding editor of the Journal of Combinatorial Chemistry.

近期论文

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"Inhibitors of protein-RNA complexation that target the RNA: Specific recognition of HIV-1 TAR RNA by small organic molecules," Mei, H.-Y.; Cui, M.; Heldsinger, A.; Lemrow, S.M.; Loo, J.A.; Sannes-Lowery, K.A.; Sharmeen, L.; Czarnik, A.W. Biochemistry 1998, 37, 14204-14212. "Binding of neomycin to the TAR element of HIV-1 RNA induces dissociation of Tat protein by an allosteric mechanism," Wang, S.; Huber, P.W.; Cui, M.; Czarnik, A.W.; Mei, H.-Y. Biochemistry 1998, 37, 5549-5557. "Discovery of selective, small-molecule inhibitors of RNA complexes -- I. The Tat protein/TAR RNA complexes required for HIV-I transcription," Mei, H.-Y.; Mack, D.P.; Galan, A.A.; Halim, N.S.; Heldsinger, A.; Loo, J.A.; Moreland, D.W.; Sannes-Lowery, K.A.; Sharmeen, L.; Truong, H.N.; Czarnik, A.W. Bioorg. Med. Chem. 1997, 5, 1173. "Discovery of selective, small-molecule inhibitors of RNA complexes -- II. Self-splicing group I Intron ribozyme," Mei, H.-Y.; Cui, M.; Lemrow, S.M.; Czarnik, A.W. Bioorg. Med. Chem. 1997, 5, 1185. "Inhibition of self-splicing group I Intron RNA: High-throughput screening assays," Mei, H.-Y.; Cui, M.; Sutton, S. T.; Truong, H. N.; Chung, F-Z.; Czarnik, A. W. Nucleic Acids Res. 1996, 24, 5051. "Solid-phase synthesis of ureas on microtubes," Zhuang, H.; Yang, E.-C.; Xiao, X.-Y.; Czarnik, A.W.; Frye, L.L.; Zindell, R. Solid-Phase Org. Synth. 2001, 1, 15-40. "Kinetic study of organic reactions on polystyrene grafted microtubes," Li, W.; Czarnik, A.W.; Lillig, J.; Xiao, X.-Y. J. Comb. Chem. 2000, 2, 224-227. "Tubes and cubes, chips and tips: Tools for solid-phase organic synthesis," Czarnik, A.W. Methods Princ. Med. Chem. 2000, 7, 81-95. "A cyclitively cleavable linker for alcohols: Linker preparation and cleavage conditions," Xiao, X.; Nova, M.P.; Czarnik, A.W. J. Comb. Chem. 1999, 1, 379-382. "Kinetic comparison of amide formation on various crosslinked polystyrene resins," Li, W.; Xiao, X.; Czarnik, A.W. J. Comb. Chem. 1999, 1, 127-129. "Polystyrene grafted fluoropolymer microTubes: New supports for solid-phase organic synthesis with useful performance at high temperature," Zhao, C.; Shi, S.; Mir, D.; Hurst, D.; Li, R.; Xiao, X.; Lillig, J.; Czarnik, A.W. J. Comb. Chem. 1999, 1, 91-95. "Merrifield microtube reactors for solid phase synthesis," Li, R.; Xiao, X.; Czarnik, A.W. Tetrahedron Lett. 1998, 39, 8581-8584. "Combinatorial chemistry: What's in it for analytical chemists?" Czarnik, A.W. Analyt. Chem. 1998, 70, 378A-386A. "A combinatorial synthesis of tyrphostins via the ‘directed sorting' method," Shi, S.; Xiao, X.; Czarnik, A.W. Biotechnol. Bioeng. (Comb. Chem.) 1998, 61, 7-12. "Solid-phase synthesis supports are like solvents," Czarnik, A.W. Biotechnol. Bioeng. (Comb. Chem.) 1998, 61, 77-79. "Combinatorial chemistry," Czarnik, A.W.; Keene, J.D. Curr. Biol. 1998, 8, R705-R707. "Combinatorial chemistry," Czarnik, A.W.; Winograd, N. Entry in McGraw-Hill Yearbook of Science & Technology, 1998, p. 66. "Encoding strategies in combinatorial chemistry," Czarnik, A.W. Proc. Natl. Acad. Sci. 1997, 94, 12738. "No static at all: Electronic encoding in combinatorial organic synthesis," Czarnik, A.W.; Nova, M.P. Chem. Brit. 1997, 33, 39 . "New combinatorial methods - encoding," Czarnik, A.W. Curr. Op. Chem. Biol. 1997, 1, 60.