个人简介

DUCATION Spring 2007 Columbia University, Ph.D. in Physics Fall 2005 Columbia University, M. Phil. in Physics Fall 2000 National Taiwan University, M.S. in Physics Fall 1998 National Taiwan University, B.S. in Physics RESEARCH EXPERIENCE 2014-present Professor – Fudan University 2010-2013 Researcher – Fudan University Dynamics/function relationship of Proteins including enzymes and signalling proteins Development of new Single-molecule techniques 2007-2010 Postdoctoral Research Associate Host: Prof. Haw Yang, Princeton University Dynamics/function relationship of Adenylate Kinase (AK) Discovery of an Mg2+ ion activation mechanism in AK 2002-2006 Research Assistant Advisor: Prof. Horst Stormer, Columbia University Designing and fabricating GaAs/AlGaAs heterojunction insulated gate field effect transistors (HIGFET). Using HIGFET to measure GaAs many-body effective masses and spin susceptibility versus interaction strength at low temperatures (~10mK) and in high magnetic field. Discovery of a new type of high frequency magneto-oscillations in GaAs quantum wells. Discovery of an unconventional “half-integer” quantum Hall effect in electronic transport measurements of graphene, a single atomic layer of carbon.

研究领域

我们实验室科研方向着重在理解生物分子系统的运作原理。生物分子，尤其是蛋白质，可以在充满了变动与干扰的细胞中精确的执行多样化的功能。蛋白质分子能够高效率的运用环境中的能量，但是科学家并不理解其中的基础原理。我们将结合物理学背景与生物学中前沿的单分子萤光技术解决在生物与物理间跨领域的问题

实验生物物理

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

“Remarkable Antibacterial Activity of Reduced Graphene Oxide Functionalized by Copper Ions,” Y. Tu#*, P. Li#, J. Sun, J. Jiang, F. Dai, C. Li, Y. Wu, L. Chen, G. Shi, Y. Tan*, and H. Fang, Advanced Functional Materials 31, 13, 2008018 (2021). “Rational Design of Adenylate Kinase Thermostability through Coevolution and Sequence Divergence Analysis,” J. Chang#, C. Zhang#, H. Cheng, and Y.-W. Tan*, International Journal of Molecular Sciences 22, 5 (2021). “Engineering Single-Molecule Fluorescence with Asymmetric Nano-Antennas,” W. Zhao#, X. Tian#, Z. Fang#, S. Xiao, M. Qiu, Q. He, W. Feng, F. Li, Y. Zhang, L. Zhou*, and Y.-W. Tan*, Light: Science & Applications 10, 1 (2021). “State-of-the-Art Technologies for Understanding Brassinosteroid Signaling Networks.” H.Wang, S. Song, H. Cheng, and Y.-W. Tan*, International Journal of Molecular Sciences 21, 21 (2020). “Reactive oxygen species‐mediated BIN 2 activity revealed by single‐molecule analysis.” Song, S., Wang, H., Sun, M., Tang, J., Zheng, B., Wang, X., and Tan, Y.New Phytol. 223, 692–704 (2019). “Quantifying Intramolecular Protein Conformational Dynamics Under Lipid Interaction Using smFRET and FCCS.” Li P., Dai Y., Seeger M., Tan YW. (2019) In: Fratti R. (eds) SNAREs.Methods in Molecular Biology, vol 1860. Humana Press, New York, NY “Anomalous behavior of membrane fluidity caused by copper-copper bond coupled phospholipids,” Xiankai Jiang, Jinjin Zhang, Bo Zhou, Pei Li, Xiaojuan Hu, Zhi Zhu, Yanwen Tan, Chao Chang, Junhong Lü & Bo Song,Scientific Reports 8, 14903 (2018). “Single-Molecule Fluorescence Methods to Study Plant Hormone Signal Transduction Pathways,” S. Song, J. Chang, C. Ma, and Y.-W. Tan,Front. Plant Sci., 02 (2017). “Lipid Regulated Intramolecular Conformational Dynamics of SNARE-Protein Ykt6,” Y. Dai, M. Seeger, J. Weng, S. Song, W. Wang, and Y.-W. Tan,Scientific Reports 6, 30282 (2016). “Temperature-feedback upconversion nanocomposite for accurate photothermal therapy at facile temperature,” X. Zhu, W. Feng, J. Chang, Y.-W. Tan, J. Li, M. Chen, Y. Sun, and F. Li,Nature Communications7, 10437 (2016). “Septin ring assembly is regulated by Spt20, a structural subunit of the SAGA complex,” B. Lei, N. Zhou, Y. Guo, W. Zhao, Y.-W. Tan, Y. Yu, and H. Lu*,J Cell Sci127, 4024 (2014). “Surface-Modified Silicon Nanoparticles with Ultrabright Photoluminescence and Single-Exponential Decay for Nanoscale Fluorescence Lifetime Imaging of Temperature,” Qi Li, Yao He, Jian Chang, Lei Wang, Hongzheng Chen, Yan-Wen Tan, Haiyu Wang and Zhengzhong Shao*,J. Am. Chem. Soc., 135(40), 14924 (2013). “Confocal Single-Molecule FRET for Protein Conformational Dynamics,” Yan-Wen Tan, Jeffery A. Hanson, Jhih-Wei Chu, and Haw Yang,Protein Dynamics: Methods and Protocols;Methods in Molecular Biolog, 1084, (2013). "Seeing the Forest for the Trees: Fluorescence Studies of Single Enzymes in the Context of Ensemble Experiments," Y.-W. Tan and H. Yang,Phys. Chem. Chem. Phys.,13, 1709 (2011). “Direct Mg2+ binding activates Adenylate Kinase from Escherichia coli,” Y.-W. Tan, J. A. Hanson, H. Yang, J. Biol. Chem.284, 3306 (2009) “Unraveling the Dynamics Bridging Protein Structure and Function One Molecule at a Time,” J. A. Hanson, Y.-W. Tan, and H. Yang, inSingle Particle Tracking and Single Molecule Energy Transfer: Applications in the Bio and Nano Sciencesedited by Christoph Br?uchle, Don Lamb and Jens Michaelis, Wiley-VCH. “Spin Texture and Magnetoroton Excitations at =1/3,” J. G. Groshaus, I. Dujovne, Y. Gallais, C. F. Hirjibehedin, A. Pinczuk, Y.-W. Tan, H. L. Stormer, B. S. Dennis, L. N. Pfeiffer, and K. W. West,Phys. Rev. Lett.100, 046804 (2008) “Measurement of Scattering Rate and Minimum Conductivity in Graphene,” Y.-W. Tan, Y. Zhang, K. Bolotin, Y. Zhao, S. Adam, E. H. Hwang, S. Das Sarma, H. L. Stormer, and P. Kim,Phys. Rev. Lett.99, 246803 (2007) “Temperature Dependant Electron Transport in Graphene,” Y.-W. Tan, Y. Zhang, H. L. Stormer, and P. Kim,Eur. Phys. J.148, 15 (2007) “High Frequency Magneto Oscillations in GaAs/AlGaAs Quantum Wells,” Y.-W. Tan, H. L. Stormer, L. N. Pfeiffer, K. W. Baldwin, and K. W. West,Phys. Rev. Lett.98, 036804 (2007). “Spin susceptibility and effective mass of a 2D electron system in GaAs heterostructures towards the weak interacting regime,” Y.-W. Tan, J. Zhu, H.L. Stormer, L.N. Pfeiffer, K.W. Baldwin and K.W. West,Physica E,34, 260-263, (2006) “Landau-Level Splitting in Graphene in High Magnetic Fields,” Y. Zhang, Z. Jiang, J. P. Small, M. S. Purewal, Y.-W. Tan, M. Fazlollahi, J. D. Chudow, J. A. Jaszczak, H. L. Stormer, and P. Kim,Phys. Rev. Lett.96, 136806 (2006) “Spin susceptibility of a two-dimensional electron system in GaAs towards the weak interaction region,” Y.-W. Tan, J. Zhu, H. L. Stormer, L. N. Pfeiffer, K. W. Baldwin, and K. W. West,Phys. Rev. B73, 045334 (2006) “Experimental Observation of Quantum Hall Effect and Berry’s Phase in Graphene,” Y. Zhang, Y.-W. Tan, H. L. Stormer, P. Kim,Nature438, 201 (2005) “Measurements of the Density-Dependent Many-Body Electron Mass in Two Dimensional GaAs/AlGaAs Heterostructures,” Y.-W. Tan, J. Zhu, H. L. Stormer, L. N. Pfeiffer, K. W. Baldwin, and K. W. West,Phys. Rev. Lett.94, 016405 (2005)