黄则度 - 复旦大学

个人简介

2003.9-2007.6 浙江大学化学系本科，获得学士学位 2007.9-2012.8 加拿大阿尔伯塔大学化学系研究生，获得博士学位 2012.11-2016.10 美国伊利诺伊大学香槟分校，博士后 2016.11-2022.11 复旦大学化学系，青年研究员 2022.12起复旦大学化学系，副教授

研究领域

新颖酶催化和生物催化反应的发现与应用手性药物与手性技术的研究合成生物学

近期论文

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Zhu, K.; Jiang, M.; Ye, B.; Zhang, G.; Li, W.; Tang, P.; Huang, Z.;* Chen, F.* A Unified Strategy to Prostaglandins: Chemoenzymatic Total Synthesis of Cloprostenol, Bimatoprost, PGF2, Fluprostenol, and Travoprost Guided by Biocatalytic Retrosynthesis. Chem. Sci. 2021, 12, 10362-10370. Zhang, Y.; Liu, M.; Yang, Z.; Lin, J.;* Huang, Z.;* Chen, F.* Batch and Continuous Flow Asymmetric Synthesis of Anabolic-Androgenic Steroids via a Single-Cell Biocatalytic Δ1-Dehydrogenation and C17-Carbonyl Reduction Cascade. Green Chem. 2023, 25, 3223-3235. Liu, J.; Wu, X.; Li, Z.; Huang, Z.;* Chen, F.* Engineered Monoamine Oxidase-Catalyzed Deracemization of Sterically Hindered Acylaminomethyl-tetrahydroisoquinoline: Asymmetric Synthesis of (R)‑(−)-Praziquantel and Its Analogues. ACS Sustain. Chem. Eng. 2023, doi.org/10.1021/acssuschemeng.3c00985. Li, Y.; Yue, X.; Li, Z.; Huang, Z.;* Chen, F.* Asymmetric Synthesis of Sterically Hindered 1Substituted Tetrahydro-β-carbolines Enabled by Imine Reductase: Enzyme Discovery, Protein Engineering, and Reaction Development. Org. Lett. 2023, 25, 1285-1289. Yue, X.; Li, Y.; Liu, M.; Sang, D.; Huang, Z.;* Chen, F.* Biocatalytic Dynamic Reductive Kinetic Resolution of Aryl -Chloro -Keto Esters: Divergent, Stereocontrolled Synthesis of Diltiazem, Clentiazem, and Siratiazem. Chem. Commun. 2022, 58, 9010-9013. Li, Z.; Wang, Z.; Wang, Y.; Wu, X.; Lu, H.; Huang, Z.;* Chen, F.* Substituent Position-Controlled Stereoselectivity in Enzymatic Reduction of Diaryl- and Aryl(heteroaryl)methanones. Adv. Synth. Catal. 2019, 361, 1859-1865. Wu, X.; Huang, Z.;* Wang, Z.; Li, Z.; Wang, J.; Lin, J.;* Chen, F.* Asymmetric Synthesis of a Key Dextromethorphan Intermediate and Its Analogues Enabled by a New Cyclohexylamine Oxidase: Enzyme Discovery, Reaction Development, and Mechanistic Insight. J. Org. Chem. 2020, 85, 5598-5614. Wu, X.; Li, Z.; Lin, J.;* Huang, Z.;* Chen, F.* Engineered Cyclohexylamine Oxidase with Improved Activity and Stereoselectivity for Asymmetric Synthesis of a Bulky Dextromethorphan Precursor and Its Analogues. ChemCatChem 2022, 14, doi.org/10.1002/cctc.202101970. Li, Z.; Yang, H.; Liu, J.; Huang, Z.;* Chen, F.* Application of Ketoreductase in Asymmetric Synthesis of Pharmaceuticals and Bioactive Molecules: An Update (2018-2020). Chem. Rec. 2021, 21, 1611-1630. Hu, C.; Ye, B.; Huang, Z.;* Chen, F.* Development Of an Engineered Ketoreductase with Improved Activity, Stereoselectivity and Relieved Substrate Inhibition for Enantioselective Synthesis of a Key (R)--Lipoic Acid Precursor. Mol. Catal. 2022, 522, 112208.