陈勤 - 复旦大学

个人简介

学习工作经历 1999.9-2003.7 浙江师范大学生物系本科，获得理学学士学位 2003.9-2008.7 中科院上海药物研究所硕博连读，获得理学博士学位 2009.4-2011.12 美国纽约州立大学石溪分校，博士后 2012.3-2016.5 上海交通大学医学院，副研究员 2016.6-2017.8 上海科技大学，副研究员 2017.9起复旦大学化学系，青年研究员获奖情况 2014年上海交通大学医学院“九龙医学优秀青年人才奖

研究领域

肿瘤、糖尿病和心血管等重大疾病的新药研发化学小分子与生物大分子相互作用的研究

近期论文

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Bao Cheng, Guirong Zhu, Linghua Meng, Guolin Wu, Qin Chen,* Shengming Ma*. Identification and optimization of biphenyl derivatives as novel tubulin inhibitors targeting colchicine-binding site overcoming multidrug resistance Eur. J. Med. Chem. 2022, 228, 113930. Anni Qin, Hui Qian, Qin Chen,* Shengming Ma*. Palladium-Catalyzed Coupling of Propargylic Alcoholswith Boronic Acids underAmbient Conditions Chin. J. Chem. 2020, 38, 372-382 Helin Lu, Guirong Zhu, Tiange Tang, Zhuang Ma, Qin Chen,* Zhilong Chen*. Anticancer Molecule Discovery via C2-Substituent Promoted Oxidative Coupling of Indole and Enolate iScience, 2019, 22, 214-228 Lei Ke, Guirong Zhu, Hui Qian, Guangya Xiang, Qin Chen,* Zhilong Chen*. Catalytic Selective Oxidative Coupling of Secondary N?Alkylanilines: An Approach to Azoxyarene Org. Lett. 2019, 21, 4008?4013 Anni Qin, Guirong Zhu, Qin Chen,* Hui Qian,* Shengming Ma*. Palladium‐Catalyzed Desulfitative Cross‐Coupling Reaction of Sodium Sulfinates with Propargylic Carbonates Adv. Synth. Catal. 2019, 361, 4656-4660 Guolin Wu, Bao Cheng, Hui Qian, Shengming Ma, Qin Chen. Identification of HSP90 as a direct target of artemisinin for its anti-inflammatory activity via quantitative chemical proteomics. Org. Biomol. Chem., 2019, 17, 6854-6859 Yuan Yao, Guirong Zhu, Qin Chen,* Hui Qian,* Shengming Ma* Efficient synthesis of tetrasubstituted 2,3-allenoates and preliminary studies on bioactivities. Org. Chem. Front., 2019, 6, 304-308 Xinyu Duan, Pengbin Li, Guirong Zhu, Chunling Fu, Qin Chen,* Xin Huang,* Shengming Ma*. Pd/Gorlos-Phos-catalyzed cross-coupling between two different aryl chlorides in the presence of B2Pin2 and cytotoxicity studies of the products. Org. Chem. Front. 2018, 5,3319-3323 Jiaxin Liu, Longhai Li, Liuzhu Yu, Lisha Tang, Qin Chen,* Min Shi* Visible-Light-Induced Trifluoromethylation of Isonitrile-Substituted Indole Derivatives: Access to 1-(Trifluoromethyl)-4,9-dihydro-3H-pyrido[3,4-b]indole and beta-Carboline Derivatives. Adv. Synth. Catal. 2018, 360:2959 Qin Chen,* Rong Deng, Xian Zhao, Haihua Yuan, Hailong Zhang, Jinzhuo Dou, Ran Chen, Hui Jin, Yanli Wang, Jian Huang, Jianxiu Yu* Sumoylation of EphB1 Suppresses Neuroblastoma Tumorigenesis via Inhibiting PKCγ Activation. Cell Physiol Biochem. 2018, 45(6):2283-2292