蔡泉 - 复旦大学

个人简介

学习工作经历 2022.12-今复旦大学化学系，教授 2017.6-2022.11 复旦大学化学系，青年研究员 2016.4-2017.6 美国哈佛大学医学院，Dana-Farber癌症研究所，博士后(合作导师：Nathanael Gray 教授) 2013.8-2016.3 美国Rice大学（Houston, TX），博士后(合作导师：K. C. Nicolaou 教授) 2012.9-2013.7 美国Scripps研究所（La Jolla, CA），博士后(合作导师：K. C. Nicolaou 教授) 2007.9-2012.7 中国科学院上海有机化学研究所，博士(导师：游书力研究员) 2003.9-2007.7 华东理工大学药学院，本科获奖情况 2022年国家自然科学基金委优秀青年基金 2020年 Thieme Chemistry Journal Award 2014年上海市研究生优秀成果（学位论文） 2013年中国科学院百篇优秀博士学位论文奖 2012年中国科学院院长特别奖 2012年中国科学院优秀毕业生

研究领域

不对称催化反应天然产物全合成手性药物合成

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Meng-Meng Xu,† Pei-Pei Xie,† Jun-Xiong He, Yu-Zhen Zhang, Chao Zheng*, Quan Cai*. Enantioselective Cross-[4+2]-Cycloaddition/Decarboxylation of 2Pyrones by Cooperative Catalysis of the Pd(0)/NHC Complex and Chiral Phosphoric Acid. J. Am. Chem. Soc. 2024, 146, 6936−6946. Xu-Ge Si, Shi-Xiong Feng, Zhuo-Yan Wang, Xiaoyu Chen, Meng-Meng Xu, Yu-Zhen Zhang, Jun-Xiong He, Limin Yang*, Quan Cai*. Enantioselective Synthesis of cis-Decalins by Merging the Birch Reduction and Inverse-Electron-Demand Diels–Alder Reaction. Angew. Chem. Int. Ed.2023, e202303876. Yu-Zhen Zhang, Meng-Meng Xu, Xu-Ge Si, Jun-Li Hou, Quan Cai*. Enantioselective Synthesis of Inherently Chiral Calix[4]arenes via Palladium-Catalyzed Asymmetric Intramolecular C-H Arylations. J. Am. Chem. Soc. 2022, 144, 22858−22864. Yang Lu, Meng-Meng Xu, Zhi-Mao Zhang, Jun-Liang Zhang, Quan Cai*. Catalytic Asymmetric Inverse-Electron-Demand Diels–Alder Reactions of 2-Pyrones with Indenes: Total Syntheses of Cephanolides A and B. Angew. Chem. Int. Ed. 2021, 60, 26610–26615. Meng-Meng Xu,† Limin Yang,† Kui Tan, Xiangyang Chen, Qi-Tao, Lu, K. N. Houk*, Quan Cai*. An enantioselective ambimodal cross-Diels–Alder reaction and applications in synthesis. Nat. Catal.2021, 4, 892–900. Meng-Meng Xu, Xin-Yu You, Yu-Zheng Zhang, Yang Lu, Kui Tan, Limin Yang*, Quan Cai*. Enantioselective Synthesis of Axially Chiral Biaryls by Diels−Alder/Retro-Diels−Alder Reaction of 2-Pyrones with Alkynes. J. Am. Chem. Soc. 2021, 143, 8993–9001. Xu-Ge Si,† Zhi-Mao Zhang,† Cheng-Gong Zheng, Zhan-Ting Li, Quan Cai*. Enantioselective Synthesis of cis-Decalin Derivatives by the Inverse-Electron-Demand Diels–Alder Reaction of 2-Pyrones. Angew. Chem. Int. Ed.2020, 59, 18412–18417. Xiao-Wei Liang,† Yunlong Zhao,† Xuge Si, Meng-Meng Xu, Jia-Hao Tan, Zhi-Mao Zhang, Cheng-Gong Zheng, Chao Zheng, Quan Cai*. Enantioselective Synthesis of Arene cis-Dihydrodiols from 2-Pyrones. Angew. Chem. Int. Ed. 2019, 58, 14562–14567. K. C. Nicolaou*, Pengxi Chen,† Shugao Zhu,† Quan Cai,† Rohan D. Erande, Ruofan Li, Hongbao Sun, Kiran Kumar Pulukuri, Stephen Rigol, Monette Aujay, Joseph Sandoval, Julia Gavrilyuk. Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues Thereof. Discovery of Simpler Designed and Potent Trioxacarcin Analogues. J. Am. Chem. Soc. 2017, 139, 15467. K. C. Nicolaou*, Quan Cai, Hongbao Sun, Bo Qin, Shugao Zhu. Total Synthesis of Trioxacarcins DC-45-A1, A, D, C and C7ˊˊ-epi-C and Full Structural Assignment of Trioxacarcin C. J. Am. Chem. Soc. 2016, 138, 3118. K. C. Nicolaou*, Quan Cai, Bo Qin, Mette T. Peterson, Remi J. T. Mikkelsen, Philipp Heretsch. Total Synthesis of Trioxacarcin DC-45-A2. Angew. Chem. Int. Ed.2015, 54, 3074. Quan Cai, Chao Zheng, Jun-Wei Zhang, Shu-Li You*. Enantioselective Michael/Mannich Polycyclization Cascade of Indolyl Enones Catalyzed by Quinine-Derived Primary Amines. Angew. Chem. Int. Ed.2011, 50, 8665. Quan Cai, Chao Zheng, Shu-Li You*. Enantioselective Intramolecular Aza-Michael Addition of Indoles Catalyzed by Chiral Phosphoric Acid. Angew. Chem. Int. Ed.2010, 49, 8666. Quan Cai, Zhuo-An Zhao, Shu-Li You*. Asymmetric Construction of Polycyclic Indoles through Olefin Cross-Metathesis/ Intramolecular Friedel-Crafts Alkylation under Sequential Catalysis. Angew. Chem. Int. Ed.2009, 48, 7428.