马炯 - 复旦大学 - 信息科学与工程学院

个人简介

学习与工作经历 2015年至今，复旦大学，光科学与工程系，青年研究员 2012-2015年，美国Temple University，生物系，研究助理教授 2008-2012年，美国Bowling Green State University，生物系及光化学中心，博士后 2003-2008年，复旦大学，物理系，光学博士（硕博连读） 2007-2008年，挪威University of Oslo，生理系，访问学者 2007年6-9月，南非Rhodes University，化学系，访问学者 1999-2003年，复旦大学，物理系，理学学士

研究领域

光学技术在生物医学上的应用与发展： 1、新型实时三维高速超分辨显微镜的开发及相关的生物应用 2、单点斜入射快速超分辨显微技术（SPEED Microscopy）在各类对称生物系统内的应用 3、荧光的时间分辨光谱在生物医学研究中的应用 4、细胞核孔复合物（NPC）对基因相关物质运输的选择性机制 5、腺相关病毒（AAV）在基因治疗中的相关机理及应用 6、可穿戴光动力治疗（PDT）

近期论文

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Wang M., Tang F., Pan X., Yao L., Wang X., Jing Y., Ma J., Wang G. and Mi L. (2017) “Rapid diagnosis and intraoperative margin assessment of human lung cancer with fluorescence lifetime imaging microscopy” BBA clinical 8:7-13. Ma J., Kelich J., Junod S and Yang W. (2017) “Super-resolution mapping of scaffold nucleoporins in the nuclear pore complex” J Cell Sci 130(7):1299-1306. Wang M., Long F., Tang F., Jing Y., Wang X., Yao L, Ma J., Fei Y., Chen L., Wang G. and Mi L. (2017) “Autofluorescence Imaging and Spectroscopy of Human Lung Cancer” Applied Sciences 7(1):32. Xie J., Pan X., Wang M., Yao L., Liang X., Ma J., Fei Y., Wang P. and Mi L. (2016) “Targeting and Photodynamic Killing of Cancer Cell by Nitrogen-Doped Titanium Dioxide Coupled with Folic Acid.” Nanomaterials 6(6), 113 Xie J., Pan X., Wang M., Ma J., Fei Y., Wang PN. and Mi L. (2016) “The role of surface modification for TiO2 nanoparticles in cancer cells.” Colloids Surf B Biointerfaces. 143:148-55. Ma J., Kelich J. and Yang W. (2016) “SPEED microscopy and its application in nucleocytoplasmic transport” In: Shackleton S., Collas P and Schirmer E (ed) Methods in Molecular Biology on the Nuclear Envelope. Spinger. (Accepted) Ma J., Goryaynov A. and Yang W. (2016) “Super-resolution 3D tomography of interactions and competition in the nuclear pore complex” Nature structure and molecular biology, 23, 239–247. Kelich J., Ma J., Dong B., Wang Q., Chin, M,. Magura C., Xiao W. and Yang W. (2015) “Super-resolution Imaging of Nuclear Import of Adeno-Associated Virus in Live Cells.” Mol. Ther. 2, Article number: 15047 (2015) doi:10.1038/mtm.2015.47. Schnell S., Ma J. and Yang W. (2014) “Three-Dimensional Mapping of mRNA Export through the Nuclear Pore Complex” Genes, 5, 1032-1049. Ma J., Liu Z., Michelotti N., Veerapaneni R., Pitchiaya S., Walter N. and Yang W. (2013) “High-resolution three-dimensional mapping of mRNA export through the nuclear pore” Nature Communication, 4:2414 doi:10.1038/ncomms3414. Ma J., Goryaynov A., Sarma A. and Yang W. (2012) “Self-Regulated Viscous Channel in the Nuclear Pore Complex” Proc. Natl. Acad. Sci. USA, 109 (19) 7326-7331. Goryaynov A., Ma J., and Yang W. (2012) “Single-Molecule Studies of Nucleocytoplasmic Transport: from One Dimension to Three Dimensions” Integrative Biology, 4(1), 10-21. (Cover story) Ma J. and Yang W. (2010) “Three-dimensional distribution of transient interactions in the nuclear pore complex obtained from single-molecule snapshots” Proc. Natl. Acad. Sci. USA, 107, 7305-7310. Goryaynov A., Sarma A., Ma J., and Yang W. (2010) “Single-Molecule Imaging of Nuclear Transport”, J. Vis. Exp. (http://www.jove.com/index/Details.stp?ID=2040). Lu SJ, Chen JY, Zhang Y, Ma J, Wang PN, Peng Q. (2008) “Fluorescence detection of protoporphyrin IX in living cells: a comparative study on single- and two-photon excitation”. Journal of Biomedical Optics 13(2):024014. Ma J, Chen JY, Idowu M and Nyokong T. (2008) “Generation of singlet oxygen via the composites of water-soluble thiol-capped CdTe quantum dots – sulfonated aluminium phthalocyanines”. Journal of Physical Chemistry B 112 (15): 4465-4469. Zhang Y, Mi L, Wang PN, Ma J, Chen JY. (2008) “pH-dependent aggregation and photoluminescence behavior of thiol-capped CdTe quantum dots in aqueous solutions”. Journal of Luminescence 128(12): 1948-1951. Ma J, Chen JY, Yu Zhang, Wang PN, Guo J, Wang CC, Yang WL and Cheung NH. (2007) “Photochemical Instability of Thiol-Capped CdTe Quantum Dots in Aqueous Solution and Living Cells: Process and Mechanism”. Journal of Physical Chemistry B 111 (41): 12012-12016. Yang Y, Ma J. Wang, YH, Yin, CH. (2007) “Studies on the compounds of 5-aminolevulinic acid and phospholipid”. Chinese Pharmaceutical Journal 42(1): 36-39. Ma J, Chen JY, Guo J, Wang CC, Yang WL, Cheung NH and Wang PN. (2006) “Improvement of the photostability of thiol-capped CdTe quantum dots in aqueous solutions and in living cells by surface treatment”. Nanotechnology 17 (23): 5875-5881. Ma J, Chen JY, Guo J, Wang CC, Yang WL, Xu L and Wang PN. (2006) “Photostability of thiol-capped CdTe quantum dots in living cells: the effect of photo-oxidation”. Nanotechnology 17 (9): 2083-2089. [Remark: this paper was selected as the highlight paper introduced in NanotechWeb 12 April 2006, and evaluated as one of most download papers in Nanotechnology Xue FL, Lu DR, Guo J, Ma J and Su Y. (2006) “Intracellular Delivery of CdTe Quantum Dots Conjugated with Polypeptide Tat”. Journal of Fudan University (Natural Science) 45(3): 298-302. Ma J, Chen JY, Guo J, Wang CC, Xu L, Wang, PN. (2005) “Photo-stability of water-soluble quantum dots in living cells”. Chinese Optics Letters 3: S208-S209. Ma J, Cen Y and Chen JY. (2005) “An in vitro study on transition from NO-hemoglobin to methemoglobin: Oxygen effect”. Chinese Journal of Chemistry 23 (5): 637-639. Cen Y, Zhang R, Yao WH, Ma J and Chen JY. (2005) “Raman spectral study of nitrosyhemoglobin and several other hemoglobins”. Spectroscopy and Spectral Analysis 25 (3): 405-408. Cen Y, Ma J, Zhu RY, Lu JJ, Qian SX and Chen JY. (2004) “Femtosecond time-resolved absorption of oxyhaemoglobin photolysis in living erythrocytes”. Chinese Physics Letters 21 (8): 1636-1639.

学术兼职

中国光学学会第二届生物医学光子学专业委员会青年委员中国生物医学工程协会生物医学光子学分会会员美国生物物理学会会员上海市科学技术专家库成员