Zhang, Wei - University of Massachusetts-Boston

个人简介

1993 - 1995 Postdoctoral Fellow (Advisor Prof. Paul Dowd), Department of Chemistry, University of Pittsburgh, PA 1989 - 1993 PhD in Organic Chemistry (Advisor Prof. Paul Dowd), Department of Chemistry, University of Pittsburgh, PA 1978 - 1982 BS in Chemistry (Analytical), Nanjing University, China POSITIONS 2013 - Professor and Director of the Center for Green Chemistry, Department of Chemistry, University of Massachusetts Boston, MA 2008 - 2013 Associate Professor and Director of the Center for Green Chemistry, University of Massachusetts Boston, MA 2004 - 2008 Director of Discovery Chemistry, Fluorous Technologies, Inc. Pittsburgh, PA 2001 - 2004 Senior Scientist/Head of Combinatorial Chemistry, Fluorous Technologies, Inc. Pittsburgh, PA 1995 - 2001 Research Chemist/Section Chemist, DuPont Agricultural Products, Newark, DE 1993 - 1995 Research Assistant Professor, Department of Chemistry, University of Pittsburgh, PA 1989 - 1993 Research Assistant, Department of Chemistry, University of Pittsburgh, PA 1982 - 1989 Analytical Lab Group Leader, Jiangsu Pesticide Research Institute, Nanjing, China

研究领域

Organic Chemistry To develop new synthetic methodologies based on fluorous synthesis, multicomponent reactions, free radical reactions, and asymmetric organocatalysis. Green Chemistry To develop new synthetic and separation processes with good atom economy, energy efficiency, product separation and chemical recycling capability, and minimal waste disposal. Medicinal Chemistry To design and synthesize drug-like molecules and natural product analogs for biological screenings at our collabrator's labs Fluorous Technology To develop new fluorous technologies and their applications in organic, separation, biological, and material sciences. Our group is a leader in the application of fluorous techniques for solution-phase parallel and combinatorial synthesis of chemical libraries. Students in this group will learn advanced synthetic and analytical skills related to HPLC, LC-MS, NMR, microwave reactor, solid-phase extraction, and chiral separations.

近期论文

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Zhang, X.; Liu, L.; Murray, S. A.; Qiu, W.; Ma, X.; Evans, J.; Jasinski, J. P.; Zhang, W. "Pseudo Five-Component Reaction for Diastereoselective Synthesis of Symmetric Bispiro[oxindole-pyrrolidine]s", MS submitted Taoo, Z.-K.; Li, C.-K.; Li, J-a. Shoberu, A.; Zhang, W.; Zou, J.-P. "Copper-Catalyzed Vicinal Cyano-, Thiocyano-, and Chlorophosphorylation of Alkynes: A Phosphinoyl Radical-Initiated Approach for Difunctionalized Alkenes" Org. Lett.2021, under revision. Muthengi, A.; Wimalasena, V. K.; Yosief, H. O.; Bikowitz, M. J.; Li, D.; Gaieb, Z.; Dhawan, G.; Liu, S.; Erickson, J.; Sch�nbrunn, E.; Amaro, R. E.; Qi, J.; Zhang, W. "Development of Dimethylisoxazole-attached Imidazo[1,2-a]pyridines as Potent and Selective CBP/P300 Inhibitors" J. Med. Chem. article asap. Ma, X.; Qiu, W.; Liu, L.; Zhang, X.; Zhang, Q.; Awad, J.; Evans, J.; Zhang, W. "Synthesis of Tetrahydropyrrolothiazoles through One-pot and 4-Component N,S-acetalation and Decarboxylative [3+2] Cycloaddition" Green Syn. Catal.2021, 2, 74-77. Yang, G.; Liu, Y.; Wang, L.; Zhang, Y.; Ma, X.; Zahng, W. "Diastereoselective Synthesis of Hexahydropyrrolo[2,1-a]isoquinolines by [3+2] Cycloaddition and Cyclative Heck Alkyne Hydroarylation" Tetrahedron Lett. 2021, 62, 152859. Zhao, H.; Lu, C.; Herbert, S.; Zhang, W.; Shen, Q. "Difluoromethylation of Alkyl Bromides and Iodides with TMSCF2H under Mild Conditions" J. Org. Chem.2021, 86, 2854-2865. Zhang, X.; Ma, X.; Qiu, W.; Awad, J. Evans, J.; Zhang, W. "One-pot Mannich, Aza-Wittig and Dehydrofluorinative Aromatization Reactions for Direct Synthesis of 2,3-Disubstituted 4-Aminoquinolines" Adv. Syn. Catal.2020, 362, 5513-5517. Zhou, D.; Hayashi, T.; Jean, M.; Kong, W.; Fiches, G.; Biseas, A.; Liu, S.; Yosief, H. O.; Zhang, X.; Bradner, J. Qi, J.; Zhang, W.; Santoso, N.; Zhu, J. "Inhibition of Polo-like kinase 1 (PLK1) facilitates the elimination of HIV-1 viral reservoirs in CD4+ T cells" Sci. Adv. 2020, 6, eaba1941. Ma, X.; Meng, S.; Zhang, X.; Zhang, Q.; Yan, S.; Zhang, Y.; Zhang, W. "Synthesis of Pyrrolidinedione-Fused Hexahydropyrrolo[2,1-A]Isoquinolines via Three-Component [3+2] Cycloaddition Followed by One-Pot N-Allylation and Intramolecular Heck Reactions" Beilstein J. Org. Chem.2020,16, 1225-1233. Zhao, H.; Herbert, S.; Kinzel, T.; Zhang, W.; Shen, Q. "Two Ligands Transfer from Ag to Pd: En Route to (SIPr)Pd(CF2H)(X) and its Application in One-pot C-H Borylation/Difluoromethylation" J. Org. Chem.2020, 85, 3596-3604. Ma, X.; Zhang, X.; Awad, J. M.; Xie, G.; Qiu, W.; Muriph, R.E.; Zhang, W. "Sequential Decarboxylative [3+2] Cycloaddition and aza-Wittig Reactions for Diastereoselective Synthesis of Tetrahydro-pyrroloquinazolines and Tetrahydro-pyrrolobenzodiazepines" Tetrahedron Lett. 2020, 61, 151392. Zhang, T.; Pan, J.; Duan, J.; Wu, J. Zhang, W.; Wu, F. "Nickel-Catalyzed Radical Bifunctionalization of Alkenes with 2,2-Difluoro-2-iodo-1-phenylethanone for Iododifluoromethyl Ketones" ChemCatChem 2019, 11, 5778-5782. Ma, X.; Zhang, X.; Xie, G.; Awad, J. M.; Zhang, W. "One-pot Synthesis of Tetrahydroepimino-benzo[b]azocine through [3 + 2] Cycloaddition and Aza-Wittig Reactions" Tetrahedron Lett. 2019, 60, 151127. Timm, N.; Han, Y.; Liu; S.; Yosief, H. O.; Garcia, H. D.; Bei, Y.; Klironomos, F.; MacArthur, I. C.; Szymansky, A.; Bardinet, V.; Dohna, C.; K�nkele, A.; Rolff, J.; Hundsd�rfer, P.; Lissat, A.; Seifert, G.; Eggert, A.; Schulte, J. H.; Zhang, W.; Henssen, A. G. "Small-Molecule Dual PLK1 and BRD4 Inhibitors Are Highly Active Against Preclinical Models of MYC/N-Driven Pediatric Tumors" Transl. Oncol.2019, 13, 221-232. Ma, X.; Zhang, X.; Awad, J. M.; Xie, G.; Qiu, W.; Zhang, W. "One-pot Synthesis of Tetrahydro-pyrrolobenzodiazepines and Tetrahydro-pyrrolobenzodiazepinons Through Sequencial 1,3-Dipolar Cycloaddition/N-Alkylation (N-Acylation)/Staudinger/Aza-Wittig Reactions" Green Chem. 2019,21, 4489-4494. Jia, L.; Gui, B.; Takai, T.; Feng, C.; Bai, X.; Liu, S.; Zhang, X.; Zhang, W. Kibel, K. "Selective Targeting of PARP2 Inhibits Androgen Receptor Signaling and Prostate Cancer Growth Through Disruption of FOXA1 Function" Proc. Natl. Acad. Sci.2019, 116, 14573-14582. Kong, W.; Hayashi, T.; Fiche, G.; Xu, Q.; Li, M. Z.; Que, J.; Liu, S.; Zhang, W.; Qi, J.; Santoso, N.; Elledge, S.; Zhu, J. "Diversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interactions" Genomics Proteomics Bioinformatics 2019, 17, 319-331. Muthengi, A. Erickson, J.; Muriph, R. E.; Zhang, W. "[3+2] Cycloaddition and Cascade Radical Reaction for the Synthesis of Trifluoromethylated Tetrahydrobenzodiazepin-3-ones" J. Org. Chem. 2019, 83, 5927�5935. Zhang, X.; Qiu, W.; Evans, J.; Kaur, M.; Jasinski, J. P.; Zhang, W. "Double 1,3-Dipolar Cycloadditions of Two Nonstabilized Azomethine Ylides for Polycyclic Pyrrolidines" Org. Lett. 2019,21, 2146-2179. Ma, X.; Zhang, X.; Qiu, W.; Zhang, W.; Wan, B.; Evans, J. Zhang, W. "One-pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3+2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-free Click Reactions" Molecules 2019, 24, 601.