Torok, Marianna - University of Massachusetts-Boston

个人简介

Education: Postdoctoral Research, Massachusetts Institute of Technology, Cambridge, MA Postdoctoral Research, University of Southern California, Los Angeles, CA Ph.D., University of Szeged, Faculty of Medicine, Szeged, Hungary B.S/MS., University of Szeged, Faculty of Science, Szeged, Hungary

研究领域

Physical Biochemistry, Medicinal Chemistry, Protein Structure and Dynamics, Biological Applications of Electron Paramagnetic Resonance Spectroscopy, Free Radicals, Protein Misfolding and Amyloidogenesis, Alzheimer's Disease, Amyloid-beta Peptide, Peptide Synthesis, Biochemical Education.

近期论文

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Bag S, Tulsan R, Sood A, Cho H, Redjeb H, Zhou W, LeVine H III, Török B, Török M. Sulfonamides as Multi-functional Agents for Alzheimer’s Disease. Bioorganic & Medicinal Chemistry Letters, 25: 626-630, 2015. Schäfer C, Mhadgut SC, Kugyela N, Török M, Török B, Proline Induced Enantioselective Heterogeneous Catalytic Hydrogenation of Isophorone on Basic Polymer Supported Pd Catalysts. Catalysis Science & Technology 2015, Advance article DOI: 10.1039/C4CY00954A Ghosh S, Schifone C, Foster M, Török B, LeVine III H, Török M. Hydrazines as Potential Anti-amyloidogenic Agents. FASEB Journal, 27: 996.6, 2013 (Meeting Abstract). Bag S, Ghosh S, Tulsan R, Sood A, Zhou W, Schifone C, Foster M, LeVine H III, Török B, Török M. Design, Synthesis and Biological Activity of Multifunctional a,b-Unsaturated Carbonyl Scaffolds for Alzheimer’s Disease. Bioorganic & Medicinal Chemistry Letters, 23: 2614-2618, 2013. Török B, Sood A, Bag S, Tulsan R, Ghosh S, Borkin D, Kennedy AR, Melanson M, Madden R, Zhou W, LeVine H III, Török M. Diaryl Hydrazones as Multifunctional Inhibitors of Amyloid Self-Assembly. Biochemistry, 52: 1137-1148, 2013. Melanson M, Sood A, Török F, Török M Introduction to Spin Label Electron Paramagnetic Resonance Spectroscopy of Proteins. Biochemistry and Molecular Biology Education, 41: 156-162, 2013. Török B, Bag S, Sarkar M, Dasgupta S,Török M. Structural Features of Small Molecule Amyloid-Beta Self-Assembly Inhibitors. Current Bioactive Compounds, 9: 37-63, 2013. Bag S, Tulsan A, Sood A, Datta S, Török M. Pharmacophore Modeling, Virtual and In Vitro Screening for Acetylcholinesterase Inhibitors and their Effects on Amyloid-ß Self-assembly. Current Computer-Aided Drug Design, 9: 2-14, 2013. Török B, Sood A, Bag S, Kulkarni A, Borkin D, Lawler E, Dasgupta S, Landge S, Abid M, Zhou W, Foster M, LeVine III H, Török M. Structure–Activity Relationships of Organofluorine Inhibitors of ß-Amyloid Self-Assembly. ChemMedChem 7: 910-919, 2012. Török B, Kulkarni A, DeSousa R, Satuluri K, Török M, Prakash GSK. Synthesis and application of polystyrene nanospheres supported platinum catalysts in enantioselective hydrogenations. Catalysis Letters 141:1435-1441, 2011. Sood A, Abid M, Sauer C, Hailemichael S, Foster M, Török B, Török M . Disassembly of preformed amyloid beta fibrils by small organofluorine molecules. Biorganic & Medicinal Chemistry Letters 21: 2044-2047, 2011. Borkin D, Morzhina E, Datta S, Rudnitskaya A, Sood A, ,Török M , Török B. Heteropoly Acid-Catalyzed Microwave-Assisted Three-Component Aza-Diels-Alder Cyclizations: Diastereoselective Synthesis of Potential Drug Candidates for Alzheimer’s Disease. Organic and Biomolecular Chemistry, 9: 1394-1401, 2011 . Datta S, Sood A, Török M . Steps Toward Green Peptide Synthesis. Current Organic Synthesis, 8: 262-280, 2011 . Rudnitskaya A, Török B, Török M . Molecular Docking of Enzyme Inhibitors, a Computational Tool for Structure-Based Drug Design. Biochemical and Molecular Biology Education, 38: 261–265, 2010. Sood A, Abid M,Hailemichael S, Foster M, Török B, Török M . Effect of Chirality of Small Molecule Organofluorine Inhibitors of Amyloid Self-Assembly on Inhibitor Potency. Biorganic & Medicinal Chemistry Letters 19: 6931–6934, 2009 . Moreau RJ, Schubert CR, Nasr KA, Török M , Miller JS, Kennedy RJ, Kemp DS. Context-Independent, Temperature-Dependent Helical Propensities for Amino Acid Residues. Journal of the American Chemical Society 131: 13107-13116, 2009 . Nasr KA, Schubert CR, , Török M , Kennedy RJ, Kemp DS. Helix-coil energetics for helix formers and breakers reflect context and temperature. Mutants of helically robust, guest-sensitive homopeptide hosts. Biopolymers 91: 311-320, 2009 . Török B, Dasgupta S, Török M . Chemistry of Small Molecule Inhibitors in Self-Assembly of Alzheimer's Disease Related Amyloid-Beta Peptide. Current Bioactive Compounds 4: 159-174, 2008. Mhadgut SC, Török M , Dasgupta S, Török B. Nature of Proline-Induced Enantiodifferentiation in Asymmetric Pd Catalyzed Hydrogenations: Is the Catalyst Really Indifferent? Catalysis Letters 123: 156-163, 2008. Török M , Abid M, Mhadgut SC, Török B. Organofluorine Inhibitors of Amyloid Fibrillogenesis. Biochemistry 45: 5377-5383, 2006.