Ting, Alice Y - Massachusetts Institute of Technology

研究领域

Biological/Materials & Nanoscience/Organic/Physical

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Directed evolution of APEX2 for electron microscopy and proximity labeling.Nature Methods 2014, advance online publication.S. S. Lam, J. D. Martell, K. J. Kamer, T. J. Deerinck, M. H. Ellisman, V. K. Mootha, and A. Y. Ting. Computational design of a red fluorophore ligase for site-specific protein labeling in living cells.Proceedings of the National Academy of Sciences 2014, 111, E4551-E4559.D. S. Liu, L. G. Nivon, F. Richter, P. J. Goldman, T. J. Deerinck, J. Z. Yao, D. Richardson, W. S. Phipps, A. Z. Ye, M. H. Ellisman, C. L. Drennan, D. Baker, and A. Y. Ting. Proteomic mapping of the human mitochondrial intermembrane space in live cells via ratiometric APEX tagging. Molecular Cell 2014, 55, 332-341.V. Hung, P. Zou, H.-W. Rhee, N. D. Udeshi, V. Cracan, T. Svinkina, S. A. Carr, V. K. Mootha, and A. Y. Ting. Site-specific protein labeling using PRIME and chelation-assisted click chemistry. Nature Protocols 2013, 8, 1620-1634.C. Uttamapinant, M. I. Sanchez, D. S. Liu, J. Z. Yao, K. A. White, S. Grecian, S. Clark, K. R. Gee, and A. Y. Ting. Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging. Science 2013, 339, 1328-1331.Highlight in Nature MethodsH.-W. Rhee, P. Zou, N. D. Udeshi, J. D. Martell, V. K. Mootha, S. A. Carr, and A. Y. Ting. Imaging trans-cellular neurexin-neuroligin interactions by enzymatic probe ligation. PLoS One 2013, 8, e52823.D. S. Liu, K. H. Loh, S. S. Lam, K. A. White, and A. Y. Ting. Quantum dot targeting with lipoic acid ligase and HaloTag for single-molecule imaging on living cells.ACS Nano 2012, 6, 11080-11087.D. S. Liu, W. S. Phipps, K. H. Loh, M. Howarth, and A. Y. Ting. Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy. Nature Biotechnology 2012, 30, 1143-1148.Highlight in Nature MethodsJ. D. Martell, T. J. Deerinck, Y. Sancak, T. L. Poulos, V. K. Mootha, G. E. Sosinsky, M. H. Ellisman, and A. Y. Ting. Fast, cell-compatible click chemistry with copper-chelating azides for biomolecular labeling. Angewandte Chemie International Edition 2012, 51, 5852-5856.Highlight in Nature Chemical BiologyC. Uttamapinant, A. Tangpeerachaikul, S. Grecian, S. Clarke, U. Singh, P. Slade, K. R. Gee, and A. Y. Ting. Site-specific protein modification using lipoic acid ligase and bis-aryl hydrazone formation. ChemBioChem 2012, 13, 888-894.J. D. Cohen, P. Zou, and A. Y. Ting. Fluorophore targeting to cellular proteins via enzyme-mediated azide ligation and strain-promoted cycloaddition. Journal of the American Chemical Society 2012, 134, 3720-3728.J. Z. Yao, C. Uttamapinant, A. Poloukhtine, J. M. Baskin, J. A. Codelli, E. M. Sletten, C. R. Bertozzi, V. V. Popik, and A. Y. Ting. Diels-Alder cycloaddition for fluorophore targeting to specific proteins inside living cells. Journal of the American Chemical Society 2012, 134, 792-795.D. S. Liu, A. Tangpeerachaikul, R. Selvaraj, M. T. Taylor, J. M. Fox, and A. Y. Ting. Imaging protein-protein interactions inside living cells via interaction-dependent fluorophore ligation. Journal of the American Chemical Society 2011, 133, 19769-19776.S. A. Slavoff, D. S. Liu, J. D. Cohen, and A. Y. Ting. Structure-guided engineering of a Pacific Blue fluorophore ligase for specific protein imaging in living cells.Biochemistry 2011, 50, 8221-8225.J. D. Cohen, S. Thompson, and A. Y. Ting. Imaging LDL receptor oligomerization during endocytosis using a co-internalization assay.ACS Chemical Biology 2011, 6, 308-313.P. Zou and A. Y. Ting. Synthesis of 7-aminocoumarin via Buchwald-Hartwig cross coupling for specific protein labeling in living cells.ChemBioChem 2011, 12, 65-70.X. Jin, C. Uttamapinant, and A. Y. Ting. A fluorophore ligase for site-specific protein labeling inside living cells.Proceedings of the National Academy of Sciences 2010, 107, 10914-10919.C. Uttamapinant, K. A. White, H. Baruah, S. Thompson, M. Fernández-Suárez, S. Puthenveetil, and A. Y. Ting. Yeast display evolution of a kinetically-efficient 13-amino acid substrate for lipoic acid ligase.Journal of the American Chemical Society 2009, 131, 16430-16438.S. Puthenveetil, D. S. Liu, K. A. White, S. Thompson, and A. Y. Ting. Research articles 2008-2004An engineered aryl azide ligase for site-specific mapping of protein-protein interactions through photocrosslinking. Angewandte Chemie International Edition 2008, 47, 7018-7021.H. Baruah, S. Puthenveetil, Y.-A. Choi, S. Shah, and A. Y. Ting. Protein-protein interaction detection in vitro and in cells by proximity biotinylation.Journal of the American Chemical Society 2008, 130, 9251-9253.M. Fernández-Suárez, T. S. Chen, and A. Y. Ting.