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个人简介

2003年于中科院长春应用化学研究所安立佳研究员(中国科学院院士)指导下获得高分子物理与化学硕士学位,2008年于加拿大多伦多大学Eugenia Kumacheva教授(英国皇家科学院、加拿大皇家科学院院士)指导下获得高分子材料与化学博士学位。2008-2010年间于哈佛大学George M. Whiteside教授(美国科学院、工程院、艺术与科学院三院院士)研究组进行NSERC博士后研究。2011年受聘为马里兰大学帕克分校化学与生物化学系助理教授开展教学和科研工作,并于2017年获得终身教职。目前为复旦大学高分子科学系特聘教授(全职)。 学术专长 主要研究方向为聚合物和粒子合成与自组装、生物成像与药物释放、仿生复合材料、微流控等。迄今在Science, Nat. Materials., Nat. Nanotech., Nat. Commun., J. Am. Chem. Soc., Angew. Chem. Int. Ed.等期刊发表论文130余篇,论文被引用12000余次。 奖励荣誉 曾荣获国家杰出青年科学基金、美国自然科学基金会杰出青年教授奖、3M公司青年教授奖、美国化学会石油研究基金奖、马里兰大学优秀教授奖、加拿大自然科学与工程研究理事会博士后奖、加拿大CAGS/UMI优秀博士论文奖、加拿大MSED/LANXESS博士论文奖、多伦多大学优秀化学博士奖、国家优秀自费留学生奖学金等奖项。 教育和工作经历 1996 - 2000 吉林大学化学系 工学学士 2000 - 2003 中科院长春应用化学研究所 硕士 2003 - 2008 加拿大多伦多大学化学系 理学博士 2008 - 2010 哈佛大学化学与化学生物系 NSERC博士后 2011 - 2017 美国马里兰大学帕克分校化学与生物化学系 终身轨道制助理教授 2017 - 2018 美国马里兰大学帕克分校化学与生物化学系 终身副教授(tenured associate professor) 2019 – 至今 复旦大学高分子科学系 教授

研究领域

聚合物与纳米粒子精准自组装 等离激元功能序构材料 自组装材料在生物成像、诊断和治疗的应用 仿生智能形变高分子材料 微流控反应器及生物芯片

近期论文

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Yue Wu, Yanqiong Yang, Yan Zhang, Liwei Dai, Wenhao Dong, Huibin He, Hao Li, Zhihong Nie*and Yutao Sang*. Photo-Induced Self-assembly of Copolymer-Capped Nanoparticles into Colloidal Molecules. Angewandte Chemie International Edition, 2023, e202313406. Jing Liu, Wenhao Dong, Yifan Xia, Di Zheng, Xiaozheng Duan* and Zhihong Nie*. Regulating the Conformational and Macroscopic Properties of Inorganic Nanowires by Polymer Grafts. Advanced Functional Materials, 2023, 2305587. Huibin He, Xiaoxue Shen and Zhihong Nie*. Engineering Interactions between Nanoparticles Using Polymers. Progress in Polymer Science, 2023, 143,101710. Zhiyuan Lin, Yutao Sang* and Zhihong Nie*. Stepwise Self-assembly of Bottlebrush Random Copolymers into Uniform Cylindrical Structures. Colloid and Polymer Science, 2023, 301, 1021-1028. Fan Yang, Qianyun Chen, Jiajun Wang, Julia J. Chang, Wenhao Dong, Wei Cao, Shunsheng Ye, Lei Shi*, and Zhihong Nie*. Fabrication of Centimeter-Scale Plasmonic Nanoparticle Arrays with Ultranarrow Surface Lattice Resonances. ACS Nano, 2023, 17, 725-734. Wenhao Dong, Zhimao Yang, Jie He, Chuncai Kong and Zhihong Nie*. Vesicular Self-assembly of Copolymer-grafted Nanoparticles with Anisotropic Shapes. Soft Matter, 2023, 19, 634-639. Wenhao Dong, Yan Zhang, Chenglin Yi, Julia J. Chang, Shunsheng Ye and Zhihong Nie*. Halogen Bonding-Driven Reversible Self-Assembly of Plasmonic Colloidal Molecules. ACS Nano, 2023, 17, 3047-3054. Yazi Wang, Hongyan Li, Jiao Chu, Yifan Xia, Shunsheng Ye, Fan Yang, Wei Cao, Jun-Yi Ge, Yifei Xu, Meifang Zhu, Hongyu Pan* and Zhihong Nie*. Site-Selective Assembly of Centimeter-Scale Arrays of Precisely Oriented Magnetic Nanoellipsoids. ACS Nano, 2022, 16, 21208-21215. Jincai Yin, Wenxin Fan*, Zihan Xu, Jinghua Duan, Yanzhi Xia, Zhihong Nie* and Kunyan Sui*. Precisely Defining Local Gradients of Stimuli-Responsive Hydrogels for Complex 2D-to-4D Shape Evolutions. Small, 2022, 18, 2104440. Zihan Xu, Wenxin Fan*, Jinghua Duan, Yanzhi Xia, Zhihong Nie and Kunyan Sui*.Construction of 3D Shape-Changing Hydrogels via Light-Modulated Internal Stress Fields. Engery & Environmental Materials, 2022, 6, e12375. Kuikun Yang, Zhiqing Yang, Guocan Yu*, Zhihong Nie*, Ruibing Wang* and Xiaoyuan Chen*. Polyprodrug Nanomedicines: An Emerging Paradigm for Cancer Therapy. Advanced Materials, 2022, 34, 2107434. Shunsheng Ye, Huaining Zha, Yifan Xia, Wenhao Dong, Fan Yang, Chenglin Yi, Jing Tao, Xiaoxue Shen, Dong Yang* and Zhihong Nie*. Centimeter-Scale Superlattices of Three-Dimensionally Orientated Plasmonic Dimers with Highly Tunable Collective Properties. ACS Nano, 2022, 16, 4609-4618. Yan Zhang, Chenglin Yi, Wenhao Dong, Di Zheng, Yiqun Yang, Wei Li, Xiaozheng Duan*, Dong Yang* and Zhihong Nie*. Single Copolymer Chain-Templated Synthesis of Ultrasmall Symmetric and Asymmetric Silica-Based Nanoparticles. Advanced Functional Materials, 2022, 32, 2112742. Ning-Ning Zhang, Xiaoxue Shen, Kun Liu*, Zhihong Nie* and Eugenia Kumacheva*. Polymer-Tethered Nanoparticles: From Surface Engineering to Directional Self-Assembly. Accounts of Chemical Research, 2022, 55, 1503-1513. Xiaoxue Shen, Yan Zhang, Huibin He, Chenglin Yi, Wenhao Dong, Shunsheng Ye, Di Zheng, Jing Tao, Qi Wu, Xiaozheng Duan* and Zhihong Nie*. Electrostatic Adsorption Behaviors of Charged Polymer-Tethered Nanoparticles on Oppositely Charged Surfaces. Macromolecular Rapid Communications, 2022, 43, 2200171. Mingyu Du, Delin Zhang, Wenxin Fan*, Kai Zhao, Yanzhi Xia, Zhihong Nie* and Kunyan Sui*. Ionic Diode-based Self-powered Ionic Skins with Multiple Sensory Capabilities. Materials Today Physics, 2022, 26, 100744. Yan Zhang, Wenhao Dong, Yazi Wang, Qi Wu, Chenglin Yi, Yiqun Yang, Yifei Xu and Zhihong Nie*. Synthesis of Patchy Nanoparticles with Symmetry Resembling Polar Small Molecules. Small Methods, 2022, 6, 2200545. Yingying Liu, Wenwen Hou, Pengfei Qi, Jie Yang, Xuelai Xie, Min Lin*, Yanzhi Xia, Zhihong Nie and Kunyan Sui*. Hierarchical Nano-helix as a New Reinforcing Unit for Simultaneously Ultra-strong and Super-tough Alginate Fibers. Carbohydrate Polymers, 2022, 297, 119998. Guangdong Chen, Hanwen Pei, Xuefei Zhang, Wei Shi, Mingjie Liu, Charl F. J. Faul, Bai Yang, Yan Zhao, Kun Liu, Zhongyuan Lu*, Zhihong Nie* and Yang Yang*. Liquid-crystalline Behavior on Dumbbell-shaped Colloids and the Observation of Chiral Blue Phases. Nature Communications, 2022, 13, 5549. Y.Q. Yang, C.L. Yi, X.Z. Duan, Q. Wu, Y. Zhang, J. Tao, W.H. Dong, Z.H. Nie*, Block-random copolymer micellization-mediated formation of polymeric patches on gold nanoparticles, J. Am. Chem. Soc., 2021, DOI: 10.1002/adma.202100325. F. Yang, S.S. Ye, W.H. Dong, D. Zheng, Y.F. Xia, C.L. Yi, J. Tao, C. Sun, L. Zhang, L. Wang, Q.J. Chen, Y.Z. Wang, Z.H. Nie*, Laser scanning-guided assembly of quasi-3d patterned arrays of plasmonic dimers for information encryption, Adv. Mater., 2021, DOI: 10.1002/adma.202100325. L. Hou*, D.D. Chen, R.T. Wang, R.B. Wang, H.J. Zhang, Z.Z. Zhang, Z.H. Nie*, S.Y. Lu*, Transformable honeycomb-like nanoassemblies of carbon dots for regulated multisite delivery and enhanced antitumor chemoimmunotherapy, Angew. Chem. Int. Ed., 2021, DOI: anie.202014397. K.K. Yang, S.Y. Zhang, J. He, Z.H. Nie*, Polymers and inorganic nanoparticles: A winning combination towards assembled nanostructures for cancer imaging and therapy,Nano Today, 2021, 36, 101046. D. Zheng, K.K. Yang, Z.H. Nie*, Precision nanoparticles and nanoassemblies for biomedical delivery and therapy, VIEW, 2021, DOI: 10.1002/VIW.20200067. Z.W. Zhao, X. Wang, X.X. Jing, Y.J. Zhao, K. Lan, W. Zhang, L.L. Duan, D.Y. Guo, C.Y. Wang, L. Peng, X.M. Zhang, Z.S. An, W. Li, Z.H. Nie, C.H. Fan, D.Y. Zhao*, General synthesis of monodispersed ultrafine hybrid nanoparticles from highly-stable monomicelles, Adv. Mater., 2021, DOI: 10.1002/adma.202100820. C.L. Yi, H. Liu, S.Y. Zhang, Y.Q. Yang, Y. Zhang, Z.Y. Lu, E. Kumacheva*, Z.H. Nie*,Self-limiting directional nanoparticle bonding governed by reaction stoichiometry, Science, 2020, 369 (6509), 1369-1374. X.Y. Lin, S.S. Ye, C.C. Kong, K. Webb, C.L. Yi, S.Y. Zhang, Q. Zhang, J. Fourkas, Z.H. Nie*,Polymer ligand-mediated regioselective bonding of plasmonic nanodiscs and nanospheres, J. Am. Chem. Soc., 2020, 142, 17282?17286. N. Li, F, Wu, Z. H. Han, X.F. Wang, Y. Liu, C.L. Yi, S.S. Ye, G.W. Lu, L. Yu, Z.H. Nie*, B.Q. Ding*,Shape complementarity modulated self-assembly of nanoring and nanosphere hetero-nanostructures, J. Am. Chem. Soc., 2020, 142 (27), 11680–11684. C. Lamar, Y.J. Liu, C.L. Yi, Z.H. Nie*,Entropy-driven segregation and budding in hybrid vesicles of binary nanoparticle amphiphiles, Giant, 2020, 1, 100010. C.L. Yi, B. Liu, Y.Q. Yang, J. He,*Z.H. Nie*,Polymer-guided assembly of inorganic nanoparticles, Chem. Soc. Rev., 2020, 49, 465-508. H.Y. Duan, Y.Q. Yang, Y. Zhang, C.L. Yi, Z.H. Nie*, J. He*,What is next in polymer-grafted plasmonic nanoparticles?Giant, 2020, 4, 100033. Y. Tang, Y.J. Ji, C.L. Yi, D. Cheng, B. Wang, Y. Fu, Y.F. Xu, X.H. Qian, Y.E. Choonara, V. Pillay, W.P. Zhu*, Y.E. Liu*, Z.H. Nie*,Self-accelerating H2O2-responsive plasmonic nanovesicles for synergistic chemo/starving therapy of tumors, Theranostics, 2020, 10(19), 8691-8704. Z. Hu, E. Prince, P. Narayanan, K. Liu,* Z.H. Nie,* E. Kumacheva*,Colloidal stability of nanoparticles stabilized with mixed ligands in solvents with varying polarity, Chem. Comm., 2020, 56(58), 8131-8134. C. Qi, C. Jiang, L.H. Fu, T.W. Sun, TF. Wang, J. Lin, Z.H. Nie*, P. Huang*,Melanin-instructed biomimetic synthesis of copper sulfide for cancer phototheranostics, Chem. Eng.J., 2020, 388 (15), 124232. H.Y. Guo*, Q. Zhang, W. Liu, Z.H. Nie,Light-mediated shape transformation of self-rolling nanocomposite hydrogel tube, ACS Appl. Mater. & Inter., 2020, 12, 11, 13521–13528. W.X. Fan,J.C. Yin, C.L. Yi,Y.Z. Xia,*Z.H. Nie,* K.Y. Sui*,Nature-inspired sequential shape transformation of energy-patterned hydrogel sheets, ACS Appl. Mater. & Inter., 2020, 12, 4, 4878-4886. C.L. Yi, Y.Q. Yang, Z.H. Nie*,Alternating Copolymerization of inorganic nanoparticles, J. Am. Chem. Soc., 2019,141(19), 7917-7925. W.X. Fan, C.Y. Shan, H.Y. Guo, J.W. Sang, R. Wang, R.R. Zheng, Y.Q. Tan, K.Y. Sui*, Z.H. Nie*,Dual-gradient enabled ultrafast biomimetic snapping of hydrogel materials, Sci. Adv., 2019,5(4), eaav7174. Z.Q. Huang, Z.J. Zhao, Q. Zhang, L.L. Han, X.M. Jiang, C. Li, M.T. Perez Cardenas, P. Huang, J.J. Yin, J. Luo,J.L. Gong*, Z.H. Nie*,A welding phenomenon of dissimilar nanoparticles in dispersion, Nat. Commun.,2019,10 (1), 219. K.K. Yang, Y.J. Liu, Y. Wang, Q.L. Ren, H.Y. Guo, M.B. Matson, X.Y. Chen*, Z.H. Nie*,Enzyme-induced in vivo assembly of gold nanoparticles for imaging-guided synergistic chemo-photothermal therapy of tumor, Biomaterials,2019, 223,119460. Z.Q. Huang, J.L. Gong*, Z.H. Nie*,Symmetry-breaking synthesis of multicomponent nanoparticles, Acc. Chem. Res., 2019,52, 1125?1133. X.K. Yao, P. Huang*, Z.H. Nie*,Cyclodextrin-based polymer materials: from controlled synthesis to applications, Prog. Polym.Sci., 2019,93, 1-35. X.H. Zhang,N.N. Sheng,L.N. Wang, Y.Q. Tan,C.Z. Liu,Y.Z. Xia, Z.H. Nie*,K.Y. Sui*,Supramolecular nanofibrillar hydrogels as highly stretchable, elastic and sensitive ionic?sensors, Mater. Horizons, 2019,6, 326-333. X.K. Yao,J. Mu, L.L. Zeng, J. Lin, Z.H.Nie,* X.Q. Jiang*, P. Huang*,Stimuli-Responsive cyclodextrin-Based nanoplatforms?for cancer treatment and theranostics, Mater. Horizons, 2019,6, 846-870. Z.Q. Huang, S.H. Liu, Y.J. Zhang, J.L. Yang, J.F. Li, Z.H. Nie*, J.L. Gong*,Regioselective metal deposition on polymer-Au nanoparticle hybrid chains, Sci. China Mater., 2019, 62(9),1363–1367. H.Y. Guo, J. Cheng, K.K. Yang, G.Y. Wu, K. Demella, T. Li, S.R. Raghavan, Z.H. Nie*,Programming the shape transformation of composite hydrogel sheet via?erasable and rewritable nanoparticle patterns, ACS Appl. Mater. & Inter., 2019,11, 45, 42654-42660. F. Gombedza, S. Evans, S. Shin, E. A. Boadi, Q. Zhang, Z.H. Nie, B.C. Bandyopadhyay*,Melamine promotes calcium crystal formation in three-dimensional microfluidic device, Sci. Rep., 2019,9, 875. J. Cheng,Z. Jia,H.Y. Guo, Z.H. Nie, T. Li*,Delayed burst of a gel balloon, J. Mech. Phys. Solids, 2019,124, 143-158. L.P. Song, L. Zhang, K. Xu, Y.J. Huang,* P. Gao, H.Y. Fang, J.W. Zhang, Z.H. Nie and T. Chen*,Fluorescent microsphere probe for rapid qualitative and quantitative detection of trypsin activity, Nanoscale Advances, 2019, 1, 162-167. S.H. Chen, Z.H. Wang, X.Y. Cui, L.L. Jiang, Y.E. Zhi, X.T. Ding, Z.H. Nie, P. Zhou, D.X. Cui,Microfluidic device directly fabricated on screen-printed electrodes for ultrasensitive electrochemical sensing of PSA, NanoscaleRes. Lett., 2019, 14 (1), 71. Y. Yang, G.D. Chen, K. Liu,* Z.H. Nie,*Synthesis and phase behaviors of colloidal cuboids with tunable shape biaxiality,Nat. Commun.,2018, 9, 4513. Featuredon Editors’ Highlights webpage of recent research on Organic Chemistry and Chemical Biology:https://www.nature.com/collections/ed-highlights-org-bio-chemistry. H.Y. Guo, Y.J. Liu, Y. Yang, G.Y. Wu, K. Demella, S.R. Raghavan and Z.H. Nie*,A Shape-shifting composite hydrogel sheet with spatially patterned plasmonic nanoparticles, J. Mater. Chem. C, 2018, 7, 1679-1683 . Y.J. Liu,Z. Yang, X.L. Huang, G.C. Yu, S. Wang, Z.J. Zhou, Z.Y. Shen, W.P. Fan, Y. Liu,M. Davisson,H. Kalish, G. Niu, Z.H.Nie,*X.Y. Chen*,Glutathione-Responsive Self-Assembled Magnetic Gold Nanowreath for Enhanced Tumor Imaging and Imaging-Guided Photothermal Therapy,ACS Nano,2018, 12 (8), 8129–8137. Y.C. Li, M. D. Weir, N. Gu, R. Masri, Y. Xia, J.P. Ruan, X.F. Chang, Z.H. Nie, X. Y. Lin, Y.D. Ji, X.Y. Hu, H.K. Xu,Novel magnetic nanoparticle-containing adhesive with greater dentin bond strength and antibacterial and remineralizing capabilities,Dental Materials, 2018, 34(9), 1310-1322. X.L. Huang, Y.J. Liu, J. Barr, J.B. Song, Z.M. He, Y.M. Wang,Z.H. Nie, Y.H. Xiong*, X.Y. Chen*.Controllable self-assembled plasmonic vesicle-based three dimensional SERS platform for picomolar detection of hydrophobic contaminants, Nanoscale,2018,10, 13202-13211. K.K. Yang,Y.J. Liu, Y. Liu, Q. Zhang, C.C. Kong, C.L. Yi, Z.J. Zhou, Z.T. Wang, G.F. Zhang, Y. Zhang,N.M. Khachab*, X.Y. Chen*, Z.H. Nie*,Cooperative assembly of magneto-nanovesicles with tunable wall thickness and permeability for MRI-guided drug delivery,J. Am. Chem. Soc., 2018, 140(13), 4666-4677. Y. Yang, H.W. Pei, G.D. Chen, K. Webb, L.J. Martinez-Miranda, I.K. Lloyd, Z.Y. Lu*, K. Liu*,Z.H. Nie*,Phase behaviors of colloidal analogues of bent-core liquid crystals,Sci. Adv.,2018,4(5),eaas8829. Y.D. Ji, S.K. Choi, A.S. Sultan, C.C. Kong, X.Y. Lin, E. Dashtimoghadam, M.A. Melo, M. Weir, H.K. Xu, L. Tayebi, Z.H. Nie, D.A. Depireux, R. Masri,Nanomagnetic-mediated drug delivery for the treatment of dental disease, Nanomedicine, 2018,14(3), 919-927. Perez-Cardenas, C.C. Kong, J. He, S. Litvin, M.L. Meyerson, Z.H. Nie*,Immobilized seed-mediated growth of two-dimensional array of metallic nanocrystals with asymmetric shapes, ACS Nano, 2018,12(2), 1107–1119.

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