个人简介

Degrees Ph.D. in Biological Chemistry, University of Pennsylvania

研究领域

Enzyme structure and mechanism, Macromolecular X-ray crystallography, Enzymology, Molecular Biology, Metalloenzymes, Iron-sulfur clusters, Vitamin B12, S-adenosyl-L-methionine and adenosylcobalamin radical enzymes, Posttranslational modifying enzymes, Posttranscriptional modifying enzymes, Natural product biosynthesis

We primarily use X-ray crystallography and biochemical techniques to study the structure and function of important biological systems. Our research focuses on two main areas: Challenging chemistry in natural product biosynthesis and posttranslational or posttranscriptional modifying enzymes.

近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

D.P. Dowling, R.M. McCarty, A.P. Young, N.A. Bruender, V. Bandarian, C.L. Drennan. “Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism” Nat. Chem. Biol., 2014, 10, 106-112. *Selected as Cover Art Feature D.P. Dowling, J.L. Vey, A.K. Croft, C.L. Drennan. “Structural diversity in the AdoMet radical enzyme superfamily” BBA-Prot. Proteom., 2012, 1824, 1178-1195. D.P. Dowling, A.K. Croft, C.L. Drennan. “Radical use of Rossmann and TIM barrel architectures for controlling coenzyme B12 Chemistry” Annu. Rev. Biophys., 2012, 41, 403-427. M.L. Ilies, D.P. Dowling, P.M. Lombardi, D.W. Christianson. “Synthesis of a new trifluoromethylketone analogue of L-arginine and contrasting inhibitory activity against human arginase I and histone deacetylase 8” Bioorg. Med. Chem. Lett., 2011, 21, 5854-5858. M.L. Ilies, L.Di Costanzo, D.P. Dowling, K.J. Thorn, D.W. Christianson. “Binding of a,a-disubstituted amino acids to arginase suggests new avenues for inhibitor design” J. Med. Chem., 2011, 54, 5432-5443. P.M. Lombardi, K.E. Cole, D.P. Dowling, D.W. Christianson. “Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes” Curr. Opin. Struct. Biol., 2011, 21, 735-743. K.E. Cole, D.P. Dowling, M.A. Boone, A.J. Phillips, D.W. Christianson. “Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases” J. Am. Chem. Soc., 2012, 133, 12474-12477. D.P. Dowling, M.L. Ilies, K.L. Olszewski, S.P. Portugal, M.M. Mota, M. Llinás, D.W. Christianson. “Crystal structure of arginase from Plasmodium falciparum and implications for L-arginine depletion in malarial infection” Biochemistry, 2010, 49, 5600-5608. D.P. Dowling, S.G. Gattis, C.A. Fierke, D.W. Christianson. “Metal-substituted histone deacetylase structures” Biochemistry, 2010, 49, 5048-5056. D.P. Dowling, S.L. Gantt, S.G. Gattis, C.A. Fierke, D.W. Christianson. “Structural studies of histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors” Biochemistry, 2008, 47, 13554-13563. D.P. Dowling, L.Di Costanzo, H.A. Gennadios, and D.W. Christianson. “Evolution of the arginase fold and functional diversity” Cell. Mol. Life Sci., 2008, 65, 2039-2055. C.S. Higham, D.P. Dowling, J.L. Shaw, A. Cetin, C.J. Zielgler, J.R. Farrell. “Multidentate aminophenol ligands prepared with Mannich condensations” Tet. Lett. 2006, 47, 4419-4423.