Stubbe, JoAnne - Massachusetts Institute of Technology

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Cotruvo, J.A.; Stubbe, J. An Active Dimanganese(III)-Tyrosyl Radical Cofactor in Escherichia coli Class Ib Ribonucleotide Reductase. Biochemistry Articles ASAP. Lohman, G.J.S.; Gerfen, G.J.; Stubbe, J. Inactivation of Lactobacillus leichmannii ribonucleotide reductase by F2CTP: adenosylcobalamin destruction and formation of a nucleotide based radical. Biochemistry Just Accepted. Lohman, G.J.S.; Stubbe, J. Inactivation of Lactobacillus leichmannii ribonucleotide reductase by F2CTP: covalent modification. Biochemistry Just Accepted. Shanmugam, M.; Doan, P.E.; Lees, N.S.; Stubbe, J.; Hoffman, B.M. Identification of Protonated Oxygenic Ligands of Ribonucleotide Reductase Intermediate X. J. Am. Chem. Soc. 2009, 131, 3370-3376. Artin, E,; Wang, J.; Lohman, G.J.S.; Yokoyama, K.; Yu, G.; Griffin, R.G.; Bar, G.; Stubbe, J. Insight into the Mechanism of Inactivation of Ribonucleotide Reductase by Gemcitabine 5'-Diphosphate in the Presence or Absence of Reductant. Biochemistry 2009, 48, 11622-11629. Wang, J.; Lohman, G.J.S.; Stubbe, J. Mechanism of Inactivation of Human Ribonucleotide Reductase with p53R2 by Gemcitabine 5'-Diphosphate. Biochemistry 2009, 48, 11612-11621. Reece, S.Y.; Lutterman, D.A.; Seyedsayamdost, M.R.; Stubbe, J.; Nocera, D.G. Re(bpy)(CO)3CN as a Probe of Conformational Flexibility in a Photochemical Ribonucleotide Reductase. Biochemistry 2009, 48, 5832-5838. Seyedsayamdost, M.R.; Stubbe, J. Replacement of Y730 and Y731 in the α2 subunit of Escherichia coli ribonucleotide reductase with 3-aminotyrosine using an evolved suppressor tRNA/tRNA-synthetase pair. Methods Enzymol. 2009, 462, 45-76. Seyedsayamdost, M.R.; Argirevic, T.; Minnihan, E.C.; Stubbe, J.; Bennati, M. Structural Examination of the Transient 3-Aminotyrosyl Radical on the PCET Pathway of E. coli Ribonucleotide Reductase by Multifrequency EPR Spectroscopy. J. Am. Chem. Soc. 2009, 131, 15729-15738. Zipse, H.; Artin, E.; Wnuk, S.; Lohman, G.J.S.; Martino, D.; Griffin, R.G.; Kacprzak, S.; Kaupp, M.; Hoffman, B.; Benatti, M.; Stubbe, J.; Lees, N. Structure of the Nucleotide Radical Formed during Reaction of CDP/TTP with the E441Q-α2β2 of E. coli Ribonucleotide Reductase. J. Am. Chem. Soc. 2009, 131, 200-211. Minnihan, E.C.; Seyedsayamdost, M.R.; Stubbe, J. Use of 3-Aminotyrosine To Examine the Pathway Dependence of Radical Propagation in Escherichia coli Ribonucleotide Reductase. Biochemistry 2009, 48, 12125-12132. Lee, Y.D.; Wang, J.; Stubbe, J; Elledge, S.J. Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase. Molecular Cell 2008, 32, 70-80. Hassan, A.Q.; Stubbe, J. Mapping the subunit interface of ribonucleotide reductase (RNR) using photo cross-linking. Bioorganic & Medicinal Chemistry Letters 2008, 18, 5923-5925. Hassan, A.Q.; Wang, Y.; Plate, L.; Stubbe, J. Methodology to probe subunit interactions in ribonucleotide reductases. Biochemistry 2008, 47, 13046-13055. Cotruvo, J.A. Jr.; Stubbe, J. NrdI, a flavodoxin involved in maintenance of the diferric-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase. Proc. Natl. Acad. Sci. USA 2008, 105, 14383-14388. Hristova D.; Wu, C.-H.; Jiang, W.; Krebs, C.; Stubbe, J. Importance of the maintenance pathway in the regulation of the activity of Escherichia coli ribonucleotide reductase. Biochemistry 2008, 47, 3989-3999. Seyedsayamdost, M.R.; Xie, J.; Chan, C.T.; Schultz, P.G.; Stubbe, J. Site-specific insertion of 3-aminotyrosine into subunit α2 of E. coli ribonucleotide reductase: direct evidence for involvement of Y730 and Y731 in radical propagation. J. Am. Chem. Soc. 2007, 129, 15060-15071. Wang, J.; Lohman, G.J.S.; Stubbe, J. Enhanced subunit interactions with gemcitabine-5?-diphosphate inhibit ribonucleotide reductases. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 14324-14329. Wu, C.-H.; Jiang, W.; Krebs, C.; Stubbe, J. YfaE, a ferredoxin involved in diferric-tyrosyl radical maintenance in E. coli ribonucleotide reductase. Biochemistry 2007, 46, 11577-11588. Seyedsayamdost, M.R.; Yee, C.S.; Reece, S.Y.; Nocera, D.G.; Stubbe, J. pH rate profiles of FnY356-R2s (n = 2, 3, 4) in Escherichia coli ribonucleotide reductase: Evidence that Y356 is a redox-active amino acid along the radical propagation pathway. J. Am. Chem. Soc., 2006, 128, 1562-1568.

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