Shoulders, Matthew D. - Massachusetts Institute of Technology

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Genereux, J.C.; Qu, S.; Zhou, M.; Ryno, L.M.; Wang, S.; Shoulders, M.D.; Kaufman, R.J.; Lasmézasm C.I.; Kelly, J.W.; Wiseman, R.L. "Unfolded Protein Response-Induced ERdj3 Secretion Links Endoplasmic Reticulum Stress to Extracellular Proteostasis" EMBO Journal 2015, 34, 4–19. Choudhary, A.; Kamer, K.J.; Shoulders, M.D.; Raines, R.T. "4-Ketoproline: An electrophilic proline analog for bioconjugation" Biopolymers: Peptide Science 2015, in press. Chen, J.J.; Genereux, J.C.; Hulleman, J.D.; Shoulders, M.D.; Wiseman, R.L. “ATF6 Activation Reduces the Secretion and Extracellular Aggregation of Destabilized Variants of an Amyloidogenic Protein" Chemistry and Biology 2014, 21, 1564–1574. Ryno, L.M.; Genereux, J.C.; Naito, T.; Morimoto, R.I.; Powers, E.T.; Shoulders, M.D.; Wiseman, R.L. "Characterizing the Altered Cellular Proteome Induced by the Stress-Independent Activation of Heat Shock Factor I" ACS Chemical Biology 2014, 9,1273–1283. Shoulders, M.D.; Ryno, L.M.; Kelly, J.W.; Wiseman, R.L. “Broadly Applicable Methodology for the Dosable, Rapid, and Small Molecule-Mediated Regulation of Transcription Factors in Human Cells”Journal of the American Chemical Society 2013, 135, 8129–8132. Shoulders, M.D.; Ryno, L.M.; Genereux, J.C.; Moresco, J.J.; Tu, P.G.; Wu, C.; Yates, J.R. III; Su, A.I.; Kelly, J.W.; Wiseman, R.L. “Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments” Cell Reports 2013, 3, 1279–1292. Krow, G.R.; Shoulders, M.D.; Edupuganti, R.; Gandla, D.; Yu, F.; Sonnet, P.E.; Sender, M.; Choudhary, A.; DeBrosse, C.; Ross, C.W.,III; Carroll, P.; Raines, R.T. “Synthesis of 5-Fluoro- and 5-Hydroxymethanoprolines via Lithiation of N-BOC-Methanopyrrolidines. Constrained Cg-Exo and Cg-Endo Flp and Hyp Conformer Mimics” Journal of Organic Chemistry 2012, 77, 5331–5344. Shoulders, M.D.; Raines, R.T. “Interstrand Dipole-Dipole Interactions Can Stabilize the Collagen Triple Helix” Journal of Biological Chemistry 2011, 286, 22905–22912. Krow, G.R.; Edupuganti, R.; Gandla, D.; Yu, F.; Sender, M.; Sonnet, P.E.; Zdilla, M.J.; DeBrosse, C.; Cannon, K.C.; Ross, C.W., III; Choudhary, A.; Shoulders, M.D.; Raines, R.T. “Synthesis of Conformationally Constrained 5-Fluoro- and 5-Hydroxymethanopyrrolidines. Ring Puckered Mimics of Gauche and Anti-3-Fluoro- and 3-Hydroxypyrrolidines” Journal of Organic Chemistry 2011, 76, 3626–3634. Shoulders, M.D.; Kotch F.W.; Choudhary, A.; Guzei, I.A.; Raines, R.T. “The Aberrance of the 4S Diastereomer of 4-Hydroxyproline” Journal of the American Chemical Society, 2010, 132, 10857–10865. Shoulders, M.D.; Satyshur, K.A.; Forest, K.T.; Raines, R.T. “Stereoelectronic and Steric Effects in Side Chains Preorganize a Protein Main Chain” Proceedings of the National Academy of Sciences, USA 2010, 107, 559–564. Krow, G.R.; Liu, N.; Sender, M.; Lin, G.; Centafont, R.; Sonnet, P.E.; DeBrosse, C.; Ross, C.W., III; Carroll, P.J.; Shoulders, M.D.; Raines, R.T. “Oligomers of a 5-Carboxymethanopyrrolidine b-Amino Acid—A Search for Order” Organic Letters 2010, 12, 5438–5441. Shoulders, M.D.; Kamer, K.J.; Raines, R.T. “Origin of the Stability Conferred upon Collagen by Fluorination” Bioorganic and Medicinal Chemistry Letters 2009, 19, 3859–3862. Shoulders, M.D.; Raines, R.T. “Collagen Structure and Stability” Annual Review of Biochemistry 2009,78, 929–958. Shoulders, M.D.; Raines, R.T. “Modulating Collagen Triple-Helix Stability with 4-Chloro, 4-Fluoro, and 4-Methylprolines” Advances in Experimental Medicine and Biology 2009, 611, 251–252. Shoulders, M.D.; Guzei, I.A.; Raines, R.T. “4-Chloroprolines: Synthesis, Conformational Analysis, and Effect on the Collagen Triple Helix” Biopolymers 2008, 89, 443–454. Shoulders, M.D.; Hodges, J.A.; Raines, R.T. “Reciprocity of Steric and Stereoelectronic Effects in the Collagen Triple Helix” Journal of the American Chemical Society 2006, 128, 8112–8113.

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