个人简介

Ph.D., Biochemistry & Molecular Biology, Harvard University B.A., Chemistry, Queens College, CUNY

研究领域

Genomic and epigenetic mechanisms controlling liver gene expression; molecular endocrinology and cell signaling through transcriptional networks; role of angiogenesis and innate immune system in cancer therapy and pharmacology; nuclear receptors and responses to environmental chemicals

Areas of Interest Genomic and epigenetic mechanisms controlling liver gene expression; molecular endocrinology and cell signaling through transcriptional networks; nuclear receptors and responses to environmental chemicals; role of immune system in cancer therapy and pharmacology. Our research program encompasses the following three major questions: 1) How do hormone regulatory circuits and the epigenomic events that they activate regulate complex patterns of gene expression in mammalian tissues? 2) By which mechanisms do environmental chemicals reprogram postnatal gene expression, inducing metabolic dysregulation and impaired reproductive function? 3) Can improved strategies for cancer treatment be devised through a better understanding of the impact of cancer chemotherapy on host-tumor interactions affecting immune responses to cancer therapy?

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Melia T, Hao P, Yilmaz F, Waxman DJ. (2016) Hepatic lincRNAs: high promoter conservation and dynamic, sex-dependent transcriptional regulation by growth hormone. Mol Cell Biol. 2015 Oct 12. pii: MCB.00861-15. [Epub ahead of print] PubMed PMID: 26459762. Suvorov A, Waxman DJ. (2015) Early programing of uterine tissue by bisphenol A: Critical evaluation of evidence from animal exposure studies. Reprod Toxicol. 2015 Nov;57:59-72. doi: 10.1016/j.reprotox.2015.05.008. Epub 2015 May 28. Review. PubMed PMID: 26028543; PubMed Central PMCID: PMC4550532. Conforto TL, Steinhardt GF 4th, Waxman DJ. (2015) Cross Talk Between GH-Regulated Transcription Factors HNF6 and CUX2 in Adult Mouse Liver. Mol Endocrinol. 2015 Sep;29(9):1286-302. doi: 10.1210/me.2015-1028. Epub 2015 Jul 28. PubMed PMID: 26218442; PubMed Central PMCID: PMC4552435. Wu J, Waxman DJ. (2015) Metronomic cyclophosphamide eradicates large implanted GL261 gliomas by activating antitumor Cd8(+) T-cell responses and immune memory. Oncoimmunology. 2015 Feb 18;4(4):e1005521. eCollection 2015 Apr. PubMed PMID: 26137402; PubMed Central PMCID: PMC4485826. Chen CS, Doloff JC, Waxman DJ. (2014) Intermittent metronomic drug schedule is essential for activating antitumor innate immunity and tumor xenograft regression. Neoplasia. 2014 Jan;16(1):84-96. PubMed PMID: 24563621; PubMed Central PMCID: PMC3924543. Sugathan A, Waxman DJ. (2013) Genome-wide analysis of chromatin states reveals distinct mechanisms of sex-dependent gene regulation in male and female mouse liver. Mol Cell Biol. 2013 Sep;33(18):3594-610. doi: 10.1128/MCB.00280-13. Epub 2013 Jul 8. PubMed PMID: 23836885; PubMed Central PMCID: PMC3753870. Conforto TL, Zhang Y, Sherman J, Waxman DJ. (2012) Impact of CUX2 on the female mouse liver transcriptome: activation of female-biased genes and repression of male-biased genes. Mol Cell Biol. 2012 Nov;32(22):4611-27. doi: 10.1128/MCB.00886-12. Epub 2012 Sep 10. PubMed PMID: 22966202; PubMed Central PMCID: PMC3486175. Shao Z, Zhang Y, Yuan GC, Orkin SH, Waxman DJ. (2012) MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets. Genome Biol. 2012 Mar 16;13(3):R16. doi: 10.1186/gb-2012-13-3-r16. PubMed PMID: 22424423; PubMed Central PMCID: PMC3439967.