Lutchen, Kenneth R. - Boston University - Department of Biomedical

个人简介

Dr. Kenneth R. Lutchen, is Dean of the College of Engineering and Professor of Biomedical Engineering at Boston University. He received his B.S. from the University of Virginia and Ph.D from Case Western Reserve University. He has published over 135 peer-reviewed journal articles. Dean Lutchen was Chair of Biomedical Engineering from 1998-2006 over which the department ranking improved from 18th to 6th in the nation. Dr. Lutchen is Past-President of the American Institute of Medical and Biological Engineering (AIMBE). Since becoming Dean, the College’s Graduate Ranking in US News and World Report has improved from 54th to 34th , the largest improvement of any school in the top 54 over that time. Since 2015 he has overseen the creation and resourcing of several new major research centers, including The Biological Design Center, The Precision Diagnostics Center, and the Neurophotonics Center. During his Deanship, he has orchestrated the creation of a new Division of Materials Science and Engineering and a new Division of Systems Engineering and Masters programs in Robotics, Cybersecurity and Data Analytics. Recently, he oversaw the creation of a new 20,000 sq. ft Engineering Product Innovation Center (EPIC) designed to partner with industry to instill interdisciplinary design and product innovation skills throughout engineering education. Dean Lutchen has focused on transforming engineering education to create the Societal Engineer®, an individual who combines their engineering foundation with empowering attributes to address society’s challenges regardless of their career paths. He also drove the creation of a unique Technology Inspiration Ambassador program that trains Engineering students to inspire K-12 students to pursue Engineering. In 5 years this program has reached over 20,000 K-12 students in 26 states. In 2016 Dean Lutchen was honored to be named a member of the Advisory Committee to the Directorate for Engineering of The National Science Foundation. Dr. Lutchen is on the Board of Directors of the Wyss Institute at Harvard and serves several other academic and corporate advisory boards as well as on review panels for the NIH and NSF. Dr. Lutchen has been the recipient of the AIMBE Pierre Galletti Award, AIMBE’s highest honor, and the College of Engineering’s Professor of the Year Award and the Biomedical Engineering Professor of the Year Award — twice.

研究领域

MAJOR RESEARCH AREAS Advanced application of mechanistic and anatomic based models for developing an integrated understanding of the structure-function relations in the lung with emphasis on asthma and COPD Image-based Computational models of integrated lung function for personalized medicine Development of novel measurement, monitoring and signal processing techniques that provide new insights on the structural airway and tissue conditions of the healthy and diseased lung. Advancing new paradigms and technologies for mechanical ventilation base on fundamental biological principals so as to improve diagnostic and therapeutic applications. Advancing linear and nonlinear sensitivity and systems identification science to evaluate the efficacy of applying models to physiological data with emphasis on structural lung models.

近期论文

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Mendonca, N.T. Kenyon, J. LaPrad, A, Syeda, S., O'Connor, G.T. and K.R. Lutchen Airway resistance at maximum inhalation as a marker of asthma and airway hyperresponsiveness. Respiratory Research 12:96 doi:10.1186/1465-9921-12-96; 2011, Lutchen, K. J. Ayers, S. Gallagher, L. Abu-Teleb Engineering Efficient Technology Transfer. Science Translational Medicine, Vol. 3, 1-2, 2011. Lui, J.K., A. S. LaPrad, H. Parameswaran, Y. Sun, M. S. Albert, K. R. Lutchen. Semiautomatic segmentation of ventilated airspaces in healthy and asthmatic subjects using hyperpolarized 3He MRI. Computational and Mathematical Methods in Medicine Article ID 624683, 9 pages, 2013. doi:10.1155/2013/624683. vol. 2013 LaPrad, A.S., K. R. Lutchen, and B. Suki. A Mechanical Design Principle for Tissue Structure and Function in the Airway Tree. PLOS Computational Biology. Comput Biol 9(5): e1003083. doi:10.1371/journal.pcbi.1003083, 2013. Harvey B.C., H. Parameswaran, K. R. Lutchen, Can Tidal Breathing with Deep Inspirations of Intact Airways Create Sustained Bronchoprotection or Bronchodilation? J. Appl. Physiol. 115: 436-445. 2013. H. Parameswaran, B. Suki, and K. R. Lutchen Cytoskeletal network organization determines cellular response to extracellular mechanical environment. J. Appl. Physiol. 116: 825-834, 2014. Lutchen, K. R. Airway smooth muscle stretch and airway hyperresponsiveness in asthma:Have we chased the wrong horse? J. Appl. Physiol. 116: 1113 – 1115, 2014 Lutchen, K.R. A one-horse race can have only one winner. J. Appl. Physiol. 116: 1119, 2014. Harvey, B. and K.R. Lutchen. Factors Determining Airway Caliber in Asthma. Critical Reviews in BME 41(6): 515-532. 2013. Bartolák-Suki, E. A.S. LaPrad, B. Harvey, B. Suki and K. R. Lutchen. Tidal stretches differently regulate the contractile and cytoskeletal elements in intact airways. PLOS One 9(4):e94828. Doc:10.1371/journal.pone.0094828, 9 pages, 2014. Dellaca, R.L., A. Aliverti, A.L. Mauro, K.R. Lutchen, A. Pedotti and B. Suki. Correlated variability in the breathing pattern and end-expiratory lung volumes in conscious humans PLOS One 24 March 2015 Harvey B.C., H. Parameswaran, K. R. Lutchen, Can Breathing-Like stretches prevent or reverse reactivity of small airways? J. Appl. Physiol. 119, 47-54. 2015. Lui, J.K, Parameswaran, H, Albert, M.S., and Lutchen, K.R. Linking ventilation heterogeneity quantified via hyperpolarized 3He MRI to dynamic lung mechanics and airway hyperresponsiveness. PLOS ONE DOI:10 1371/journal.pone.0142738, pgs 1-14; Nov. 2015 Lutchen, KR. How does an airway and subsequently the lung become hyperresponsive. Journal of Applied Physiology, J Appl Physiol 121: 221–222, 2016; Harvey, B.C., K.R. Lutchen, and P.E. Barbone. Spatial distribution of airway wall displacements during breathing and bronchoconstriction measured by ultrasound elastography using finite element image registration ultrasonics. Ultrasonics. 75, 174-184, 2017. K. R. Lutchen, P. D.. Paré, and Chun Y. Seow: Hyperresponsiveness: Relating the Intact Airway to the Whole Lung. J. Appl. Physiology. Invited Review. Vol. 32 no. 4, 322-331 DOI: 10.1152/physiol.00008.2017 June 2017. Lui, J.K and K.R. Lutchen. Role of Heterogeneity in Asthma: A Structure-to-function Perspective Clinical and Translational Medicine Clinical and Translational Medicine. DOI 10.1186/s40169-017-0159-0, 6:29, 2017 Xu Xiaohe K., B.C. Harvey, K.R. Lutchen, B.D. Gelbman, S.L. Monfre, R.E. Coifman and C.E. Forbes: A comparison of a micro-electro-mechanical system airflow sensor with the pneumotach in the forced oscillation technique. Medical Devices: Evidence and Research 2018. Bou Jawde, S, A. J. Walkey, A. Majumdar1, G.T. O’Connor, B. J. Smith3, J.H.T. Bates, K. R. Lutchen, and B. Suki1 A novel approach to assess respiratory mechanics via variable ventilation 3 reveals therapeutic improvement in patients with acute lung injury. (submitted to Nature Bioengineering)