Hasselmo, Michael - Boston University - Biomedical Engineering

个人简介

D.Phil. in Experimental Psychology Oxford University

研究领域

Research Areas Research in my laboratory concerns the cortical dynamics of memory-guided behavior, including effects of neuromodulatory receptors and the role of theta rhythm oscillations in cortical function. Neurophysiological techniques are used to analyze intrinsic and synaptic properties of cortical circuits in the rat, and to explore the effects of modulators on these properties. Computational modeling is used to link this physiological data to memory-guided behavior. Experiments using multiple single-unit recording in behavioral tasks are designed to test predictions of the computational models. Areas of focused research include episodic memory function and theta rhythm dynamics in the entorhinal cortex, prefrontal cortex and hippocampal formation. Research addresses physiological effects relevant to Alzheimer’s disease, schizophrenia and depression.

近期论文

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Kraus BJ, Robinson RJ II, White JA, Eichenbaum H, and Hasselmo ME (2013) Hippocampal ‘time cells’: Time versus path integration. Neuron 78: 1090-1101. McKenzie S, Frank AJ, Kinsky NR, Porter B, Rivière PD, Eichenbaum H (2014) Hippocampal representation of related and opposing memories develop within distinct, hierarchically-organized neural schemas. Neuron 83:202-215. Preston AR and Eichenbaum H (2013) Interplay of the hippocampus and prefrontal cortex in memory. Current Biology 23: R764-R773. Eichenbaum H and Cohen NJ (2014) Can we reconcile the declarative memory and spatial navigation views of hippocampal function? Neuron 83:764-770.