Lakowicz, Joseph R. - University of Maryland-Baltimore - Department of Biochemistry and Molecular Biology

个人简介

1973: Ph.D. in Biochemistry, University of Illinois, Urbana, Illinois 1971: M.S. in Biochemistry, University of Illinois, Urbana, Illinois 1970: B.A. in Chemistry, Maxima Cum Laude, LaSalle College, Philadelphia, Pennsylvania 1969: Temple University, Philadelphia, Pennsylvania (Additional mathematics courses, Summer) 1968: Drexel Institute of Technology, Philadelphia, Pennsylvania (Additional mathematics courses, Summer)

研究领域

This laboratory is involved in the use and development of fluorescence spectroscopic methods. Our present research projects to advance fluorescence technology include two-photon induced fluorescence and the use of light to modify the excited state populations. The continued development of advanced fluorescence methods is performed at the Center for Fluorescence Spec-tro-sco-py, which is a National Resource of the NIH. This cen--ter provides state-of-the-art time and frequency-domain measurements to users from this campus and from other institutions in this country as well as other countries. Our basic science projects include the use of fluorescence to study: Conformational distributions of proteins, nucleic acids, and transfer RNA. Dynamics of proteins and membranes. Transient effects in diffusion in solutions, and in proteins and membranes. Synthesis of fluorescent sensor molecules. Development of fluorescent lifetime imaging microscopy. Multi-photon excitation.

近期论文

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A Wavelength-Ratiometric Fluoride-Sensitive Probe Based on the Quinolinium Nucleus and Boronic Acid Moiety, Badugu, R., Lakowicz, J. R., and Geddes, C. D. (2005). Sensors Actuators B 104:103-110. Fluorescence Enhancement of Fluorophores Tethered to Different Sized Silver colloids Deposited on Glass Substrate, Lukomska, J., Malicka, J., Gryczynski, I., Leonenko, Z., and Lakowicz, J. R. (2005). Biopolymers 77:31-37. Two-photon induced fluorescence of Cy5-DNA in buffer solution and on silver island films, Lukomska, J., Gryczynski, I., Malicka, J., Makowiecz, S., Lakowicz, J., and Gryczinski, Z. (2005). Biochemical and Biophysical Research Communications, 328: 78-84. Nanogold Plasmon Resonance-Based Glucose Sensing. 2. Wavelength- Ratiometirc Resonance Light Scattering, Aslan, K., Lakowicz, J., and Geddes C.D. (2005). Analytical Chemistry, 77: 2007-2014. Metal-enhanced fluorescence: an emerging tool in biotechnology, Aslan, K., Gryczinski, I., Malicka, J., Matveeva, E. Lakowicz, J. ,and Geddes, C.D. (2005) Current Opinion in Biotechnology, 16:1-8 Fast and Slow Deposition of Silver Nanorods on Planar Surfaces: Application to Metal-Enhanced Fluorescence, Aslan, K., Leonenko, Z., Lakowicz. J., and Geddes, C.D. (2005). J. Phys. Chemistry, 109: 3157-3162. Enhanced Fluorescence cyanide detection at physiologically lethal levels: Reduced ICT-based signal transduction, Badugu, R., Lakowicz, J., and Geddes, C.D. (2005). J. Am. Chem.Society, 127: 3635-3641. Rapid depositing of triangular silver nanoplates on planar surfaces: Application to metal-enhanced fluorescence, Aslan, K., Lakowicz, J., and Geddes, C.D. (2005). J. Phys. Chem. B, 109: 6247-6251. A glucose-sensing contact lens: from bench top to patient, Badugu, R., Lakowicz, J., and Geddes, C.D. (2005). Current Opinion in Biotechnology, 16: 100-107. Fluorescence sensors for monosaccharides based on the 6-methylquinolinium nucleus and boronic acid moiety: potential application to ophthalmic diagnostics, Badugu, R., Lakowicz, J., and Geddes, C.D. (2005). Talanta, 65: 762-768. Enhanced lanthanide luminescence using silver nanostructures: Opportunities for a new class of probes with exceptional spectral characteristics, Wu, M., Lakowicz, J., and Geddes, C.D.(2005) Journal of Fluorescence, 15: 53-59. Enhanced ratiometric pH sensing using SNAFL-2 on silver island films- metal-enhanced fluorescence sensing, Aslan, K., Lakowicz, J., Szmacinski, H., and Geddes, C.D. (2005). Journal of Fluorescence, 15: 37-40. Radiative decay engineering 5: metal-enhanced fluorescence and plasmon emission, Lakowicz, J. (2005). Analytical Biochemistry, 337: 171-194. Surface-plasmon-coupled emission of quantum dots, Gryczinski, I., Malicka, J., Jiang, W., Fischer, H., Chan, W., Gryczinski, Z., Grudzinski, W., and Lakowicz, J. (2005). J. Phys.Chem. B, 109: 1088-1093. Wavelength-ratiometric near-physiological pH sensors based on 6-aminoquinolinium boronic acid probes, Badugu, R., Lakowicz, J. R., and Geddes, C. D. (2005). Talanta 66:569-574. Enhanced luminescence of phenyl-phenanthridine dye on aggregated small silver nanoparticles, Zhang, J. and Lakowicz, J. R. (2005). J. Phys. Chem. B, 109:8701-8706. Boronic acid fluorescent sensors for monosaccharide signaling based on the 6-methoxyquinolinium heterocyclic nucleus: progress toward noninvasive and continuous glucose monitoring, Badugu, R., Lakowicz, J., and Geddes, C.D. (2005). Bioorganic and Medicinal Chemistry, 13: 113-119. Metal-enhanced Fluoroimmunoassay on a Silver Film by Vapor Deposition, Zhang, J., Matveeva, E., Gryczynski, I., Leonenko, Z., and Lakowicz, J. R. (2005). J. Phys. Chem. B 109:7969-7975. Surface-enhanced Fluorescence of Fluorescein-Labeled Oligonucleotides Capped on Silver Nanoparticles, Zhang, J., Malicka, J., Gryczynski, I., and Lakowicz, J. R. (2005). J. Phys. Chem. B. 109:7643-7648. Metal-enhanced fluorescence from plastic substrates, Aslan, K., Badugu, R., Lakowicz, J. R., and Geddes, C. (2005). J. Fluorescence 15(2):99-104.