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个人简介

王育才,博士,教授,博士生导师,中国科学院天然免疫与慢性疾病重点实验 2005年于中国科学技术大学获得学士学位;2010年于中国科学技术大学获得博士学位;2011年1月起先后于圣路易斯华盛顿大学生物医学工程系、佐治亚理工学院生物医学工程系及芝加哥大学James Franck研究所从事博士后研究。2015年9月入职中国科学技术大学生命科学学院任教,主持或参与科技部重点研发、基金委重点项目、面上项目等。多年来一直从事纳米材料在癌症治疗及成像领域的研究,在Nat Mater、Nat Commun、PNAS、Nano Letters、ACS Nano国际学术期刊发表研究论文70余篇,引用次数超过5000次,H-index 为39。

研究领域

纳米药物,生物材料,生物医用高分子,显微活体成像

近期论文

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G. Zhang #, Q. Wang #, W. Tao #, W. Jiang, E. Eran, Y. C. Wang* & S. Zhu *. Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis. Nature Biomedical Engineering. 2022, 6, 867-881. L. Wang#, J. Dou#, W. Jiang, Q. Wang, Y. Liu, H. Liu,* and Y. C. Wang*. Enhanced Intracellular Transcytosis of Nanoparticles by Degrading Extracellular Matrix for Deep TissueRadiotherapy of Pancreatic Adenocarcinoma. Nano Letters. 2022, 22, 6877−6887. W. Jiang#, Z. Shen#, Z. Guo#, Q. Wang, Q. Li, J. Hu, * and Y. C. Wang*. Overcoming oxygen heterogeneity of tumor microenvironments to boost cancer immunotherapy by oxygen-switchable ROS/RNS nanogenerators, Nano Today 2022, DOI:10.1016/j.nantod.2022.101696. W. Jiang,# W. Dong,# M. Li,# Z. Guo, Q. Wang, Y. Liu, Y. Bi, H. Zhou, Y. C. Wang*. Nitric Oxide Induces Immunogenic Cell Death and Potentiates Cancer Immunotherapy. ACS Nano 2022, 16, 3881-3894. [1] S. Li, Q. Wang, Y. Shen, M. Hassan, J. Shen, W. Jiang, Y. Su, J. Chen, L. Bai, W. C. Zhou, Y. C. Wang.* Pseudoneutrophil Cytokine Sponges Disrupt Myeloid Expansion and Tumor Trafficking to Improve Cancer Immunotherapy. Nano Letters, 2019, in press. [2] Y.Ma,#Y. Zhang,#;X. Li,#Y. Zhao, M. Li, W. Jiang, X. Tang, J. Dou, L. Lu, F. Wang,* Y. C. Wang.* Near-Infrared II Phototherapy Induces Deep Tissue Immunogenic Cell Death and Potentiates Cancer Immunotherapy. ACS Nano, 2019, 13, 11967-11980. [3] Y. Ma,# Y. Zhao,#N. K. Bejjanki,# X. Tang, W. Jiang, J. Dou, M. I. Khan, Q. Wang, J. Xia, H. Liu, Y. You, G. Zhang, Y. C. Wang,* J. Wang.Nanoclustered Cascaded Enzymes for Targeted Tumor Starvation and Deoxygenation-Activated Chemotherapy without Systemic Toxicity. ACS Nano, 2019, 13, 8890-8902. [4] P. Chen,#Y. Ma,# Z. Zheng,#C. Wu, Y. C. Wang,* G. L. Liang,* Facile Syntheses of Conjugated Polymers for Photothermal Tumour Therapy. Nature Communications, 2019, 10:1192. [5] Y. Zhang,#Y. Zhao,#J. Shen,# X. Sun, Y. Liu, L. Hang, H. Liu, Y. C. Wang,* J. Wang &Nanoenabled Modulation of Acidic Tumor Microenvironment Reverses Anergy of Infiltrating T Cells and Potentiates Anti-PD-1 Therapy. Nano Letters, 2019, 19, 2774-2783. [6] W.Jiang,#;Z. Zhang,# Q. Wang,# J. Dou, Y. Zhao, Y. Ma, H. Liu, H. X. Xu,* Y. C. Wang.* Tumor Reoxygenation and Blood Perfusion Enhanced Photodynamic Therapy using Ultrathin Graphdiyne Oxide Nanosheets.Nano Letters, 2019, 19, 4060-4067. [7] Y. Liu,# N. K. Bejjanki,# W. Jiang, Y. Zhao, L. Wang, X. Sun, X. Tang, H. Liu,* Y. C. Wang.* Controlled Syntheses of Well-Defined Poly(thionophosphoester)s that Undergo Peroxide-Triggered Degradation. Macromolecules, 2019, 52, 4306-4316. [8] H. Wang, Y. Hou, Y. Hu, J. Dou, Y. Shen, Y. C. Wang,* H. Lu.* Enzyme-Activatable Interferon-Poly(α-amino acid) Conjugates for Tumor Microenvironment Potentiation. Biomacromolecules,2019, 20, 3000-3008. [9] L Yang, X Chen, L Wang, Z Hu, N Xin, M Hippler, W Zhu, Y Hu, J Li, Y. C. Wang, L Zhang, D Wu, J Chu. Targeted Single-Cell Therapeutics with Magnetic Tubular Micromotor by One-Step Exposure of Structured Femtosecond Optical Vortices. Advanced Functional Materials, 2019, in press. [10]W. Huang, X. Zhang, B. Chen, H. Miao, C. O. Trindle, Y. C. Wang, Y. Luo, G. Zhang.* Boosting the Triplet Activity of Heavy-Atom-Free Difluoroboron Dibenzoylmethane viasp3 Oxygen-Bridged Electron Donors. Chemical Communications, 2019, 55, 67-70

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