Zhang, Siyuan - University of Notre Dame

个人简介

Assistant Professor, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 2012-Present Adjunct Assistant Professor, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 2012-Present Instructor, Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 2011-2012 Postdoctoral Fellow, Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 2007-2011 Research Associate, Department of Community, Occupational and Family Medicine National University of Singapore, Republic of Singapore 2005-2006 Ph.D., Cancer Biology, National University of Singapore, Singapore 2001-2005 M.D., Medicine, Peking University, Beijing, China 1993-1998

研究领域

Cancer Cellular & Molecular Biology Genetics & Genomics Neuroscience & Behavior

近期论文

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Schnepp, P.M.g, Lee, D. u, Guldner, I.H. g, Palakurthi, B. g, Eckert, K.E. u, Toni, T.A. u, Ashfeld, B.L., Zhang, S. (2017). Brain Metastatic Microenvironment Reshapes Cancer Cell Metabolism through Epigenetic Up-Regulation of Glutamate Decarboxylase 1, Cancer Res. (accepted) Casey, J., Yue, X., Nguyen, D., Acun, A., Zellmer, V., Zhang, S., Zorlutuna, P (2017). 3D Hydrogel-Based Microwell Arrays As A Tumor Microenvironment Model To Study Breast Cancer Growth. Biomedical Materials (accepted) Zellmer, V.R. g, Schnepp, P.M. g, Fracci S. u, Tan, X. p, Howe E.N. p, and Zhang, S., (2017) Tumor-induced stromal STAT1 signaling deregulates the mammary gland stem cell niche and accelerates breast cancer development, Mol. Cancer Res. (accepted) Yang, L., Zhang, Y., Guldner, I.H. g, Zhang, S., Chen, D.Z. (2016). 3D Segmentation of Glial Cells Using Fully Convolutional Networks and k-Terminal Cut. To be published in Proc. of the 19th International Conference on Medical Image Computing and Computer-Assisted Intervention – MICCAI, October 17-21, 2016. Guldner, I.H. g, Yang, L., Cowdrick, K.R. u, Wang, Q., Alvarez Barrios, W.V. g, Zellmer, V.R. g, Zhang, Y., Host, M., Liu, F., Chen, D.Z., Zhang, S. (2016). An Integrative Platform for Three-dimensional Quantitative Analysis of Spatially Heterogeneous Metastasis Landscapes. Sci Rep. Apr 12;6:24201. [IF: 5.578] Narciso, C., Cowdrick, K.R. u, Zellmer, V.R. g, Brito-Robinson, T., Brodskiy, P., Hoelzle, D.J., Zhang, S. *, Zartman J.* (2016), On-chip three-dimensional tissue histology for microbiopsies. Biomicrofluidics, v.10, 2016, p. 021101. [IF:3.357] (* co-corresponding authors) Mason, J.A., Davison-Versagli, C.A., Leliaert, A.K., Pape, D.J., McCallister, C, Zuo, J, Durbin, S.M., Buchheit, C.L., Zhang, S., Schafer Z.T. (2016). Oncogenic Ras differentially regulates metabolism and anoikis in extracellular matrix-detached cells Cell Death and Differentiation. Aug;23(8):1271-82. [IF: 8.184] Lake, M., Lake, M., Narciso, C., Cowdrick, K.R. u, Storey, T., Zhang, S., Zartman, J., and Hoelzle, D. (2015). Microfluidic device design, fabrication, and testing protocols. Protoc. Exch. DOI 10.1038/protex.2015.069 Khan, A., Zhang, S., Vigil, G., Boerckel, J., Howard, S. (2015). Two-Photon Intravital Imaging of a Mouse Brain In Vivo Using Easily Prepared Ruthenium-Poloxamer Nanoprobes in Optics in the Life Sciences, OSA Technical Digest (online) (Optical Society of America, 2015), paper BT1A.3. Yang, L. , Zhang, Y., Guldner, I.H. g, Zhang, S., and Chen, D.Z. (2015). Fast Background Removal in 3D Fluorescence Microscopy Images Using One-Class Learning. In Medical Image Computing and Computer-Assisted Intervention – MICCAI 2015, N. Navab, J. Hornegger, W.M. Wells, and A.F. Frangi, eds. (Springer International Publishing), pp. 292–299. Rayavarapu, R.R., Heiden, B., Pagani, N., Shaw, M.M., Shuff, S., Zhang, S., and Schafer, Z.T. (2015). The role of multicellular aggregation in the survival of ErbB2-positive breast cancer cells during extracellular matrix detachment. J. Biol. Chem. 290, 8722–8733. [IF: 4.6] Zhang L*, Zhang S*, Yao J, Lowery FJ, Zhang Q, Huang WC, Li P, Li M, Wang X, Zhang C, Wang H, Ellis K, Cheerathodi M, McCarty JH, Palmieri D, Saunus J, Lakhani S, Huang S, Sahin AA, Aldape KD, Steeg PS, Yu D. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. (2015) Nature. 2015 Oct 19. doi: 10.1038/nature15376. [Epub ahead of print] (*co-first author) Guldner, I.H., Zhang, S.. A Journey to Uncharted Territory: New Technical Frontiers in Studying Tumor-Stromal Cell Interactions. (2015) Integrative Biology 7(2):153-61.