D'Souza-Schorey , Crislyn - University of Notre Dame

个人简介

Department Chair, Biological Sciences, University of Notre Dame, IN 2014-Present Professor, Department of Biological Sciences, University of Notre Dame, IN 2011-Present Associate Professor, Department of Biological Sciences, University of Notre Dame, IN 2004-2011 Assistant Professor, Department of Biological Sciences, University of Notre Dame, IN 1998-2004 Research Assistant Professor, Department of Cell Biology, Washington University School of Medicine, St. Louis, MO 1997-1998 Postdoctoral Fellow, Department of Cell Biology, Washington University School of Medicine, St. Louis, MO 1993-1996 Ph.D. University of Texas Health Science Center at San Antonio, TX 1992

研究领域

Cancer Cellular & Molecular Biology Development & Regeneration

近期论文

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Clancy JW, Sedgwick A, Rosse C, Muralidharan-Chari V, Raposo G, Method M, Chavrier P, D'Souza-Schorey C. (2015) Regulated delivery of molecular cargo to invasive tumour-derived microvesicles. Nature Commun. 6: 6919-6930. Sedgwick AE, Clancy JW, Olivia Balmert M, D'Souza-Schorey C. (2015) Extracellular microvesicles and invadopodia mediate non-overlapping modes of tumor cell invasion. Scientific Reports. 5:14748. doi: 10.1038/srep14748. Pellon-Cardenas O, Clancy J, Uwimpuhwe H, D'Souza-Schorey C. (2013) ARF6-Regulated Endocytosis of Growth Factor Receptors Links Cadherin-Based Adhesion to Canonical Wnt Signaling in Epithelia. Mol. Cell. Biol. 33:2963-2975. Grossmann AH, Yoo JH, Clancy J, Sorensen LK, Sedgwick A, Tong Z, Ostanin K, Rogers A, Grossmann KF, Tripp SR, Thomas KR, D'Souza-Schorey C, Odelberg SJ, Li DY. (2013) The small GTPase ARF6 stimulates β-catenin transcriptional activity during WNT5A-mediated melanoma invasion and metastasis. Science Signaling. 6(265):ra14. doi: 10.1126/scisignal.2003398. D'Souza-Schorey C, Clancy JW. (2012) Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers. Genes and Development. 26: 1287-99. Tushir J.S., Clancy J., Warren A., Wrobel C., Brugge J.S., D'Souza-Schorey C. (2010) Unregulated ARF6 activation in epithelial cysts generates hyperactive signaling endosomes and disrupts morphogenesis. Mol. Biol. Cell. 21: 2355-2366. Muralidharan-Chari, V., Clancy J.W., Plou C., Romao M., Chavrier P, Raposo G., and D'Souza-Schorey C. (2009) “ARF6 regulated shedding of tumor-derived plasma membrane microvesicles.” Current Biology 19(22):1875-85. Muralidharan-Chari V., Hoover H., Clancy J., Schweitzer J., Suckow M., Schroeder V., Castellino F., Schorey J., D’Souza-Schorey C. (2009) ADP-ribosylation factor 6 regulates tumorigenic and invasive properties in vivo. Cancer Research 69: 2201-2209. Tushir, J.S. and D’Souza-Schorey C. (2007) ARF6-dependent activation of ERK and Rac1 modulates epithelial tubule development. EMBO J. 26: 1806-1819. D’Souza-Schorey C and Chavrier P. (2006) ARF proteins: roles in membrane traffic and beyond. Nature Reviews Mol. Cell. Biol. 7: 347-358. Palacios F., Schweitzer J., Boshans R.L. and D’Souza-Schorey, C. (2002) ARF6-GTP recruits nm23-H1 to facilitate dynamin-dependent endocytosis during adherens junction disassembly. Nature Cell Biology 4: 929-936. Van Aelst L. and D’Souza-Schorey C. (1997) Rho GTPases and signaling networks. Genes and Development 11: 2295-2322. D’Souza-Schorey C., Li G., Colombo M.I., and Stahl P.D. (1995) A regulatory role for ARF6 in receptor-mediated endocytosis. Science 267: 1175-1178.