Champion , Patricia - University of Notre Dame

个人简介

Associate Professor, University of Notre Dame, IN 2015-Present Assistant Professor, University of Notre Dame, IN 2009-2015 Postdoctoral Fellow, University of California San Francisco, CA 2003-2009 PhD. in Molecular Biology, Princeton University, NJ 2003 B.S. in Biological Sciences, Carnegie Mellon University, PA 1998

研究领域

Cellular & Molecular Biology Genetics & Genomics Infectious & Vector-Born Diseases Microbiology & Immunology

近期论文

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Williams EA, Mba Medie F, Bosserman RE, Johnson BK, Reyna C, Ferrell MJ, Champion MM, Abramovitch RB, Champion PA. A Nonsense Mutation in Mycobacterium marinum That Is Suppressible by a Novel Mechanism. Infect Immun. 2017 Jan 26;85(2). Reyna C, Mba Medie F, Champion MM, Champion PA. Rational engineering of a virulence gene from Mycobacterium tuberculosis facilitates proteomic analysis of a natural protein N-terminus. Sci Rep. 2016 Sep 14;6:33265. Johnson BK, Colvin CJ, Needle DB, Mba Medie F, Champion PA, Abramovitch RB. The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence.Antimicrob Agents Chemother. 2015 Aug;59(8):4436-45. Zhao Y, Riley NM, Sun L, Hebert AS, Yan X, Westphall MS, Rush MJ, Zhu G, Champion MM, Mba Medie F, Champion PA, Coon JJ, Dovichi NJ. Coupling capillary zone electrophoresis with electron transfer dissociation and activated ion electron transfer dissociation for top-down proteomics. Anal Chem. 2015;87(10):5422-9. Mba Medie F, Champion MM, Williams EA, Champion PA. 2014. Homeostasis of N- -terminal acetylation of EsxA correlates with virulence in Mycobacterium marinum. Infection and Immunity. Nov;82(11):4572-86 Champion MM, Williams EA, Pinapati RS, Champion PA. 2014. Correlation of phenotypic profiles using targeted proteomics identifies Esx-1 substrates. J Proteome Research. Nov 7;13(11):5151-64. Kennedy GM, Hooley GC, Champion MM, Mba Medie F, Champion PA. 2014. A novel Esx-1 locus reveals that surface-associates Esx-1 substrates mediate virulence in Mycobacterium marinum. J Bacteriology. May;196(10):1877-88. Champion PA. 2013. Disconnecting in vitro Esx-1 secretion from mycobacterial virulence. J. Bacteriol. Dec;195(24):5418-20. Champion MM, Williams EA, Kennedy GM, Champion PA. 2012. Direct detection of bacterial protein secretion using whole colony proteomics. Mol Cell Proteomics. Sep;11(9):596-604. Kennedy GM, Morisaki JH, Champion PA. 2012. Conserved mechanisms of Mycobacterium marinum pathogenesis within the environmental amoeba Acanthamoeba castellanii. Appl Environ Microbiology. 2012 Mar;78(6):2049-52.