Kuhn, Richard - Purdue University - Department of Biological Sciences

个人简介

Ph.D. SUNY at Stony Brook, 1986

近期论文

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Patkar, C. G., Larsen, M., Owston, M., Smith, J. L., Kuhn, R. J. 2009. Identification of inhibitors of yellow fever virus replication using a replicon-based high-throughput assay. Antimicrob. Agents Chemother. 53: 4103-4114. Jose, J., Snyder, J. E., Kuhn, R. J. 2009. A structural and functional perspective of alphavirus replication and assembly. Future Microbiol 4: 837:856. Cherrier, M. V., Kaufmann, B., Nybakken, G. E., Lok, S-M., Warren, J. T., Chen, B. R., Nelson, C. A., Kostyuchenko, V. A., Holdaway, H. A., Chipman, P. R., Kuhn, R. J., Diamond, M. S., Rossmann, M. G., Fremont, D. H. 2009. Structural basis for the preferential recognition of immature flaviviruses by a fusion-loop antibody. EMBO J. 28: 3269-3276. Bhattacharya, D., Mayuri, S.M. Best, R. Perera, R.J. Kuhn, R. Striker. 2009. Protein kinase G phosphorylates mosquito-borne flavivirus NS5. J. Virol. 83: 9195-9205. view article Chang, W. S., Shang, H., Perera, R. M., Lok, S. M., Sedlak, D., Kuhn, R. J., Lee, G. U. 2008. Rapid detection of dengue virus in serum using magnetic separation and fluorescence detection. Analyst. 133: 233-240. view article Perera, R., Khaliq, M., Kuhn, R. J. 2008. Closing the door on flaviviruses: Entry as a target for antiviral drug design. Antiviral Res. 80: 11-22. view article Yu, I. M., Zhang, W., Holdaway, H. A., Li, L., Kostyuchenko, V. A., Chipman, P. R., Kuhn, R. J., Rossmann, M. G., Chen, J. 2008. Structure of the immature dengue virus at low pH primes proteolytic maturation. Science. 319: 1834-1837. view article Lok, S. M., Kostyuchenko, V., Nybakken, G. E., Holdaway, H. A., Battisti, A. J., Sukupolvi-Petty, S., Sedlak, D., Fremont, D. H., Chipman, P. R., Roehrig, J. T., Diamond, M. S., Kuhn, R. J., Rossmann, M. G. 2008. Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins. Nat Struct Mol Biol. 15: 312-317. view article Patkar, C. G., Kuhn, R. J. 2008. Yellow fever virus NS3 plays an essential role in virus assembly independent of its known enzymatic functions. J Virol. 82: 3342-3352. view article Warrier, R., Linger, B. R., Golden, B. L., Kuhn, R. J. 2008. Role of Sindbis Virus Capsid Protein Region Ii in Nucleocapsid Core Assembly and Encapsidation of Genomic Rna. J Virol. 82: 4461-4470. view article Mayuri, Geders, T. W., Smith, J. L., Kuhn, R. J. 2008. Role for conserved residues of sindbis virus nonstructural protein 2 methyltransferase-like domain in regulation of minus-strand synthesis and development of cytopathic infection. J Virol. 82: 7284-7297. view article Li, L., Lok, S. M., Yu, I. M., Zhang, Y., Kuhn, R. J., Chen, J., Rossmann, M. G. 2008. The flavivirus precursor membrane-envelope protein complex: structure and maturation. Science. 319: 1830-1834. view article Perera, R., Kuhn, R. J. 2008. Structural proteomics of dengue virus. Curr. Opin. Microbiol. 11: 369-377. Bera, A. K., Kuhn, R. J., Smith, J. L. 2007. Functional characterization of cis and trans activity of the Flavivirus NS2B-NS3 protease. J Biol Chem. 282: 12883-12892. view article Boudko, S. P., Kuhn, R. J., Rossmann, M. G. 2007. The coiled-coil domain structure of the Sin Nombre virus nucleocapsid protein. J Mol Biol. 366: 1538-1544. view article Kim, H. Y., Kuhn, R. J., Patkar, C., Warrier, R., Cushman, M. 2007. Synthesis of dioxane-based antiviral agents and evaluation of their biological activities as inhibitors of Sindbis virus replication. Bioorg Med Chem. 15: 2667-2679. view article Navaratnarajah, C. K., Kuhn, R. J. 2007. Functional characterization of the Sindbis virus E2 glycoprotein by transposon linker-insertion mutagenesis. Virology. 363: 134-147. view article Patkar, C. G., Jones, C. T., Chang, Y. H., Warrier, R., Kuhn, R. J. 2007. Functional requirements of the yellow fever virus capsid protein. J Virol. 81: 6471-6481. view article van der Schaar, H. M., Rust, M. J., Waarts, B. L., van der Ende-Metselaar, H., Kuhn, R. J., Wilschut, J., Zhuang, X., Smit, J. M. 2007. Characterization of the early events in dengue virus cell entry by biochemical assays and single-virus tracking. J Virol. 81: 12019-12028. view article Zhang, Y., Kaufmann, B., Chipman, P. R., Kuhn, R. J., Rossmann, M. G. 2007. Structure of immature West Nile virus. J Virol. 81: 6141-6145. view article Hong, E. M., Perera, R., Kuhn, R. J. 2006. Alphavirus capsid protein helix I controls a checkpoint in nucleocapsid core assembly. J Virol. 80: 8848-8855. view article Kaufmann, B., Nybakken, G. E., Chipman, P. R., Zhang, W., Diamond, M. S., Fremont, D. H., Kuhn, R. J., Rossmann, M. G. 2006. West Nile virus in complex with the Fab fragment of a neutralizing monoclonal antibody. Proc Natl Acad Sci U S A. 103: 12400-12404. view article Mukhopadhyay, S., Zhang, W., Gabler, S., Chipman, P. R., Strauss, E. G., Strauss, J. H., Baker, T. S., Kuhn, R. J., Rossmann, M. G. 2006. Mapping the structure and function of the E1 and E2 glycoproteins in alphaviruses. Structure. 14: 63-73. view article Patkar, C. G., Kuhn, R. J. 2006. Development of novel antivirals against flaviviruses. Novartis Found Symp. 277: 41-52 discussion 52-46, 71-43, 251-253. Pokidysheva, E., Zhang, Y., Battisti, A. J., Bator-Kelly, C. M., Chipman, P. R., Xiao, C., Gregorio, G. G., Hendrickson, W. A., Kuhn, R. J., Rossmann, M. G. 2006. Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN. Cell. 124: 485-493. view article