Konieczny, Stephen - Purdue University - Department of Biological Sciences

个人简介

B.S., University Massachusetts, Amherst, 1977 Ph.D., Brown, 1982

近期论文

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Lo, H.-Y.G., Jin, R.U., Sibbel, G., Liu, D., Karki, A., Joens, M.S., Madison, B.B., Zhang, B., Blanc, V., Fitzpatrick, J.A.J., Davidson, N.O., Konieczny, S.F., and Mills, J.C. 2017. A single transcription factor is sufficient to induce and maintain secretory cell architecture. Genes Dev. 31:154-171. Li, J., Gu, D., Lee, S.S.-Y., Song, B., Bandyopadhyay, S., Chen, S., Konieczny, S.F., Ratliff, T.L., Liu, X., Xie, J., and Cheng, J.-X. 2016. Abrogating Cholesterol Esterification Suppresses Growth and Metastasis of Pancreatic Cancer. Oncogene 35:6378-6388. Han, B., Qu, C., Park, K., Konieczny, S.F., and Korc, M. 2016. Recapitulation of Complex Transport and Action of Drugs at the Tumor Microenvironment Using Tumor-Micorenvironment-on-Chip. Cancer Lett. 380:319-329. Hess, D.A., Strelau, K.M., Karki, A., Jiang, M., Azevedo-Pouly, A., Lee, A-H., Deering, T.G., Hoang, C.Q., MacDondald, R.J., and Konieczny, S.F. 2016. MIST1 Links Secretion and Stress as both Target and Regulator of the Unfolded Protein Response. Mol Cell Biol. 36:2931-2944. Jiang, M., Azevedo-Pouly, A.C., Deering, T.G., Hoang, C.Q., DiRenzo, D., Hess, D.A., Konieczny, S.F., Swift, G.H., MacDonald, R.J. 2016. MIST1 and PTF1 Collaborate in Feed-Forward Regulatory Loops That Maintain the Pancreatic Acinar Phenotype in Adulty Mice. Mol Cell Biol. 36:2945-2955. Liu, X., Pitarresi, J.R., Cuiti?o, M.C., Kladney, R.D., Woelke, S.A., Sizemore, G.M., Nayak, S.G., Egriboz, O., Schweickert, P.G., Yu, L., Trela, S., Schilling, D.J., Halloran, S.K., Li, M., Dutta, S., Fernandez, S.A., Rosol, T.J., Lesinski, G.B., Shakya, R., Ludwig, T., Konieczny, S.F., Leone, G., Wu, J., and Ostrowski, M.C. 2016. Genetic Ablation of Smoothened in Pancreatic Fibroblasts Increases Acinar-ductal Metaplasia. Genes Dev. 30:1943-1955. Pitarresi, J.R., Liu, X., Sharma, S.M., Cuiti?o, Kladney, R.D., Mace, T.A., Donohue, S., Nayak, S.G., Qu, C., Lee, J., Woelke, S.A., Trela, S., LaPak, K., Yu, L., McElroy, J., Rosol, T.J., Shakya, R., Ludwig, L., Lesinski, G.B., Fernandez, S.A., Konieczny, S.F., Leone, G., Wu, J., and Ostrowski, M.C. 2016. Neoplasia 18:541-552. Bi, P., Yue, F., Karki, A., Castro, B., Wirbisky, S.E., Wang, C., Durkes, A., Elzey, B.D., Andrisani, O.M., Bidwell, C.A., Freeman, J.L., Konieczny, S.F., and Kuang, S. 2016. Notch Activation Drives Adipocyte Dedifferentiation and Tumorigenic Transformation in Mice. J. Exp. Med. 213:2019-2037. Li, J., Wang, R., Schweickert, P.G., Karki, A., Yang, Y., Kong, Y., Ahmad, N., Konieczny, S.F., and Liu, X. 2016. Plk1 Inhibition Enhances the Efficacy of Gemcitabine in Human Pancreatic Cancer. Cell Cycle 15:711-719. DOI: 10.1080/15384101.2016.1148838. Karki, A., Humphrey, S.E., Steele, R.E., Hess, D.A., Taparowsky, E.A., and Konieczny, S.F. 2015. Silencing Mist1 Gene Expression Is Essential for Recovery from Acute Pancreatitis. PLoS One 10(12):e0145724. DOI:10.1371/journal.pone.0145724.view article Zhou, Z., Yang, Y., Konieczny, S.F., and Irudayaraj, J.M.K. 2015. Rapid and Unbiased Exraction of Chromatin Associated RNAs from Purified Native Chromatin. J. Chromatogr. A 1426:64-68.view article Hayakawa, Y., Ariyama, H., Stancikova, J., Sakitani, K., Asfaha, S., Renz, B.W., Dubeykovskaya, Z.A., Shibata, W., Wang, H., Westphalen, C.B., Chen, X., Takemoto, Y., Kim, W., Khurana, S.S., Tailor, Y., Nagar, K., Tomita, H., Hara, A., Sepulveda, A.R., Setlik, W., Gershon, M.D., Saha, S., Ding, L., Shen, Z., Fox, J.G., Friedman, R.A., Konieczny, S.F., Worthley, D.L., Korinek, V., and Wang, T.C. 2015. Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche. Cancer Cell 28:800-814.view article Li, J., Karki, A., Hodges, K.B., Ahmad, N., Zoubeidi, A., Strebhard, K., Ratliff, T.L., Konieczny, S.F., and Liu, X. 2015. Cotargeting Polo-Like Kinase 1 and the Wnt/β-Catenin Signaling Pathway in Castration-Resistant Prostate Cancer. Mol. Cell. Biol. 35:4185-4198.view article Kim, S.W., Lahmy, R., Riha, C., Yang, C., Jakubison, B., van Niekerk, J., Staub, C., Wu, Y., Gates, K., Dong, D.S., Konieczny, S.F., and Itkin-Ansari, P. 2015. The Basic Helix-Loop-Helix Transcription Factor E47 Reprograms Human Pancreatic Cancer Cells to a Quiescent Acinar State with Reduced Tumorigenic Potential. Pancreas 44:718-727.view article Aure, M.H., Konieczny, S.F., and Ovitt, C.E. 2015. Salivary Gland Homeostasis Is Maintained through Acinar Cell Self-Duplication. Dev. Cell 33:231-237.view article Li, Z., Li, J., Bi, P., Lu, Y., Burcham, G., Elzey, B.D., Ratliff, T., Konieczny, S.F., Ahmad, N., Kuang, S., and Liu, X. 2014. Plk1 Phosphorylation of PTEN Causes a Tumor-Promoting Metabolic State. Mol. Cell Biol. 34:3642-3661.view article Hess, D.A., Strelau, K.M., Karki, A., Jiang, M., Azevedo-Pouly, A.C., Lee, A.H., Deering, T.G., Hoang, C.Q., MacDonald, R.J., Konieczny, S.F. 2016. MIST1 Links Secretion and Stress as both Target and Regulator of the Unfolded Protein Response. Mol. Cell Biol. 36:2931-2944.