Ziarek, Joshua - Indiana University - Department of Biology

个人简介

B.S., University of Wisconsin-Milwaukee, 2007 Ph.D., Medical College of Wisconsin, 2011 Postdoctoral Training, Harvard Medical School, 2012-2017

研究领域

deciphering the conformational dynamics of GPCR activation using biophysical; biochemical and cell-based approaches

近期论文

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Ziarek, J.J., Kleist, A.B, London, N., Raveh, B., Montpas, N., Bonneterre, J., St-Onge, G., DiCosmo-Ponticello, C.J., Koplinski, C.A., Roy, I., Stephens, B., Thelen, S., Veldkamp, C.T., Coffman, F.D., Cohen, M.C., Dwinell, M.B., Thelen, M., Peterson, F.C., Heveker, N. & Volkman, B.F. 2017. Structural basis for chemokine recognition of a G protein-coupled receptor and implications for receptor activation. Science Signaling, 10:eaah5756. Wommack, A.J., Ziarek, J.J., Tomaras, J., Chileveru, H.R., Zhang, Y., Wagner, G. & Nolan, E.M. 2014. Discovery and characterization of a disulfide-locked C2-symmetric defensin peptide. Journal of the American Chemical Society, 136(39):13494-13497. Ziarek, J.J.*, Getschman, A.E.*, Butler, S.J., Taleski, D., Stephens, B., Kufareva, I., Handel, T.M., Payne, R.J. & Volkman, B.F. 2013. Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery. ACS Chemical Biology, 8:1955-1963. *Equal contributors. Ziarek, J.J., Veldkamp, C.T., Zhang, F. Murray, N.J., Kartz, G.A., Liang, X., Su, J., Baker, J.E., Lindhardt, R.J. & Volkman, B.F. 2013. Heparin Oligosaccharides Inhibit Chemokine (CXC Motif) Ligand 12 (CXCL12) Cardioprotection by Binding Orthogonal to the Dimerization Interface, Promoting Oligomerization, and Competing with the Chemokine (CXC Motif) Receptor 4 (CXCR4) N Terminus. Journal of Biological Chemistry, 288:737-746. Mysinger, M.M.*, Weiss, D.R.*, Ziarek, J.J.*, Gravel, S., Doak, A.K., Karpiak, J., Heveker, N., Shoichet, B.K. & Volkman, B.F. 2012. Structure-based ligand discovery for chemokine receptor CXCR4. Proceedings of the National Academy of Sciences of the United States of America, 109: 5517-5522.*Equal contributors. Drury, L.D.*, Ziarek, J.J.*, Gravel, S., Veldkamp, C.T., Takekoshi, T., Hwang, S.T., Heveker, N., Volkman, B.F. & Dwinell, M.B. 2011. Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways. Proceedings of the National Academy of Sciences of the United States of America, 108: 17655-17660. *Equal contributors. Veldkamp, C.T., Ziarek, J.J., Peterson, F.C., Chen, Y. & Volkman, B.F. 2010. Targeting SDF-1/CXCL12 with a ligand that prevents activation of CXCR4 through structure based drug design. Journal of the American Chemical Society, 132: 7242-7243.