个人简介

Ph.D. Emory University 1984; B.S. University of West Florida 1980

研究领域

Structural Biology

Our research efforts are aimed at understanding how retroviruses assemble and how they specifically recognized and package their genetic material. Over the past decade or so, we and others have determined the 3D structures of several isolated protein components that make up HIV-1 (the retrovirus that causes AIDS). We now wish to understand how these components interact with each other and with cellular constituents. We are also interested in understanding how these intermolecular interactions change when the initially-formed retrovirus matures and become infectious. In the long term, we would like to use the basic structural and functional information obtained to design new therapeutic approaches for the treatment of AIDS and other human diseases caused by retroviruses.

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Kyere, S.K., Joseph, P.R.B., Summers, M.F. “The p12 Domain Is Unstructured in a Murine Leukemia Virus p12-CAN Gag Construct,” PLoS ONE 3, e1902 (2008). Saad, J. S., Ablan, S. D., Ghanam, R. H., Kim, A., Andrews, K. A., Nagashima, K., Soheilian, F., Freed, A. O., Summers, M. F., “Structure of the myristylated human immunodeficiency virus type 2 matrix protein and the role of phosphatidylinositol-(4,5)-bisphosphate in membrane targeting,” J. Mol. Biol. 382, 434-447 (2008). Spriggs, S., Garyu, L., Connor, R., Summers, M. F., "Potential intra- and intermolecular interactions involving the Unique-5' Region of the HIV-1 5'-UTR," Biochemistry 46, 13064-13073 (2008). Hamard-Peron, E., Julliard, F., Saad, J. S., Roy, C., Roingeard, P., Summers, M. F., Darlix, J. L., Picart, C., Muriax, D., "Targeting of Murine Leukemia Virus Gag to the plasma membrane is mediated by PI(4,5)P2/PS and a polybasic region in the Matrix," J. Virol. 84, 503-515 (2010). Lu, K., Miyazaki, Y., Summers, M. F. “Isotope Labeling Strategies for NMR studies of RNA,” J. Biomol. NMR 46, 113-125 (2010). Miyazaki, Y., Garcia, E., King, S., Iyalla, K., Loeliger, K., Starck, P., Syed, S., Telesnitsky, A., Summers, M. F., "An RNA structural switch regulates diploid genome packaging by Moloney Murine Leukemia Virus," J. Mol. Biol. 396, 141-152 (2010). Valentine, K. G., Peterson, R., Saad, J. S., Summers, M. F., Xu, X., Ames, J. B., Wand, J. A. "Reverse micelle encapsulation of membrane anchored proteins for solution NMR studies," Structure 18, 9-16 (2010). Tolbert, B. S., Miyazaki, Y., Barton, S., Kinde, B., Starck, P., Singh, R., Bax, A., Case, D. A., Summers, M. F. “Major groove width variations in RNA structures determined by NMR and impact of 13C residual chemical shift anisotropy and 1H-13C residual dipolar coupling on refinement,” J. Biomol. NMR 47, 205-219 (2010). Laird, K. M., Briggs, L. L., Boss, J. M., Summers, M. F., Garvie, C. W. “Solution structure of the heterotrimeric complex between RFX5 and RFXAP reveals molecular details associated with MHCII gene expression,” J. Mol. Biol. 403, 40-51 (2010). Miyazaki, Y., Irobalieva, R. N., Tolbert, B., Smalls-Manty, A., Iyalla, K., Loeliger, K., D’Souza, V., Khant, H., Schmid, M. F., Garcia, E., Telesnitsky, A., Chiu, W., Summers, M. F., “Structure of a conserved retroviral RNA packaging element by NMR spectroscopy and cryo-electron tomography,” J. Mol. Biol. 404, 751-772 (2010). Summers, M. F. and Karn, J., “Structural and Molecular Biology of HIV,” J. Mol. Biol. 410, 489- 490 (2011). Lu, K., Heng, X., Summers, M. F. “Structural determinants and mechanism of HIV-1 genome packaging,” J. Mol. Biol. 410, 609-633 (2011). Lu, K., Heng, X., Garyu, L., Monti, S., Garcia, E. L., Kharytonchyk, S., Dorjsuren, B., Kulandaivel, G., Jones, S., Hiremath, A., Sachin Divakaruni, S., LaCotti, C., Barton, S., Tummillo, D., Hosic, A., Edme, K., Albrecht, S., Telesnitsky, A., Summers, M. F., “NMR detection of structures in the HIV- 1 5´-Leader RNA that regulate genome packaging,” Science 334, 242-245 (2011). Summers, M. F. “Training the next generation of Protein Scientists,” Protein Science 20, 1796- 1801 (2011). Heng, X., Kharytonchyk, S., Garcia, E. L., Lu, K., Sachin Divakaruni, S., LaCotti, C., Edme, K., Telesnitsky, A., Summers, M. F., “Identification of a Minimal Region of the HIV-1 5´-Leader required for RNA Dimerization, NC Binding and Packaging,” J. Mol. Biol. 117, 224-239 (2012). Johnson, S. F., Garcia, E. L., Summers, M. F., Telesnitsky, A. “Moloney murine leukemia virus genomic RNA packaged in the absence of a full complement of wild type nucleocapsid protein,” J. Virol. 430, 100-109 (2012). Kyere, S. K., Mercredi, P. Y., Dong, X., Spearman, P., Summers, M. F. “The HIV-1 Matrix protein does not interact directly with the protein interactive domain of AP-3 Delta,” Virus Research 169, 411-414 (2012). Yildiz, F. Z., Babalola, K., Summers, M. F. “Identification of a high affinity nucleocapsid protein binding element from the Bovine Leukemia Virus genome,” Virus Research 171, 278-286 (2012). Barton, S., Heng, X., Johnson, B., Summers, M. F. “Database proton NMR chemical shifts for RNA signal assignment and validation,” J. Biomol. NMR 55, 33-46 (2013). Checkley, M. A., Luttge, B. G., Mercredi, P. Y., Kyere, S. K., Donlan, J., Murakami, T., Summers, M. F., Cocklin, S., Freed, E. O. “Reevaluation of the requirement for TIP47 in human Immunodeficiency virus Type-1 envelope glycoprotein incorporation,” J. Virol. 87, 3561-3570 (2013).