Nolan, Elizabeth Marie - Massachusetts Institute of Technology

研究领域

Biological/Inorganic/Organic

近期论文

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Tengfei Zheng and Elizabeth M. Nolan, “Evaluation of (Acyloxy)alkyl Ester Linkers for Antibiotic Release from Siderophore-Antibiotic Conjugates,” Bioorg. Med. Chem. Lett. 2015, Accepted. (invited contribution for the 25th anniversary edition) Timothy C. Johnstone and Elizabeth M. Nolan, “Beyond Iron: Non-Classical Functions of Bacterial Siderophores,” Dalton Trans. 2015, Accepted. Haritha R. Chileveru, Shion A. Lim, Phoom Chairatana, Andrew J. Wommack, I-Ling Chiang, and Elizabeth M. Nolan, “Visualizing Attack of Escherichia coli by the Antimicrobial Peptide Human Defensin 5,” Biochemistry 2015, Just Accepted. Derek M. Gagnon, Megan Brunjes Brophy, Sarah E. J. Bowman, Troy A. Stich, Catherine L. Drennan, R. David Britt, and Elizabeth M. Nolan, “Manganese Binding Properties of Human Calprotectin Under Conditions of High and Low Calcium: X-ray Crystallographic and Advanced Electron Paramagnetic Resonance Spectroscopic Analysis,” J. Am. Chem. Soc. 2015, Just Accepted. Stephanie E. Woods, Monika R. Leonard, Joshua A. Hayden, Megan Brunjes Brophy, Kara R. Bernert, Brigitte Lavoie, Sureshkumar Muthupalani, Mark T. Wharey, Gary M. Mave, Elizabeth M. Nolan, Martin C. Carey, and James G. Fox, “Impaired Cholecystokinin-Induced Gallbladder Emptying Incriminated in Spontaneous “Black” Pigment Gallstone Formation in Germ-free Swiss Webster Mice,” Am. J. Phys. Gastrointest. Liver Pathol. 2014, accepted. Megan Brunjes Brophy and Elizabeth M. Nolan, “Manganese and Microbial Pathogenesis: Sequestration by the Mammalian Immune System and Utilization by Microorganisms,” ACS Chem. Biol. 2015, ASAP. Simone Moser, Haritha R. Chileveru, Jill Tomaras, and Elizabeth M. Nolan, “A Bacterial Mutant Library as a Tool to Study the Attack of a Defensin Peptide,” ChemBioChem 2014, 15, 2684-2688. Andrew J. Wommack, Joshua J. Ziarek, Jill Tomaras, Haritha R. Chileveru, Yunfei Zhang, Gerhard Wagner, and Elizabeth M. Nolan, “Discovery and Characterization of a Disulfide-Locked C2-Symmetric Defensin Peptide,” J. Am. Chem. Soc. 2014, 136, 13494-13497. Phoom Chairatana and Elizabeth M. Nolan, “Molecular Basis for the Self-Assembly of a Human Host-Defense Peptide that Entraps Bacterial Pathogens,” J. Am. Chem. Soc. 2014, 136, 13267-13276. Tengfei Zheng and Elizabeth M. Nolan, “Enterobactin-Mediated Delivery of Beta-Lactam Antibiotics Enhances Antibacterial Activity Against Pathogenic Escherichia coli,” J. Am. Chem. Soc. 2014, 136, 9677-9691. also, *Highlighted by Nature SciBX (July 24, 2014); *Highlighted by C&E News (June 27, 2014) Megan Brunjes Brophy, Toshiki G. Nakashige, Aleth Gaillard, and Elizabeth M. Nolan, “Contributions of the S100A9 C-Terminal Tail to High-Affinity Mn(II) Chelation by the Host-Defense Protein Human Calprotectin,” J. Am. Chem. Soc. 2013, 135, 17804-17817. Yunfei Zhang, Fabien B. L. Cougnon, Yoshitha A. Wanniarachchi, Joshua A. Hayden, and Elizabeth M. Nolan, “Reduction of Human Defensin 5 Affords a High-Affinity Zinc-Chelating Peptide,” ACS Chem. Biol. 2013, 8, 1907-1911. Joshua A. Hayden, Megan Brunjes Brophy, Lisa. S. Cunden, and Elizabeth M. Nolan, “High-Affinity Manganese Coordination by Human Calprotectin Is Calcium-Dependent and Requires the Histidine-Rich Site at the Dimer Interface,” J. Am. Chem. Soc. 2013, 135, 775-787. Andrew J. Wommack, Scott A. Robson, Yoshitha A. Wanniarachchi, Andrea Wan, Christopher J. Turner, Gerhard Wagner, and Elizabeth M. Nolan, “NMR Solution Structure and Condition-Dependent Oligomerization of the Antimicrobial Peptide Human Defensin 5,” Biochemistry 2012, 51, 9624-9637. Tengfei Zheng, Justin L. Bullock, and Elizabeth M. Nolan, “Siderophore-Mediated Cargo Delivery to the Cytoplasm of Escherichia coli and Pseudomonas aeruginosa: Syntheses of Monofunctionalized Enterobactin Platforms and Evaluation of Enterobactin-Cargo Conjugate Uptake,” J. Am. Chem. Soc. 2012, 134, 18388-18400. Megan Brunjes Brophy, Joshua A. Hayden, and Elizabeth M. Nolan, “Calcium Ion Gradients Modulate the Zinc Affinity and Antibacterial Activity of Human Calprotectin,” J. Am. Chem. Soc. 2012, 134, 18089-18100. Tengfei Zheng and Elizabeth M. Nolan, “Siderophore-Based Detection of Fe(III) and Microbial Pathogens” (review), Metallomics 2012, 24, 866-880 (invited contribution to the Emerging Investigators issue). Yoshitha A. Wanniarachchi, Piotr Kaczmarek, Andrea Wan and Elizabeth M. Nolan, “Human Defensin 5 Disulfide Array Mutants: Disulfide Bond Deletion Attenuates Antibacterial Activity against Staphylococcus aureus,” Biochemistry 2011, 50, 8005-8017. Matthias Strieker, Elizabeth M. Nolan, Christopher T. Walsh and Mohamed A. Marahiel, “Stereospecific Synthesis of threo- and erythro-β-Hydroxyglutamic Acid During Kutzneride Biosynthesis,” J. Am. Chem. Soc. 2009, 131, 13523-13530.