个人简介

Ph.D. Bowling Green State University 1993; M.S. University of Rochester 1989; B.S. State University of New York at Geneseo 1988

研究领域

Physical/Inorganic Sensors and Imaging Spectroscopy/Dynamics

Photochemical probes of macromolecular structure. Advances in genomics and proteomics require new tools in molecular biology. In our laboratory, we are developing synthetic organic and inorganic molecules as structural probes of DNA and proteins. Through molecular engineering, we synthesize the compounds to recognize and bind to specific DNA sequences or protein residues. To date, we have used naphthalimide derivatives that are readily synthesized and functionalized. Upon activation with UV or visible light, the compounds initiate a sequence of chemical events that lead to cleavage of the macromolecule at the binding site. In parallel, transient laser spectroscopy is used to understand reaction mechanisms. Once the fragments are identified using HPLC and mass spectrometry, the DNA or protein structure may be reconstructed. Thus, these ‘photonucleases’ and ‘photoproteases’ provide new tools to identify the sequence and 3D structure of DNA and proteins. Stimuli-Responsive Polymers. Stimuli-responsive polymers find broad-ranging applications in smart materials and smart packaging applications. Our group is interested in building functionalized polymers that respond, via basic photophysical phenomena, to changes in external stimuli (temperature, pressure, etc.). Fundamentally, we are interested in gaining knowledge about how the polymer architecture governs, among other things, the thermal properties of the polymer. Traditional synthetic polymer chemistry is used to systematically build and functionalize the polymers. NMR, mass spectrometry, and DSC are used to characterize the materials. Steady-state and time-resolved fluorescence methods are used to understand the fundamental photophysics. Specifically, using time-correlated single-photon counting, the polymer dynamics and rate constants for excited-state interconversions, are mapped out to understand which elementary reaction step controls the temperature-dependent photophysics. As a result, systematic structure-function correlations are obtained.

近期论文

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Manning, S. J.; Bogen, W.; Kelly, L. A. ‘Synthesis, Characterization, and Photophysical Study of of Fluorescent N-Substituted Benzo[ghi]perylene ‘Swallow Tail’ Monoimides,’ The Journal of Organic Chemistry,2011, 76, 6007-6013. Trexler, M. M.; Zhang, D.; Kelly, L.; Sample, J. ‘Crystal Structure and Optical Properties of Erbium- and Neodymium-Doped Zirconia Nanoparticles,’ Journal of Materials Research, 2010, 25, 500 – 509 Arnold, B.; Kelly, L.; Oleske, J. B.; Schill, A. ‘Standoff Detection of Nitrotoluenes Using 213-nm Amplified Spontaneous Emission from Nitric Oxide,’ Analytical and Bioanalytical Chemistry, 2009, 395, 349-355. Schill, Alexander W.; Arnold, Bradley R.; Kelly, Lisa A.; Pellegrino, Paul, M. ‘Standoff Detection using Coherent Backscattered Spectroscopy,’ Proc. of SPIE, 2007, 6554, 6554G-1 – 6554G-8. McMasters, S. and Kelly, L. A. ‘Sequence-Dependent Interactions of Cationic Naphthalimides and Polynucleotides,’ Photochemistry and Photobiology, 2007, 83, 889 – 896. McMasters, S.; Kelly, L. A. “Ground-State Interactions of Spermine-Substituted Naphthalimides with Mononucleotides,” Journal of Physical Chemistry, B, 2006, 110, 1046-1055. Kimaro, A.; Kelly, L. A.; Murray, G. M., “Synthesis and Characterization of Molecularly Imprinted Uranyl Ion Exchange Resins,” Separation Science and Technology, 2005, 40, 2035–2052. McMasters, S.; Kelly, L. A. “Ground-State Interactions of Spermine-Substituted Naphthalimides with Mononucleotides,” Journal of Physical Chemistry, B, 2006, 110, 1046-1055. Abraham, B.; McMasters S.; Mullan, M. A.; Kelly, L. A., ‘Reactivities of Carboxy-Substituted 1,4,5,8-Naphthalene Diimides in Aqueous Solution,’ Journal of the American Chemical Society, 2004, 126, 4293-4300. Chandrasekharan, N; Kelly, L. A., ‘Progress Towards Fluorescent Molecular Thermometers,’ in Reviews in Fluorescence 2004, Geddes, C. D., Editor, 2004, pgs. 21-40. Abraham, B.; Kelly, L., ‘Photo-oxidation of Amino Acids and Proteins Mediated by Novel 1,8-Naphthalimide Derivatives,’ J. Phys.Chem B 2003, 107, 12534 – 12541. Chandrasekharan, N.; Kelly, L., ‘Fluorescent Molecular Thermomemters Based on Monomer/Excimer Interconversion,’ The Spectrum 2002, 15, 1-7. Rogers, J. E.; Le, T. P.; Kelly, L. A., ‘Nucleotide Oxidation Mediated by Naphthalimide Excited States with Covalently Attached Viologen Cosensitizers,’ Photochem. Photobiol. 2001, 73, 223-229. Kimaro, A.; Kelly, L. A.; Murray, G. M., ‘Molecularly Imprinted Ionically Permeable Membrane for Uranyl Ion,’ Chemical Communications 2001, 1282 – 1283. Rogers, J. E.; Abraham, B.; Rostkowski, A.; Kelly, L. A., ‘Mechanisms of Photoinitiated Cleavage of DNA by 1,8-Naphthalimide Derivatives,’ Photochem. Photobio. 2001, 74, 521-531. Chandrasekharan, N. and Kelly, L. A. ‘A Dual Fluorescence Temperature Sensor Based on Perylene/Exciplex Interconversion,’ J. Am. Chem. Soc. 2001, 123, 9898-9899. Rogers, J. E.; Weiss, S. J.; Kelly, L. A., ‘Photoprocesses fo Naphthalene Imide and Diimide Derivatives in Aqueous Solutions of DNA,’ J. Am. Chem. Soc. 2000, 122, 427-436. Le, T. P.; Rogers, J. E.; Kelly, L. A., ‘Photoinduced Electron Transfer in Covalently Linked 1,8-Naphthalimide/Viologen Systems,’ J. Phys. Chem. A. 2000, 104, 6778-6785. Rogers, J. E.; Kelly, L. A., ‘Nucleic Acid Oxidation Mediated by Naphthlene and Benzophenone Imide and Diimide Derivatives: Consequences for DNA Redox Chemistry,’ J. Am. Chem. Soc. 1999, 121, 3854-3861. Morgana M. Trexler, Dajie Zhang, Lisa Kelly, Jennifer Sample . ‘Crystal structure and optical properties of erbium- and neodymium-doped zirconia nanoparticles’. Journal of Materials Research 25. 3 (2010)