Cho, Kyu Hong - Indiana State University

研究领域

Our research focuses on the pathogenic mechanisms of the Gram-positive human pathogen Streptococcus pyogenes. S. pyogenes, also known as Group A streptococcus (GAS), inhabits the pharyngeal mucosal surfaces of approximately 10% of the human population. This organism can cause a variety of diseases such as mild superficial infections (impetigo, pharyngitis), toxigenic diseases (scarlet fever, toxic-shock syndrome), sequelae (rheumatic heart disease, glomerulonephritis), and invasive diseases (cellulitis, necrotizing fasciitis). To the public, this pathogen is known as a “flesh eating bacterium”, because it can destroy the subcutaneous and muscle layers in or below the skin very rapidly causing necrotizing fasciitis. A recent survey estimated that severe GAS diseases including post infectious sequelae and invasive infections cause over a half million deaths each year globally. The goal of my research is 1) to identify streptococcal system conferring virulence to the bacterium, 2) to determine the molecular mechanisms of the system and 3) to develop drugs that interfere with the system as therapeutic measures.

近期论文

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Cho, K.H. & Kim, J.H. 2014. Evidence suggesting that glucose binding protects the yeast cell surface glucose sensors from endocytosis. Communicative and Integrative Biology Accepted on Aug 2014. Roy, A., Kim Y.B., Cho, K.H. & Kim, J.H. 2014. Glucose starvation-induced turnover of the yeast glucose transporter Hxt1. Biochim Biophys Acta 1840(9):2878-2885. Roy, A., Jouandot II, D., Cho, K.H. & Kim, J.H. 2014. Understanding the mechanism of glucose-induced relief of Rgt1-mediated repression in yeast. FEBS Open Bio. 4:105-111. Cho, K.H., Wright J., Svencionis, J. & Kim, J.H. 2013. The prince and the pauper. Which one is real? The problem of secondary mutation during mutagenesis in Streptococcus pyogenes. Virulence 4(8): 1-2. Cho, K.H. & Kang, S. O. 2013. Streptococcus pyogenes GdpP, the c-di-AMP phosphodiesterase, influences SpeB maturation and virulence. PLOS ONE 8(7): e69425. doi:10.1371/journal.pone.0069425. Kim, J.H., Roy, A., Jouandot, D. 2nd & Cho, K.H. 2013. The glucose-signaling network in yeast. Biochimica et Biophysica Acta. 1830(11):5204-10 Tesorero, R.A., Yu, N., Wright, J.O., Svencionis, J.P., Cheng Q., Kim, J.H. & Cho, K.H. 2013. Novel regulatory small RNAs in Streptococcus pyogenes. PLOS ONE. 8(6):e64021. doi:10.1371/Journal.pone.0064021. Roy, A., Shin Y.J., Cho, K.H. & Kim, J.H. 2013. Mth1 Regulates Expression of the Glucose Transporter Genes by Modulating the Interaction of Rgt1 with Ssn6-Tup1 in yeast. Molecular Biology of the Cell 24(9):1493-503. Kang, S.O., Tesorero, R.A., Wright, J.O., Lee, H., Beall, B. & Cho, K.H. 2012. Thermoregulation of capsule production by Streptococcus pyogenes. PLOS ONE. 7(5):e37367. Doi:10.1371/journal.pone.0037367. Kang, S.O., Caparon, M.G. & Cho, K.H. 2010. Virulence Gene regulation by CvfA, a putative RNase: the CvfA-enolase complex in Streptococcus pyogenes links nutritional stress, growth phase control and virulence gene expression. Infect Immun. 78(6):2754-67. Cho, K.H. & Caparon, M.G. 2008. tRNA modification mutants as candidate live attenuated strains of Streptococcus pyogenes. Infect Immun. 76(7):3176-86. Cho, K.H. & Caparon, M.G. 2006. Genetics of group A streptococci. In: Gram-positive pathogens (2Eds.), pages 59-73. ASM Press. Cho, K.H. & Caparon, M.G. 2005. Patterns of virulence gene expression differ between biofilm and tissue community of Streptococcus pyogenes. Mol Micro. 57(6):1545-56. Nyberg, P., Sakai, T., Cho, K.H., Caparon, M.G., Fassler, R. & Bjorck, L. 2004. Interactions with fibronectin attenuate the virulence of Streptococcus pyogenes. EMBO J. 19,23(10):2166-74. Cho, K.H. & Salyers, A.A. 2001. Biochemical analysis of interactions between outer membrane proteins that contribute to starch utilization by Bacteroides thetaiotaomicron. J. Bacteriol. 183:7224-30. Cho, K.H., Cho, D.L., Wang, G. & Salyers, A.A. 2001. New regulatory gene that contributes to control of Bacteroides thetaiotaomicron starch utilization genes. J. Bacteriol. 183:7198-205. Shipman, J.A., Cho, K.H., Siegel, H.A. & Salyers, A.A. 1999. Physiological characterization of SusG, an outer membrane protein essential for starch utilization by Bacteroides thetaiotaomicron. J. Bacteriol. 181:7206-11. Cho, K. H., Cho, Y.K., Hong, S.S. & Lee, H.S. 1995. Optimization for lactic acid production with isolated microorganisms showing high productivity. Kor. J. Appl. Microbiol. Biotechnol. 23:6-11. Cho, Y.K., Cho, K.H., Hong, S.S. & Lee, H.S. 1995. Optimization of medium components for lactic acid production. Kor. J. Appl. Microbiol. Biotechnol. 23:12-16.