个人简介

Ph.D. University of Bordeaux 1 (France) 2003; Post-Doctoral Tokyo University (Japan) 2004; Post-Doctoral Indiana University (IN) 2004

研究领域

Analytical Organic Physical/Inorganic Sensors and Imaging

Need of better delivery systems Several challenges need to be overcome in chemotherapy to markedly increase its efficacy and potency. Chief among them, multiple side effects and the occurrence of drug resistance severely compromise the efficacy of chemotherapy. Whereas several drug delivery systems exist and intense research is done on combined therapy and on tumor targeting, the simultaneous targeting of different therapeutic entities to the cancer cells is still an area of research to be developed. Nanovectors: new types of drug delivery systems Preparation of nanovectors Nanovectors represent a valid approach to fulfil this need due to their inherent high multivalency and versatility. Indeed, nanovectors are in general composed of at least three main parts: – a nanometer sized core (hollow or solid) – a therapeutic and/or imaging load and some tumor cell recognition component. The nanoscale of the nanovectors endows them with unique properties. Among them, their potential for a large cargo of similar and/or different functions and their reduced clearance time confer on them superiority over traditional drug carriers. Indeed, their dimensions make them big enough to avoid elimination by renal filtration while enabling them to bear multiple functionalities. Also, they can integrate means to bypass biological barriers. For instance, it is now well established that the use of PEG is a very good option to avoid recognition by the immune system. Nanovectors are still small enough (< 100 nm) such that the uptake by macrophages of the RES,leading to body clearance, remains minimal. Advantages of gold nanoparticles and dendrimers Gold nanoparticles (GNPs) and dendrimers have already shown great potential for therapeutic use. GNPs are biocompatible and inert. Their synthesis is easy and cheap. Their size and coating can be modulated as desired (2 to 100 nm in size). Dendrimers are synthetic polymeric molecules composed of multiple perfectly branched monomers that emanate radially from a central core, leading to a spherical shape. Due to their size (nanometer scale), their low polydispersity and their multifunctionality, dendrimers have found use as drug carriers conferring low cytotoxicity, membrane permeability and targeting capabilities. Dendrons can be described as fragments of dendrimers, being hyper-branched organic molecules with a terminal focal point allowing for attachment to a central core. In this project, the focal point is used as the site of binding to the surface of the GNPs.

近期论文

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(Pan, H.; Grow, M. E.;) Wilson, O. M. and Daniel, M.-C.* “A New PPI Dendron as Potential Convenient Building-block in Construction of Multifunctional Systems” Tetrahedron, 2013, 2799-2806. Zabetakis, K.*; Ghann, W. E.*; Kumar, S.; Daniel, M.-C. “Effect of high gold salt concentrations on the size and polydispersity of gold nanoparticles prepared by an extended Turkevich-Frens method” Gold Bulletin, 2012, 45(4), 203-211. Ghann, W. E.; Aras, O.; Fleiter, T.; Daniel M.-C. “Syntheses and Characterization of Lisinopril-Coated Gold Nanoparticles as Highly Stable Targeted CT Contrast Agents in Cardiovascular Diseases” Langmuir, 2012, 28(28), 10398-10408. Ghann, W. E.; Aras, O.; Fleiter, T.; Daniel, M.-C. “Synthesis and biological studies of highly concentrated lisinopril-capped gold nanoparticles for CT tracking of angiotensin converting enzyme (ACE)” Proc. SPIE 2011, 8025, 80250H. Pan, H.; Daniel, M.-C. “Studies of MRI relaxivities of gadolinium-labeled dendrons” Proc. SPIE 2011, 8025, 80250F. Pan, H.; Daniel, M.-C. “Gadolinium-labeled dendronized gold nanoparticles as new targeted MRI contrast agent” Proc. SPIE 2010, Vol. 7674(Smart Biomedical and Physiological Sensor Technology VII), 767404/1-767404/10. Daniel, M.-C.; Aras, O.; Smith, M. F.; Nan, A.; Fleiter, T.; “Targeted in-vivo computed tomography (CT) imaging of tissue ACE using concentrated lisinopril-capped gold nanoparticle solutions” Proc. SPIE 2010, Vol. 7674(Smart Biomedical and Physiological Sensor Technology VII), 76740J/1-76740J/9. Daniel, M.-C.; Tsvetkova, I. B.; Quinkert, Z.T.; Murali, A.; De, M.; Rotello, V. M.; Kao, C. C.; Dragnea, B. ‘Role of Surface Charge Density in Nanoparticle-Templated Assembly of Bromovirus Protein Cages.’ ACS Nano 2010, 4(7), 3853-3860. Li, Y.; Baeta, C.; Aras, O.; Daniel, M.-C. “Preparation of lisinopril-capped gold nanoparticles for molecular imaging of angiotensin-converting enzyme” Proc. SPIE 2009, Vol. 7313, 731304. Sun, J.; Dufort, C.; Daniel, M.-C.;, Murali A.; Chen, C.; Gopinath, K.; Stein, B.; De, M.; Rotello, V. M.; Holzenburg, A.; Kao, C. C.; Dragnea, B. ‘Core-controlled Polymorphism in Virus-like-Particles.’ Proceedings of the National Academy of Science of the United States of America 2006, 104(4), 1354-1359. Dixit, S. K.; Goicochea, N. L.; Daniel, M.-C.; Murali, A.; Bronstein, L.; De, M.; Stein, B.; Rotello, V. M.; Kao, C. C.; Dragnea, B. ‘Quantum Dot Encapsulation in Viral Capsids.’ Nano Letters 2006, 6, 1993-1999. Chen, C.; Daniel, M.-C.; Quinkert, Z. T.; De, M.; Stein, B.; Bowman, V. D.; Chipman, P. R.; Rotello, V. M.; Kao, C. C.; Dragnea, B. ‘Nanoparticle-Templated Assembly of Viral Protein Cages.’ Nano Letters 2006, 6, 611-616 (Astruc, D.)*; Daniel, M.-C.; Ruiz, J. “Metallodendritic exo-receptors for the redox recognition of oxo-anions and halides.” Topics in Organometallic Chemistry 2006, 20, Issue Dendrimer Catalysis, 121-148. (Ruiz, J.); Daniel, M.-C.; Astruc, D.* "Metallocenes as References for the Determination of Redox Potentials by Cyclic Voltammetry - Permethylated Iron and Cobalt Sandwich Complexes, Inhibition by Polyamine Dendrimers, and the Role of Hydroxy-containing Ferrocenes." Canadian Journal of Chemistry 2006, 84(2), 288-299. (Daniel, M.-C.); Sakamoto, A.; Ruiz, J.; Astruc, D.; Nishihara, H.* "Photoisomerization-induced Change in the Size of Ferrocenylazobenzene-attached Dendrimers." Chemistry Letters 2006, 35, 38-39. (Daniel, M.-C.); Ruiz, J.; Astruc D.* "Inhibition of the Electrochemistry of Ferrocenes by Polyamine Dendrimers and the Key Role of Hydrogen-bonding with Hydroxy Groups." Chem. Commun, 2005, 12, 1569-1571. (Méry, D.); Ornelas, C.; Ruiz, J.; Daniel, M.-C.; Rodriguez, J.; Astruc, D.; Cordier, S.; Kiraki, K.; Perrin, C.* "Mo6Br8-Cluster-cored Organometallic Stars and Dendrimers." C. R. Chimie, 2005, 8 (11-12), 1789-1797. (Daniel, M.-C.); Ba, F.; Ruiz, J.; Astruc, D.* "Assemblies of Redox-Active Metallodendrimers using Hydrogen Bonding for the Electrochemical Recognition of the H2PO4- and Adenosyl-5'-Triphosphate (ATP2-) Anions." Inorg. Chem., 2004, 43, 8649-8657. (Astruc, D.)*; Blais, J.-C.; Daniel, M.-C.; Martinez, V.; Nlate, S.; Ruiz, J. "Nanoscale Metallodendritic Complexes in Electron Transfer Processes and Catalysis." Abd-El-Aziz Ed. Kluwer, Dordrecht, Macromol. Symp., 2003, 196 , 1-25. (Astruc, D.)*; Blais, J.-C.; Daniel, M.-C.; Gatard, S.; Nlate, S.; Ruiz, J. "Metallodendrimers and Dendronized Gold Colloids as Nanocatalysts, Nanosensors and Nanomaterials for Molecular Electronics." C. R. Chimie, 2003, 6, 1117-1127.