个人简介

Ph.D. Univ. of California, Berkeley 1965; B.A. Cornell University 1961

研究领域

Biochemistry Structural Biology

High resolution NMR spectroscopy and computer molecular modeling are used to explore the conformation and dynamics of complex carbohydrates of the cell surface. Techniques such as scalar and dipolar coupling and nuclear Overhauser effects are applied to study glycoprotein oligosaccharides and the antigenic polysaccharides of pathogenic bacteria.

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

C. A. Bush, P. Patel, S. Gunawardena, J. Powell, A. Joseph, J.A. Johnson and J. G. Morris ``Classification of Vibrio vulnificus strains by the carbohydrate composition of their capsular polysaccharides'' Analyt. Biochem. 250, 186-195 (1997) Text of the paper: J. O. Cisar, A. L. Sandberg, G.P. Reddy, C. Abeygunawardana and C. A. Bush ``Structural and Antigenic Types of Cell Wall Polysaccharides from Viridans Streptococci with Receptors for Oral Actinomyces and Streptococcal Lectins'' Infection and Immunity, 65 , 5035-5041, (1997) Text of the paper. P.K. Agrawal, C. A. Bush, N. Qureshi and K. Takayama ``1H and 13C NMR Assignment of Lipopolysaccharide Obtained from Deep Rough Mutant of Escherichia coli D31m4'' Magnetic Resonance in Chemistry 36 , 1-7 (1998). Text of the paper G. Prabhakar Reddy, Unaiza Hayat, Qiuwei Xu, K. Vasavi Reddy Yuhui Wang, Kou-Wei Chiu, J. Glenn Morris,Jr. and C. Allen Bush "Structure Determination of the Capsular Polysaccharide from Vibrio vulnificus Strain 6353", European Journal of Biochem. 255, 279-288. (1998), Text of the paper: Shamantha Gunawardena, G. P. Reddy, Yuhui Wang, V.S. Kumar Kolli, Ron Orlando, J. Glenn Morris and C. Allen Bush "Structure of a Muramic Acid Containing Capsular Polysaccharide from the Pathogenic Strain of Vibrio vulnificus ATCC 27562. " Carbohydrate Research 309, 65-76 (1998) Text of the paper: --and-- Figures and Tables: Qiuwei Xu and C. Allen Bush "Measurement of Long-range Carbon-Carbon Coupling Constants in a Uniformly Enriched Complex Polysaccharide." Carbohydrate Research (1998) 306, 335-339. Text of the paper: C. Allen Bush, Manuel Martin-Pastor and Anne Imberty, ``Structure and Conformation of Complex Carbohydrates of Glycoproteins, Glycolipids and Bacterial Polysaccharides'' Annu. Rev. Biophys. and Struct. Biol. {\bf 28}, 269-293.(1999) Text of the paper: Manuel Martin-Pastor and C. Allen Bush ``A new strategy for the Conformational Analysis of Carbohydrates based on NOE and 13C NMR Coupling Constants. Application to the flexible polysaccharide of Streptococcus mitis J22'' Biochemistry 38, 8045-8055 (1999). Text of the paper: S. Gunawardena, C. R. Fiore, J. A. Johnson and C. Allen Bush ``The conformation of a rigid tetrasaccharide epitope in the capsular Polysaccharide of Vibrio cholerae O139'' Biochemistry 38,12062-12071, (1999) Text of the paper: Manuel Martin-Pastor and C. Allen Bush ``The use of NMR residual dipolar couplings in aqueous dilute liquid crystalline medium for conformational studies of complex oligosaccharides'' Carbohydr. Res. 323, 147-155 (2000) Text of the paper: Manuel Martin-Pastor and C. Allen Bush ``Conformational studies of human milk oligosaccharides using NMR residual dipolar couplings'' Biochemistry 39, 4674-4683 (2000). Text of the paper: Manuel Martin-Pastor and C. Allen Bush ``Comparison of the conformation and dynamics of a polysaccharide and of its isolated heptasaccharide repeating unit on the basis of NOE, long rnage C-C and C-H coupling constants and NMR relaxation data'' Biopolymers, 54 235-248, (2000). Text of the paper: Manuel Martin-Pastor and C. Allen Bush ``Refined structure of a flexible heptasaccharide using H1-C13 and H1-H1 NMR residual dipolar couplings in concert with NOE and long range scalar coupling constants'' J. Biomolec. NMR 19, 125-139 (2001). Text of the paper: H. F. Azurmendi, M. Martin-Pastor and C. A. Bush ``Conformational studies of Lewis X and Lewis A trisaccharides using NMR residual dipolar couplings'' (2002) Biopolymers 63, 89-98. Text of the paper: H. F. Azurmendi and C. A. Bush ``Tracking Alignment from the Moment of Inertia Tensor (TRAMITE) of Biomolecules in Neutral Dilute Liquid Crystal Solutions" (2002) J. Amer. Chem. Soc., 124, 2426-2427 Text of the paper: and Supplementary information for the paper: H. F. Azurmendi and C. A. Bush ``Conformational studies of blood group A and blood group B oligosaccharides using NMR residual dipolar couplings" (2002) Carbohydr. Res., 337,905-915. Text of the paper: Corne' J.M. Stroop, Qiuwei Xu, Mary Retzlaff, Chitranda Abeygunawardana, C. Allen Bush ``Structural analysis and chemical depolymerisation of the capsular polysaccharide of Streptococcus pneumoniae type 1'' Carbohydr. Res. 337, 334-344 (2002) Text of the paper: C. J.M. Stroop, C. A. Bush, R. L. Marple, and W. R. LaCourse ``Carbohydrate Analysis of Bacterial Polysaccharides by High-pH Anion-Exchange Chromatography and On-Line Polarimetric Determination of Absolute Configuration'' Analyt. Biochem., 303, 176-185 (2002). Text of the paper: C. Allen Bush. "Origins of Flexibility in Complex Polysaccharides" in ACS Symposium Series, Vol. 834. ``NMR Spectroscopy of Polymers in Solution and in the Solid State''. H.N. Cheng and Alan D. English, eds. pp. 272-288, American Chemical Society, Washington, D.C., 2003. Text of the paper: