个人简介

2001, B.S. Nanjing University (Nanjing, China) 2008, Ph.D. University of Illinois at Urbana-Champaign 2008-2014, Columbia University, Postdoctoral Research Scientist

研究领域

Chemistry, Biochemistry: Protein structure and dynamics by NMR spectroscopy

Our research focuses on the characterization of dynamic properties of proteins in the context of protein-protein interactions in order to understand how these properties are related to protein function. Specifically, we are interested in a group of enzymes that catalyze the detachment of ubiquitin chains from substrate proteins. Ubiquitin modification has emerged as an important post-translational modification that regulates immune responses and many other cellular processes. The goal is to understand what are the roles of time-dependent conformational properties of both the enzymes and substrates in the substrate recognition process. We use NMR spectroscopy as the main experimental technique but also combine it with other biochemical and biophysical techniques. Besides the main research direction outlined above, we also are interested in developing NMR methods to improve spectral resolution and sensitivity.

近期论文

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Rotation operator propagators for time-varying radiofrequency pulses in NMR spectroscopy: Applications to shaped pulses and pulse trains Li, Y., Rance, M., Palmer, A. G., III J. Magn. Reson. 2014, in press. Conformational Flexibility in the Binding Surface of the Potassium Channel Blocker ShK Sher, I., Chang, S. C., Li, Y., Chhabra, S., Palmer, A. G., III, Norton, R. S., Chill, J. H. Chembiochem 2014, in press. Mechanism of E-cadherin dimerization probed by NMR relaxation dispersion Li, Y., Altorelli, N. L., Bahna, F., Honig, B., Shapiro, L., Palmer, A. G., III Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 16462-16467. Narrowing of protein NMR spectral lines broadened by chemical exchange Li, Y., Palmer, A. G., III J. Am. Chem. Soc. 2010, 132, 8856-8857. TROSY-selected ZZ-exchange experiment for characterizing slow chemical exchange in large proteins Li, Y., Palmer, A. G., III J. Biomol. NMR 2009, 45, 357-360. Chemical shift assignment of the transmembrane helices of DsbB, a 20-kDa integral membrane enzyme, by 3D magic-angle spinning NMR spectroscopy Li, Y., Berthold, D. A., Gennis, R. B., Rienstra, C. M. Protein Sci. 2008, 17, 199-204. Structural analysis of nanoscale self-assembled discoidal lipid bilayers by solid-state NMR spectroscopy Li, Y., Kijac, A. Z., Sligar, S. G., Rienstra, C. M. Biophys. J. 2006, 91, 3819-3828.