Johnson, Jeremiah A. - Massachusetts Institute of Technology

个人简介

2018-current Associate Professor,Department of Chemistry Program in Polymers and Soft Matter Member, Koch Institute at MIT Massachusetts Institute of Technology 2017-2018 Firmenich Career Development Associate Professor (with Tenure),Department of Chemistry Program in Polymers and Soft Matter Member, Koch Institute at MIT Massachusetts Institute of Technology 2016-2017 Firmenich Career Development Associate Professor (w/o Tenure), Department of Chemistry and Program in Polymers and Soft Matter, Massachusetts Institute of Technology 2015-2016 Firmenich Career Development Assistant Professor, Department of Chemistry and Program in Polymers and Soft Matter, Massachusetts Institute of Technology 2011-2015 Assistant Professor,Department of Chemistry and Program in Polymers and Soft Matter,Massachusetts Institute of Technology 2009-2011 Beckman Institute Postdoctoral Scholar with Professors Robert H. Grubbs and David A. Tirrell, California Institute of Technology 2005-2007 Graduate research with Professor M.G. Finn,The Scripps Research Institute, summers 2004-2009 Graduate research with Professors Nicholas J. Turro and Jeffrey T. Koberstein,Columbia University 2001-2004 Undergraduate research with Karen L. Wooley,Washington University in St. Louis

研究领域

The Johnson laboratory seeks creative, macromolecular solutions to problems at the interface of chemistry, medicine, biology, and materials science. Materials synthesis is approached in an analogous manner to natural-products synthesis; an interesting target structure is chosen and a synthetic scheme is designed to access that structure as efficiently as possible. The targets are designed de novo from careful consideration of the specific needs of a given application and with a particular emphasis on function. The tools of traditional organic and organometallic synthesis, synthetic polymer chemistry, photochemistry, surface science, and biopolymer engineering are combined to realize the designs. Just as natural-products chemists must often invent new reaction methodologies to access complex structures and their corresponding derivatives, the Johnson lab will seek to develop new methodologies for the construction and modification of complex material libraries. Iterative library synthesis, function-based screening, and design optimization will ultimately yield basic knowledge, such as structure-function relationships for materials in specific applications, and new materials-based technologies that outperform current alternatives. Some examples of target material platforms and their associated applications are: (1) novel, nanoscopic branched-arm star polymer architectures for in vivo drug delivery and supported catalysis, (2) hybrid synthetic-natural hydrogels for correlation of the effects of network microstructure on cell response, and (3) new types of semiconducting organometallic polymers and polymer films for sensing, supported catalysis, and energy conversion.

近期论文

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“Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs.”Golder, M. R.†; Liu, J.†; Andersen, J. N.; Shipitsin, M. V.; Vohidov, F.; Nguyen, H. V.-T.; Ehrlich, D. C.; Huh, S. J.; Vangamudi, B.; Economides, K. D.; Neenan, A. M.; Ackley, J. C.; Baddour, J.; Paramasivan, S.; Brady, S. W.; Held, E. J.; Reiter, L. A.; Saucier-Sawyer, J. K.; Kopesky, P. W.; Chickering, D. E.; Blume-Jensen, P.*; Johnson, J. A.* Nat. Biomed. Eng. 2018, accepted. “Photoswitching topology in polymer networks with metal-organic cages as crosslinks.”Gu, Y.; Alt, E. A.; Wang, H.; Li, X.; Willard, A. P.; Johnson, J. A.* Nature 2018, DOI: 10.1038/s41586-018-0339-0. “Supramolecular recognition of anions enhances conductivity and transference number of lithium in liquid electrolytes.”Qiao, B.*; Leverick, G. M.; Zhao, W.; Flood, A. H.; Johnson, J. A.*; Shao-Horn, Y. J. Am. Chem. Soc. 2018, DOI: 10.1021/jacs.8b05915. “Templated self-assembly of a PS-branch-PDMS bottlebrush copolymer.”Cheng, L.; Gadelrab, K.; Kawamoto, K.; Yager, K.; Johnson, J. A.; Alexander-Katz, A.; Ross, C. A. Nano Lett. 2018, 18, 4360-4369. “Janus graft block copolymers: design of polymer architecture for independently tuned nanostructures and polymer properties.”Guo, Z.; Le, A. N.; Feng, X.; Choo, Y.; Liu, B.; Wang, D.; Wan, Z.; Gu, Y.; Zhao, J.; Li, V.; Osuji, C.; Johnson, J. A.*; Zhong, M.* Angew. Chem. Int. Ed. 2018, 57, 8493-8497. “Sub-10 nm self-assembly of mesogen-containing grafted macromonomers and their bottlebrush polymers.”Rokhlenko, Y.†; Kawamoto, K.†; Johnson, J. A.*; Osuji, C. O.* Macromolecules 2018, 51, 3680-3690. “Main-chain-zwitterionic supramolecular polymers derived from N–heterocyclic carbene carbodiimide (NHC–CDI) adducts”Gallagher, N. M.; Zhukhovitskiy, A. V.; Nguyen, H. V.-T.; Johnson, J. A.* Macromolecules 2018, 51, 3006-3016. “Scalable synthesis of multivalent macromonomers for ROMP”Nguyen, H. V.-T.; Gallagher, N. M.; Vohidov, F.; Jiang, Y.; Kawamoto, K.; Zhang, H.; Park, J. V.; Huang, Z.; Ottaviani, M. F.; Rajca, A.; Johnson, J. A.* ACS Macro Lett. 2018, 7, 472-476. “Fluorinated Aryl Sulfonimide Tagged (FAST) salts: modular synthesis and structure-property relationships for battery applications”Huang, M.; Feng, S.; Zhang, W.; Giordano, L.; Chen, M.; Amanchukwu, C.; Anandakathir, R.; Shao-Horn, Y.*; Johnson, J. A.* Energy Environ. Sci. 2018, 11, 1326-1334. “Counting secondary loops is required for accurate prediction of end-linked network elasticity”Wang, J.; Lin, T.-S.; Gu, Y.; Wang, R.; Olsen, B. D.*; Johnson, J. A.* ACS Macro Lett. 2018, 7, 244-249. “Stereochemical sequence dictates unimolecular diblock copolymer assembly”Golder, M. R.†; Jiang, Y.†; Teichen, P. E.; Nguyen, H. V.-T.; Wang, W.; Milos, N.; Freedman, S. A.; Willard, A. P.; Johnson, J. A.* J. Am. Chem. Soc. 2018, 140, 1596-1599. “Topological structure of networks formed from symmetric four-arm precursors”Lin, T.-S.; Wang, R.; Johnson, J. A.; Olsen, B. D.* Macromolecules 2018, 51, 1224-1231. “Kinetic Monte Carlo simulation for quantification of the gel point of polymer networks”Wang, R.; Lin, T.-S.; Johnson, J. A.; Olsen, B. D.* ACS Macro Lett. 2017, 6, 1414-1419. “Mapping a stable solvent structure landscape for aprotic Li–air battery organic electrolytes”Feng, S.†; Chen, M.†; Giordano, M.; Huang, M.; Zhang, W.; Amanchukwu, C. V.; Anandakathir, R.; Shao-Horn, Y.*; Johnson, J. A.* J. Mater. Chem. A 2017, 5, 23987-23998. “Mikto-brush-arm star polymers via cross-linking of dissimilar bottlebrushes: synthesis and solution morphologies”Shibuya, Y.; Nguyen, H. V.-T.; Johnson, J. A.* ACS Macro Lett. 2017, 6, 963-968. “Block co-polyMOFs: assembly of polymer-polyMOF hybrids via iterative exponential growth and 'click' chemistry”MacLeod, M. J.; Johnson, J. A.* Polym. Chem. 2017, 8, 4488-4493. “Nitroxide-based macromolecular contrast agents with unprecedented transverse relaxivity and stability for magnetic resonance imaging of tumors”Nguyen, H. V.-T.; Chen, Q.; Paletta, J. T.; Harvey, P.; Jiang, Y.; Zhang, H.; Boska, M. D.; Ottaviani, M. F.; Jasanoff, A.; Rajca, A.; Johnson, J. A.* ACS Cent. Sci. 2017, 3, 800-811.