郑晓峰 - 北京大学 - 生命科学学院

个人简介

教育经历: 1994 - 1998 , 理学博士 , 生化与分子生物学 , 东京农工大学工作经历: 2008年6月 - 至今 , 教授 , 北京大学生命科学学院 2002年5月 - 2008年5月 , 副教授 , 北京大学生命科学学院 1998年4月 - 2002年4月, 博士后研究员 , 美国宾夕法尼亚州大学社会服务工作: 2014年-至今，任生命科学学院学位委员会委员、研究生教育委员会委员。 2012年-至今，任2012级研究生2班班主任工作。荣誉奖励: Bayer学者奖，2020 北京大学优秀博士学位论文指导教师，2020 北京大学优秀教学奖，2017 北京大学优秀班主任，2016 北京大学优秀博士学位论文指导教师，2016 北京大学优秀博士学位论文指导教师，2014 北京大学东宝教师奖 , 2013 北京大学东宝教师奖 , 2009 北京大学青年教师教学基本功优秀奖 , 2007 北京大学东宝教师奖 , 2006 北京市优秀辅导员 , 2006 谈家桢基金生命科学九源导师奖 , 2006 北京大学优秀班主任 , 2005 学术任职: 2021年- 中国生物化学与分子生物学会蛋白质专业委员会委员 2018年- 中国生物化学与分子生物学会理事 2016年- 北京生物化学与分子生物学会副理事长 2015年-至今中国生物物理学会女科学家分会理事 2015年-至今中国生物化学与分子生物学会酶学专业委员会委员、常务委员 2005年-至今中国细胞生物学会会员 2003年-至今中国生物物理学会会员 2003年-至今中国生物化学与分子生物学会会员 1998年-至今美国生物化学学会会员

研究领域

1. 肿瘤发生发展和转移调控蛋白的筛选、鉴定和分子机制研究 2. DNA损伤修复—基因组稳定性----癌症 3. 病毒--固有免疫—DNA损伤应答—炎症和肿瘤

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Huang XP, Zhao Y, Wei M, Zhuge RP, Zheng XF*. (2023) hCINAP alleviates senescence through regulating MDM2 status via multiple mechanisms. Journal of Molecular Cell Biology.Doi: 10.1093/jmcb/mjad015. 2. Zhuge RP, Wang C, Wang J, Yu SY, Liao LM, Zheng XF*. (2023) hCINAP controls lineage differentiation of embryonic stem cells by regulating NEDD4 liquid-liquid phase separation-mediated YAP1 activation. Cell Reports..42(1) 111935. (Jan 31 2023, https://doi.org/10.1016/j.celrep.2022.111935) 3. Huang XP, Yang YF, Zhu D, Zhao Y, Wei M, Li K, Zu HH. Zheng XF*. (2022) PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As2O3 by stabilizing oncoprotein PML-RARα. Cellular and Molecular Life Sciences. 79:319 4. Zhao Y, Huang XP, Zhu D, Wei M, Yu SY, Tian YL, Zheng XF*. (2022) Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy. Cell Death & Differentiation. 29: 2531–2544. Doi: 10.1038/s41418-022-01036-6. 5. Yu SY, Zang WC, Oiu YC, Liao LM, Zheng XF*. (2022) Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis. Oncogene. 41(1):46-56. DOI:10.1038/s41388-021-02071-2. 6. Xu RD, Yang YF, Zheng XF*. (2021) Unique structural features of the adenylate kinase hCINAP/AK6 and its multifaceted functions in carcinogenesis and tumor progression. FEBS Lett. 595(16): 2071-2084. DOI: 10.1002/1873-3468.14158 7. Zhu D, Xu R, Huang X, Tang Z, Tian Y, Zhang J, Zheng XF*. (2021) Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1. Cell Death & Differentiation. 28:1773–1789. Doi: 10.1038/s41418-020-00700-z. 8. Chen SW, Wang YB, Liao LM, Meng L, Li JJ, Shi C, Han H, Zheng XF*, Shen H*. (2020) Similar repair effects of human placenta, bone marrow mesenchymal stem cells and their exosomes for damaged SVOG ovarian granulosa cells. Stem Cell International. Dec 3; 2020: 2020(13):1-17. doi: 10.1155/2020/8861557. 9. Yang YF, Yang CZ, Li TT, Yu SY, Cui J, Zheng XF*. (2020) The deubiquitinase USP38 promotes NHEJ repair through regulation of HDAC1 activity and regulates cancer cell response to genotoxic insults. Cancer Res. 80 (4): 719-731. Dec 24 (online). Doi:10.1158/0008-5472.CAN-19-2149. 10. Zang WC & Zheng XF*. (2020) Structure and Functions of cellular redox sensor HSCARG/NMRAL1, a linkage among redox status, innate immunity, DNA damage response, and cancer. Free Radical Biology and Medicine. 160: 768-774. 11. Zang WC, Yang CZ. Li TT, Liao LM, Zheng XF*. (2019) Cellular redox sensor HSCARG negatively regulates the translesion synthesis pathway and exacerbates mammary tumorigenesis. Proc.Natl.Acad.Sci.USA. December 17, 116 (51): 25624-25633. https://doi.org/10.1073/pnas.1910250116 12. Xu RD, Yu SY, Zhu D, Huang XP, Lao YM, Zhang JF, Tang ZF, Zhang ZM, Yi J, Zhu HH, Zhu, Zheng XF*. (2019) hCINAP regulates the DNA damage response and mediates the resistance of acute myelocytic leukemia cells to therapy. Nature Communications.10，3812. Doi.org/10.1038/s41467-019-11795-5. 13. Yang CZ, Zang WC, Ji YP, Li TT, Yang YF, Zheng XF*. (2019) Ribosomal protein L6 (RPL6) is recruited to DNA damage sites in a poly(ADP-ribose) polymerase-dependent manner and regulates the DNA damage response. J Biol Chem. 294(8): 2827-2838. Doi: 10.1074/jbc.RA118.007009 14. Guan JH, Zheng XF*. (2019) NEDDylation regulates RAD18 ubiquitination and localization in response to oxidative DNA damage. Biochemical Biophysical Research Communications. 508: 1240-1244. Doi.org/10.1016/j.bbrc.2018.12.072. 15. Amanda Constantinides, Chelsea Severin, Ryan Gumpper, Xiaofeng Zheng*, Ming Luo*. (2018) Characterizations of the PB2 Cap Binding Domain Accelerate Inhibitor Design. Crystals. 8 (2). Doi:10.3390/cryst8020062. 16. Yang CZ, Zang WC, Tang ZF, Ji YP, Xu RD, Yang YF, Luo AP, Hu B, Zhang ZM, Liu ZH, Zheng XF*. (2018) A20 regulates the DNA damage response and mediates tumor cell resistance to DNA damaging therapy. Cancer Research. 78(4): 1069-1082. Doi: 10.1158/0008-5472.CAN-17-2143. 17. Zhang L, Liu J, Qian L, Feng Q, Wang X, Yuan Y, Zuo Y, Cheng Q, Miao Y, Guo T, Zheng XF, Zheng H*. (2018) Induction of OTUD1 by RNA Viruses Potently Inhibits Innate Immune Responses by Promoting Degradation of the MAVS/TRAF3/TRAF6 Signalosome. PLoS Pathogens. 14(5): e1007067. DOI: 10.1371/journal.ppat.1007067. 18. Guan JH, Yu SY, Zheng XF*. (2018) NEDDylation antagonizes ubiquitination of proliferating cell nuclear antigen and regulates the recruitment of polymerase η in response to oxidative DNA damage. Protein Cell. 9(4):365-379. DOI 10.1007/s13238-017-0455-x. 19. Ji YP, Yang CZ, Tang ZF, Yang YF, Tian YL, Yao HW, Zhu X, Zhang ZM, Ji JF, Zheng XF*. (2017) Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells in a glycolysis-dependent manner by facilitating LDHA phosphorylation. Nature Communications. 8:15308. Doi.10.1038/ncomms15308. 20. Dong XD, Guan JH, Zheng CF, Zheng XF*. (2017, May 19) The herpes simplex virus 1 UL36USP deubiquitinase suppresses DNA repair in host cells via deubiquitination of proliferating cell nuclear antigen. J Biol Chem. 292 (20): 8472-8483. DOI 10.1074/jbc.M117.778076. 21. Bai DM, Zheng XF*. (2017) PML-RARA mutations confer varying arsenic trioxide resistance. Protein & Cell. 8(4):296–301. DOI: 10.1007/s13238-016-0356-4. 22. Yan FX, Guan JH, Peng YY, Zheng XF*. (2017) MyD88 NEDDylation negatively regulates MyD88-dependent NF-κB signaling through antagonizing its ubiquitination. Biochemical and Biophysical Research Communications. 482 (4): 632-637. 23. Bai DM, Zhang J, Li T, Hang R, Liu Y, Tian Y, Huang D, Qu L, Cao XF, Ji J-F, Zheng XF*. (2016) The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumor growth. Nature Communications.7: 12310. 24. Severin C,, Rocha de Moura T, Liu Y, Li K, Zheng XF*, Luo M*. (2016) The cap binding site of influenza virus protein PB2 as a drug target. Acta Cryst. D72, 245-253. 25. Qu LL, Ji YP, Zhu X, Zheng XF*. (2015) hCINAP Negatively Regulates NF-κB Signaling by Recruiting the Phosphatase PP1 to Deactivate IKK Complex. Journal of Molecular Cell Biology. 7 (6): 529-542. doi: 10.1093/jmcb/mjv041. 26. Liu Y, Yang YF, Fan JL, He RN, Luo M, Zheng XF*. (2015) The Crystal Structure of PB2 Cap-binding Domain of Influenza B Virus Reveals a Novel Cap Recognition Mechanism. J Biol. Chem. 290(14): 9141-9149. 27. Li TT, Guan J, Li SZ, Zhang XD, Zheng XF*. (2014) HSCARG downregulates TNF-induced NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination. Cell Difference & Diseases.5: e1229. Doi: 10.1038/cddis.2014.197. 28. Hu B, Li SZ, Zhang XD, Zheng XF*. (2014) HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation. Nucleic Acid Res. 42, 5582-5593 29. Li G, Qu L, Ma S, Wu Y, J CW, Zheng XF*. (2014) Structures determination of human Fas Apoptosis Inhibitory Molecule and identification of the critical residues linking the interdomain interaction to the anti-apoptotic activity. Acta crystallographica section D. D70, 1812-1822. 30. Peng YY, Xu RD, Zheng XF*. (2014) HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1. PLoS Pathogens. 10(4): e1004041. 31. Li TT, Guan JH, Huang ZJ, Hu X, Zheng XF*. (2014) RNF168-mediated H2A neddylation antagonizes its ubiquitination and regulates DNA damage repair. J Cell Sci. 127: 2238-2248. 32. Zhang JF, Bai DM, Ma XW, Guan JH, Zheng XF*. (2014) hCINAP is a novel regulator of ribosomal protein-HDM2-p53 pathway by controlling NEDDylation of ribosomal protein S14. Oncogene. 33, 246-254. doi: 10.1038/onc.2012.560. 33. Xiao W, Meng G, Zhao Y, Yuan H, Li T, Peng Y, Zhao Y, Luo M, Zhao, WM, Li Z, Zheng XF*. (2014) Human secreted stabilin-1-interacting chitinase-like protein aggravates the inflammation associated with rheumatoid arthritis and is a potential macrophage inflammatory regulator in rodents. ARTHRITIS & RHEUMATOLOGY. 66(5):1141-1152. 34. Bai DM, Zhang J, Xiao WC, Zheng XF*. (2014) Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress. Nucleic Acid Res. 42(3):1799-1811. 35. Meng G, An X, Ye, S, Liu Y, Zhu W, Zhang R, Zheng XF*. (2013) The crystal structure of LidA, a translocated substrate of the Legionella pneumophila Type IV secretion system, reveals a novel folding. Protein & Cell. 4(12):897-900. 36. Bai XY, Zheng XF*. (2013) Tip-to-tip interaction in the crystal packing of PACSIN 2 is important in regulating tubulation activity. Protein & Cell. 4(3): 211–219. 37. Xiao WC, Peng YY, Liu Y, Li Z, Li SL, Zheng XF*. (2013) HSCARG inhibits NADPH oxidase activity through regulation of the expression of p47phox. PLoS One. 8(3): e59301. 38. Liu Y, Qin K, Meng G, Zhang J, Zhou JF, Zhao GY, Luo M, Zheng XF*. (2013) Structural and Functional Characterization of K339T Substitution Identified in the PB2 subunit Cap-binding Pocket of Influenza A Virus. J Biol. Chem. 288(16): 11013-11023. 39. Liu Y, Meng G, Luo M, Zheng XF*. (2013) Crystallization and X-ray crystallographic analysis on the cap binding domain of influenza A virus H1N1 polymerase subunit PB2. Acta crystallgrophy F. 69: 280-283. 40. Feng X, Yang R, Zheng XF*, Zhang F. (2012) Identification of a novel nuclear-localized adenylate kinase 6 from Arabidopsis thaliana as an essential stem growth factor. Plant Physiol Biochem. 61: 180-186. 41. Bai X, Meng G, Luo,M, Zheng XF*. (2012) Rigidity of the Wedge Loop in PACSIN 3 is a Key Factor in Dictating the Diameters of Tubules. J Biol. Chem. 287(26):22387-22396. 42. Zhang M, Hu B, Li T, Peng Y, Guan J, Lai S, Li Z, Zheng XF*. (2012) A CRM1-dependent nuclear export signal controls nucleocytoplasmic translocation of HSCARG, which regulates NF-κB activity. Traffic. 13(6):790-799. 43. Yu Q, Zheng XF*. (2012) The crystal structure of human UDP-glucose pyrophosphorylase reveals a latch effect important for regulating pyrophosphorylase activity. Biochemical J. 442(2): 283-291. 44. Bai X, Meng G, Zheng XF*. (2012) Cloning, purification, crystallization and preliminary X-ray diffraction analysis of mouse PACSIN 3 protein from Escherichia coli. Acta crystallgrophy F68, 159-162.